HPSE | ENSG00000173083 | NCBI 10855

Details for: HPSE

Gene ID: 10855

Symbol: HPSE

Ensembl ID: ENSG00000173083

Description: heparanase

Associated with

Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag degradation
(R-HSA-2024096)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Neutrophil degranulation
(R-HSA-6798695)
Angiogenesis involved in wound healing
(GO:0060055)
Beta-glucuronidase activity
(GO:0004566)
Cell-matrix adhesion
(GO:0007160)
Establishment of endothelial barrier
(GO:0061028)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heparanase activity
(GO:0030305)
Heparan sulfate proteoglycan catabolic process
(GO:0030200)
Heparin metabolic process
(GO:0030202)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal lumen
(GO:0043202)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane raft
(GO:0045121)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of hair follicle development
(GO:0051798)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein binding
(GO:0005515)
Protein transmembrane transport
(GO:0071806)
Proteoglycan metabolic process
(GO:0006029)
Regulation of hair follicle development
(GO:0051797)
Response to organic substance
(GO:0010033)
Specific granule lumen
(GO:0035580)
Syndecan binding
(GO:0045545)
Vascular wound healing
(GO:0061042)

Other Information

Proteins

Heparanase

Genular Protein ID: 1167821912

Symbol: HPSE_HUMAN

Name: Heparanase

UniProtKB Accession Codes:

Q9Y251 A9JIG7 C7F7I3 C7F7I4 E9PCA9 E9PGR1 Q53GE5 Q9UL39

Database IDs:

Citations:

PubMed ID: 10405343

Title: Cloning and functional expression of a human heparanase gene.

PubMed ID: 10405343

DOI: 10.1006/bbrc.1999.0962

PubMed ID: 10446189

Title: Human heparanase. Purification, characterization, cloning, and expression.

PubMed ID: 10446189

DOI: 10.1074/jbc.274.34.24153

PubMed ID: 10395325

Title: Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.

PubMed ID: 10395325

DOI: 10.1038/10518

PubMed ID: 10395326

Title: Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.

PubMed ID: 10395326

DOI: 10.1038/10525

PubMed ID: 10764835

Title: Heparanase expression in invasive trophoblasts and acute vascular damage.

PubMed ID: 10764835

DOI: 10.1093/glycob/10.5.467

PubMed ID: 11547900

Title: Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.

PubMed ID: 11547900

DOI: 10.1023/a:1011375624902

PubMed ID: 12713442

Title: Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.

PubMed ID: 12713442

DOI: 10.1042/bj20030318

PubMed ID: 17208203

Title: Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.

PubMed ID: 17208203

DOI: 10.1016/j.bbrc.2006.12.189

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11123890

Title: Identification of active-site residues of the pro-metastatic endoglycosidase heparanase.

PubMed ID: 11123890

DOI: 10.1021/bi002080p

PubMed ID: 12441129

Title: Human heparanase is localized within lysosomes in a stable form.

PubMed ID: 12441129

DOI: 10.1006/excr.2002.5651

PubMed ID: 12213822

Title: Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence.

PubMed ID: 12213822

DOI: 10.1074/jbc.m206510200

PubMed ID: 11973358

Title: Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts.

PubMed ID: 11973358

DOI: 10.1242/jcs.115.10.2179

PubMed ID: 12927802

Title: Heterodimer formation is essential for heparanase enzymatic activity.

PubMed ID: 12927802

DOI: 10.1016/s0006-291x(03)01478-5

PubMed ID: 12773484

Title: Heparanase mediates cell adhesion independent of its enzymatic activity.

PubMed ID: 12773484

DOI: 10.1096/fj.02-0773com

PubMed ID: 14573609

Title: Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.

PubMed ID: 14573609

DOI: 10.1074/jbc.m300541200

PubMed ID: 15044433

Title: Heparanase induces endothelial cell migration via protein kinase B/Akt activation.

PubMed ID: 15044433

DOI: 10.1074/jbc.m400554200

PubMed ID: 15292202

Title: Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.

PubMed ID: 15292202

DOI: 10.1074/jbc.m402131200

PubMed ID: 15126626

Title: Processing and activation of latent heparanase occurs in lysosomes.

PubMed ID: 15126626

DOI: 10.1242/jcs.01068

PubMed ID: 15848168

Title: Heparanase processing by lysosomal/endosomal protein preparation.

PubMed ID: 15848168

DOI: 10.1016/j.febslet.2005.03.030

PubMed ID: 15659389

Title: Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase.

PubMed ID: 15659389

DOI: 10.1074/jbc.m413370200

PubMed ID: 15760902

Title: Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.

PubMed ID: 15760902

DOI: 10.1074/jbc.m414546200

PubMed ID: 16452201

Title: Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.

