Details for: RUVBL2

Gene ID: 10856

Symbol: RUVBL2

Ensembl ID: ENSG00000183207

Description: RuvB like AAA ATPase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.93
    Marker Score: 3,052
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.69
    Marker Score: 23,373
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.89
    Marker Score: 3,587
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.79
    Marker Score: 6,150
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.78
    Marker Score: 7,272
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.73
    Marker Score: 3,606
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.7
    Marker Score: 1,152
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.66
    Marker Score: 6,532
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.52
    Marker Score: 1,015
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.49
    Marker Score: 2,138
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.48
    Marker Score: 4,026
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.47
    Marker Score: 1,480
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.46
    Marker Score: 1,546
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,425
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.46
    Marker Score: 2,474
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.45
    Marker Score: 3,954
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.45
    Marker Score: 689
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.41
    Marker Score: 1,059
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.41
    Marker Score: 1,328
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.39
    Marker Score: 48,243
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.37
    Marker Score: 440
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.36
    Marker Score: 11,735
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.36
    Marker Score: 1,463
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.35
    Marker Score: 1,439
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.35
    Marker Score: 3,211
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5,676
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.32
    Marker Score: 2,777
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.32
    Marker Score: 826
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.3
    Marker Score: 1,627
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.29
    Marker Score: 934
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.27
    Marker Score: 1,352
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.25
    Marker Score: 687
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12,388
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.2
    Marker Score: 1,596
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2
    Marker Score: 7,803
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.2
    Marker Score: 1,698
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.15
    Marker Score: 729
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.14
    Marker Score: 400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.13
    Marker Score: 3,342
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.12
    Marker Score: 11,257
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.11
    Marker Score: 14,691
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.1
    Marker Score: 1,805
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.1
    Marker Score: 258
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.1
    Marker Score: 1,230
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.08
    Marker Score: 535
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.08
    Marker Score: 615
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2,510
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.05
    Marker Score: 478
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16,224
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.03
    Marker Score: 8,042
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.03
    Marker Score: 346
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7,547
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.01
    Marker Score: 291
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.01
    Marker Score: 1,786
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2,285
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 284
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1
    Marker Score: 473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,665
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,890
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.99
    Marker Score: 11,146
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 825
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.98
    Marker Score: 713
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.97
    Marker Score: 918
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.97
    Marker Score: 3,750
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.97
    Marker Score: 484
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.95
    Marker Score: 236
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.94
    Marker Score: 3,491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,387
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.92
    Marker Score: 2,248
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.92
    Marker Score: 295
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1,406
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.91
    Marker Score: 541
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,192
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.9
    Marker Score: 269
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.89
    Marker Score: 228
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.89
    Marker Score: 1,313
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.89
    Marker Score: 10,331
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.89
    Marker Score: 814
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.88
    Marker Score: 304
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.88
    Marker Score: 462
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.87
    Marker Score: 1,640
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.86
    Marker Score: 543
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.86
    Marker Score: 900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.85
    Marker Score: 211
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.85
    Marker Score: 1,000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.85
    Marker Score: 454
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.85
    Marker Score: 602
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.85
    Marker Score: 318
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.84
    Marker Score: 5,400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.84
    Marker Score: 4,964
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1,328
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.83
    Marker Score: 459
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.83
    Marker Score: 970
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.82
    Marker Score: 733

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RUVBL2 is a member of the RuvB-like ATPase family, which is known for its involvement in DNA replication, recombination, and repair. The gene encodes a protein that exhibits high sequence similarity to the RuvB protein, a key component of the Ruv recombinase complex. This complex plays a crucial role in resolving Holliday junctions and ensuring the accurate repair of DNA breaks. RUVBL2 is also involved in chromatin remodeling, telomere maintenance, and transcriptional regulation. **Pathways and Functions:** RUVBL2 is implicated in various cellular pathways, including: 1. **DNA Repair:** RUVBL2 is involved in the repair of DNA double-strand breaks via homologous recombination and non-homologous end joining. It also regulates the activity of DNA repair proteins, such as BRCA1 and BRCA2. 2. **Telomere Maintenance:** RUVBL2 is essential for maintaining telomere length and preventing telomere shortening. It interacts with telomerase and regulates the localization of telomerase RNA to Cajal bodies. 3. **Chromatin Remodeling:** RUVBL2 is involved in chromatin remodeling, which is critical for regulating gene expression and maintaining genome stability. It interacts with chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases. 4. **Transcriptional Regulation:** RUVBL2 regulates transcriptional activity by interacting with RNA polymerase II and modulating the activity of transcription factors, such as β-catenin and TBP. **Clinical Significance:** Dysregulation of RUVBL2 has been linked to various diseases, including: 1. **Cancer:** RUVBL2 is often down-regulated in cancer cells, leading to impaired DNA repair and telomere maintenance. This can contribute to cancer progression and poor prognosis. 2. **Neurodegenerative Disorders:** RUVBL2 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Its dysregulation can lead to impaired DNA repair and chromatin remodeling, contributing to neuronal dysfunction. 3. **Genetic Disorders:** RUVBL2 mutations have been associated with genetic disorders, such as Fanconi anemia and Bloom syndrome. These disorders are characterized by impaired DNA repair and increased risk of cancer. In conclusion, RUVBL2 is a critical gene that plays a pivotal role in maintaining genome stability and regulating chromatin structure. Its dysregulation has been linked to various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which RUVBL2 regulates cellular processes and to develop therapeutic strategies for its dysregulation.

