Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.22
Marker Score: 2,475 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,787 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,805 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,030 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.99
Marker Score: 55,298 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 496 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,734 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5,184 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 362 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,279 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.86
Marker Score: 585 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.82
Marker Score: 1,553 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,249 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3,155 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.75
Marker Score: 1,545 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 385 - Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 667 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.7
Marker Score: 535 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.69
Marker Score: 288 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.67
Marker Score: 1,646 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.66
Marker Score: 10,255 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.64
Marker Score: 437 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.63
Marker Score: 631 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6
Marker Score: 636 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.58
Marker Score: 186 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.54
Marker Score: 265 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.51
Marker Score: 308 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.51
Marker Score: 325 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.49
Marker Score: 4,183 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.47
Marker Score: 919 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.47
Marker Score: 847 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.46
Marker Score: 382 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.45
Marker Score: 223 - Cell Name: blood cell (CL0000081)
Fold Change: 0.44
Marker Score: 5,112 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.43
Marker Score: 2,623 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.43
Marker Score: 416 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.41
Marker Score: 274 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.4
Marker Score: 166 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.37
Marker Score: 151 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.37
Marker Score: 586 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.36
Marker Score: 416 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.36
Marker Score: 239 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.35
Marker Score: 112 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.35
Marker Score: 383 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.34
Marker Score: 12,820 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.33
Marker Score: 1,362 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.33
Marker Score: 320 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.32
Marker Score: 116 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.32
Marker Score: 91 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.3
Marker Score: 80 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.3
Marker Score: 543 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.3
Marker Score: 202 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.29
Marker Score: 140 - Cell Name: platelet (CL0000233)
Fold Change: 0.29
Marker Score: 132 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.29
Marker Score: 720 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.29
Marker Score: 650 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.28
Marker Score: 685 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.28
Marker Score: 159 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.28
Marker Score: 96 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.28
Marker Score: 169 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.28
Marker Score: 2,163 - Cell Name: monocyte (CL0000576)
Fold Change: 0.28
Marker Score: 358 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.27
Marker Score: 150 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.26
Marker Score: 83 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.26
Marker Score: 232 - Cell Name: macrophage (CL0000235)
Fold Change: 0.26
Marker Score: 286 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.25
Marker Score: 122 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.24
Marker Score: 152 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.24
Marker Score: 139 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.24
Marker Score: 165 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.24
Marker Score: 143 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.23
Marker Score: 321 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.23
Marker Score: 8,347 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: Unknown (CL0000548)
Fold Change: 0.22
Marker Score: 163 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.21
Marker Score: 1,361 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.21
Marker Score: 651 - Cell Name: basal cell (CL0000646)
Fold Change: 0.21
Marker Score: 267 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.21
Marker Score: 113 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2
Marker Score: 69 - Cell Name: club cell (CL0000158)
Fold Change: 0.2
Marker Score: 237 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.2
Marker Score: 46 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.2
Marker Score: 69 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.2
Marker Score: 46 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.2
Marker Score: 93 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.2
Marker Score: 57 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2
Marker Score: 81 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.19
Marker Score: 196 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.19
Marker Score: 45 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.19
Marker Score: 46 - Cell Name: germ cell (CL0000586)
Fold Change: 0.19
Marker Score: 334 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.19
Marker Score: 42 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.19
Marker Score: 523 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.19
Marker Score: 41
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1167821912
Symbol: HPSE_HUMAN
Name: Heparanase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10405343
Title: Cloning and functional expression of a human heparanase gene.
PubMed ID: 10405343
PubMed ID: 10446189
Title: Human heparanase. Purification, characterization, cloning, and expression.
PubMed ID: 10446189
PubMed ID: 10395325
Title: Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
PubMed ID: 10395325
DOI: 10.1038/10518
PubMed ID: 10395326
Title: Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.
PubMed ID: 10395326
DOI: 10.1038/10525
PubMed ID: 10764835
Title: Heparanase expression in invasive trophoblasts and acute vascular damage.
PubMed ID: 10764835
PubMed ID: 11547900
Title: Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
PubMed ID: 11547900
PubMed ID: 12713442
Title: Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.
PubMed ID: 12713442
DOI: 10.1042/bj20030318
PubMed ID: 17208203
Title: Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.
PubMed ID: 17208203
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11123890
Title: Identification of active-site residues of the pro-metastatic endoglycosidase heparanase.
PubMed ID: 11123890
DOI: 10.1021/bi002080p
PubMed ID: 12441129
Title: Human heparanase is localized within lysosomes in a stable form.
PubMed ID: 12441129
PubMed ID: 12213822
Title: Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence.
PubMed ID: 12213822
PubMed ID: 11973358
Title: Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts.
PubMed ID: 11973358
PubMed ID: 12927802
Title: Heterodimer formation is essential for heparanase enzymatic activity.
PubMed ID: 12927802
PubMed ID: 12773484
Title: Heparanase mediates cell adhesion independent of its enzymatic activity.
PubMed ID: 12773484
PubMed ID: 14573609
Title: Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.
PubMed ID: 14573609
PubMed ID: 15044433
Title: Heparanase induces endothelial cell migration via protein kinase B/Akt activation.
PubMed ID: 15044433
PubMed ID: 15292202
Title: Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.
PubMed ID: 15292202
PubMed ID: 15126626
Title: Processing and activation of latent heparanase occurs in lysosomes.
PubMed ID: 15126626
DOI: 10.1242/jcs.01068
PubMed ID: 15848168
Title: Heparanase processing by lysosomal/endosomal protein preparation.
PubMed ID: 15848168
PubMed ID: 15659389
Title: Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase.
PubMed ID: 15659389
PubMed ID: 15760902
Title: Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
PubMed ID: 15760902
PubMed ID: 16452201
Title: Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
PubMed ID: 16452201
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 18557927
Title: Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis.
PubMed ID: 18557927
PubMed ID: 18798279
Title: Heparanase induces VEGF C and facilitates tumor lymphangiogenesis.
PubMed ID: 18798279
DOI: 10.1002/ijc.23898
PubMed ID: 19244131
Title: Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.
PubMed ID: 19244131
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20097882
Title: Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.
PubMed ID: 20097882
PubMed ID: 20634491
Title: Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.
PubMed ID: 20634491
PubMed ID: 20561914
Title: Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions.
PubMed ID: 20561914
PubMed ID: 20181948
Title: Unraveling the specificity of heparanase utilizing synthetic substrates.
PubMed ID: 20181948
PubMed ID: 20576607
Title: Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
PubMed ID: 20576607
PubMed ID: 20309870
PubMed ID: 21131364
Title: Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.
PubMed ID: 21131364
PubMed ID: 26575439
Title: Structural characterization of human heparanase reveals insights into substrate recognition.
PubMed ID: 26575439
DOI: 10.1038/nsmb.3136
PubMed ID: 26733221
Title: Corrigendum: Structural characterization of human heparanase reveals insights into substrate recognition.
PubMed ID: 26733221
DOI: 10.1038/nsmb0116-91
PubMed ID: 28581485
Title: Activity-based probes for functional interrogation of retaining beta-glucuronidases.
PubMed ID: 28581485
PubMed ID: 15334672
Title: Heparanase mRNA expression and point mutation in hepatocellular carcinoma.
PubMed ID: 15334672
Sequence Information:
- Length: 543
- Mass: 61149
- Checksum: A990F5AFD639CA1A
- Sequence:
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA ACI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.