PubMed ID: 16452201

DOI: 10.1158/0008-5472.can-05-1811

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18557927

Title: Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis.

PubMed ID: 18557927

DOI: 10.1111/j.1600-0625.2008.00739.x

PubMed ID: 18798279

Title: Heparanase induces VEGF C and facilitates tumor lymphangiogenesis.

PubMed ID: 18798279

DOI: 10.1002/ijc.23898

PubMed ID: 19244131

Title: Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.

PubMed ID: 19244131

DOI: 10.1158/0008-5472.can-08-1837

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20097882

Title: Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

PubMed ID: 20097882

DOI: 10.1182/blood-2009-07-234757

PubMed ID: 20634491

Title: Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.

PubMed ID: 20634491

DOI: 10.3324/haematol.2010.023713

PubMed ID: 20561914

Title: Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions.

PubMed ID: 20561914

DOI: 10.1016/j.biocel.2010.05.008

PubMed ID: 20181948

Title: Unraveling the specificity of heparanase utilizing synthetic substrates.

PubMed ID: 20181948

DOI: 10.1074/jbc.m110.104166

PubMed ID: 20576607

Title: Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.

PubMed ID: 20576607

DOI: 10.1074/jbc.m110.116384

PubMed ID: 20309870

Title: Heparanase in primary human osteoblasts.

PubMed ID: 20309870

DOI: 10.1002/jor.21138

PubMed ID: 21131364

Title: Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.

PubMed ID: 21131364

DOI: 10.1074/jbc.m110.183277

PubMed ID: 26575439

Title: Structural characterization of human heparanase reveals insights into substrate recognition.

PubMed ID: 26575439

DOI: 10.1038/nsmb.3136

PubMed ID: 26733221

Title: Corrigendum: Structural characterization of human heparanase reveals insights into substrate recognition.

PubMed ID: 26733221

DOI: 10.1038/nsmb0116-91

PubMed ID: 28581485

Title: Activity-based probes for functional interrogation of retaining beta-glucuronidases.

PubMed ID: 28581485

DOI: 10.1038/nchembio.2395

PubMed ID: 15334672

Title: Heparanase mRNA expression and point mutation in hepatocellular carcinoma.

PubMed ID: 15334672

DOI: 10.3748/wjg.v10.i19.2795

Sequence Information:

Length: 543
Mass: 61149
Checksum: A990F5AFD639CA1A
Sequence:

MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT 
IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS 
QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS 
GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS 
QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL 
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA 
AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM 
ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL 
RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA 
ACI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HPSE

Associated with

Other Information

Cloning and functional expression of a human heparanase gene. PubMed ID: 10405343

Human heparanase. Purification, characterization, cloning, and expression. PubMed ID: 10446189

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. PubMed ID: 10395325

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. PubMed ID: 10395326

Heparanase expression in invasive trophoblasts and acute vascular damage. PubMed ID: 10764835

Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis. PubMed ID: 11547900

Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. PubMed ID: 12713442

Cloning, expression, and characterization of an alternatively spliced variant of human heparanase. PubMed ID: 17208203

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. PubMed ID: 11123890

Human heparanase is localized within lysosomes in a stable form. PubMed ID: 12441129

Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence. PubMed ID: 12213822

Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. PubMed ID: 11973358

Heterodimer formation is essential for heparanase enzymatic activity. PubMed ID: 12927802

Heparanase mediates cell adhesion independent of its enzymatic activity. PubMed ID: 12773484

Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines. PubMed ID: 14573609

Heparanase induces endothelial cell migration via protein kinase B/Akt activation. PubMed ID: 15044433

Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. PubMed ID: 15292202

Processing and activation of latent heparanase occurs in lysosomes. PubMed ID: 15126626

Heparanase processing by lysosomal/endosomal protein preparation. PubMed ID: 15848168

Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. PubMed ID: 15659389

Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. PubMed ID: 15760902

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. PubMed ID: 16452201

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis. PubMed ID: 18557927

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. PubMed ID: 18798279

Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. PubMed ID: 19244131

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. PubMed ID: 20097882

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII. PubMed ID: 20634491

Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions. PubMed ID: 20561914

Unraveling the specificity of heparanase utilizing synthetic substrates. PubMed ID: 20181948

Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. PubMed ID: 20576607

Heparanase in primary human osteoblasts. PubMed ID: 20309870

Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity. PubMed ID: 21131364

Structural characterization of human heparanase reveals insights into substrate recognition. PubMed ID: 26575439

Corrigendum: Structural characterization of human heparanase reveals insights into substrate recognition. PubMed ID: 26733221

Activity-based probes for functional interrogation of retaining beta-glucuronidases. PubMed ID: 28581485

Heparanase mRNA expression and point mutation in hepatocellular carcinoma. PubMed ID: 15334672