Genular Protein ID: 698244862

Symbol: RUVB2_HUMAN

Name: RuvB-like 2

UniProtKB Accession Codes:

Q9Y230 B3KQ59 E7ETE5 Q6FIB9 Q6PK27 Q9Y361

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 7 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 15 EMDB 17 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 15 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10524211

Title: Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins.

PubMed ID: 10524211

DOI: 10.1016/s0167-4781(99)00104-9

PubMed ID: 10428817

Title: TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.

PubMed ID: 10428817

DOI: 10.1074/jbc.274.32.22437

PubMed ID: 10998447

Title: Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3.

PubMed ID: 10998447

DOI: 10.1016/s0003-3995(00)01016-9

PubMed ID: 11080158

Title: Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.

PubMed ID: 11080158

DOI: 10.1093/emboj/19.22.6121

PubMed ID: 10882073

Title: An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.

PubMed ID: 10882073

DOI: 10.1016/s1097-2765(00)80427-x

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10966108

Title: Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

PubMed ID: 10966108

DOI: 10.1016/s0092-8674(00)00051-9

PubMed ID: 12963728

Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

PubMed ID: 12963728

DOI: 10.1074/jbc.c300389200

PubMed ID: 11713276

Title: TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage.

PubMed ID: 11713276

DOI: 10.1128/mcb.21.24.8398-8413.2001

PubMed ID: 14966270

Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

PubMed ID: 14966270

DOI: 10.1128/mcb.24.5.1884-1896.2004

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 16230350

Title: A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.

PubMed ID: 16230350

DOI: 10.1074/jbc.m509128200

PubMed ID: 16014379

Title: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.

PubMed ID: 16014379

DOI: 10.1242/jcs.02437

PubMed ID: 17157868

Title: Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex.

PubMed ID: 17157868

DOI: 10.1016/j.jmb.2006.11.030

PubMed ID: 18026119

Title: A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

PubMed ID: 18026119

DOI: 10.1038/nsmb1332

PubMed ID: 17967892

Title: Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

PubMed ID: 17967892

DOI: 10.1128/mcb.00607-07

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19299493

Title: Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.

PubMed ID: 19299493

DOI: 10.1093/hmg/ddp134

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20864032

Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

PubMed ID: 20864032

DOI: 10.1016/j.molcel.2010.08.037

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303910

Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

PubMed ID: 21303910

DOI: 10.1074/jbc.m111.222505

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25437307

Title: LINKIN, a new transmembrane protein necessary for cell adhesion.

PubMed ID: 25437307

DOI: 10.7554/elife.04449

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24463511

Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.

PubMed ID: 24463511

DOI: 10.1038/nature12922

PubMed ID: 25652260

Title: Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.

PubMed ID: 25652260

DOI: 10.15252/embr.201439123

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

PubMed ID: 28561026

Title: R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

PubMed ID: 28561026

DOI: 10.1038/ncomms15615

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29601588

Title: ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.

PubMed ID: 29601588

DOI: 10.1371/journal.pgen.1007316

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

PubMed ID: 33367824

Title: NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis.

PubMed ID: 33367824

DOI: 10.1093/nar/gkaa1226

PubMed ID: 33205750

Title: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.

PubMed ID: 33205750

DOI: 10.7554/elife.63042

Sequence Information:

  • Length: 463
  • Mass: 51157
  • Checksum: 54C78E9C587D975A
  • Sequence:
    • MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL 
EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT 
QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE 
SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH 
TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE 
VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT 
PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE 
VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS

Genular Protein ID: 2984629909

Symbol: B3KNL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNL2

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 GO 9 Gene3D 3 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 2 RuleBase 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 429
  • Mass: 47404
  • Checksum: 6280330793DD67CD
  • Sequence:
    • MCASHPQASQ GMVGQLAARR AAGVVLEMIR EGKIAGRAVL IAGQPGTGKT AIAMGMAQAL 
GPDTPFTAIA GSEIFSLEMS KTEALTQAFR RSIGVRIKEE TEIIEGEVVE IQIDRPATGT 
GSKVGKLTLK TTEMETIYDL GTKMIESLTK DKVQAGDVIT IDKATGKISK LGRSFTRARD 
YDAMGSQTKF VQCPDGELQK RKEVVHTVSL HEIDVINSRT QGFLALFSGD TGEIKSEVRE 
QINAKVAEWR EEGKAEIIPG VLFIDEVHML DIESFSFLNR ALESDMAPVL IMATNRGITR 
IRGTSYQSPH GIPIDLLDRL LIVSTTPYSE KDTKQILRIR CEEEDVEMSE DAYTVLTRIG 
LETSLRYAIQ LITAASLVCR KRKGTEVQVD DIKRVYSLFL DESRSTQYMK EYQDAFLFNE 
LKGETMDTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.