CYP46A1 | ENSG00000036530 | NCBI 10858

Details for: CYP46A1

Gene ID: 10858

Symbol: CYP46A1

Ensembl ID: ENSG00000036530

Description: cytochrome P450 family 46 subfamily A member 1

Associated with

Bile acid and bile salt metabolism
(R-HSA-194068)
Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Endogenous sterols
(R-HSA-211976)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Phase i - functionalization of compounds
(R-HSA-211945)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(R-HSA-193775)
Bile acid biosynthetic process
(GO:0006699)
Cholesterol 24-hydroxylase activity
(GO:0033781)
Cholesterol catabolic process
(GO:0006707)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Heme binding
(GO:0020037)
Iron ion binding
(GO:0005506)
Nervous system development
(GO:0007399)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Progesterone metabolic process
(GO:0042448)
Protein localization to membrane raft
(GO:1903044)
Regulation of long-term synaptic potentiation
(GO:1900271)
Steroid hydroxylase activity
(GO:0008395)
Sterol metabolic process
(GO:0016125)
Testosterone 16-beta-hydroxylase activity
(GO:0062184)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cholesterol 24-monooxygenase

Genular Protein ID: 4010251252

Symbol: CP46A_HUMAN

Name: Cholesterol 24-monooxygenase

UniProtKB Accession Codes:

Q9Y6A2 B4DHP8 E7EQG9 Q8N2B0

Database IDs:

Citations:

PubMed ID: 10377398

Title: cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.

PubMed ID: 10377398

DOI: 10.1073/pnas.96.13.7238

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12077124

Title: Metabolism of 4 beta -hydroxycholesterol in humans.

PubMed ID: 12077124

DOI: 10.1074/jbc.m201712200

PubMed ID: 14640697

Title: Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

PubMed ID: 14640697

DOI: 10.1021/bi035512f

PubMed ID: 25017465

Title: Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.

PubMed ID: 25017465

DOI: 10.1194/jlr.m051508

PubMed ID: 28190002

Title: Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.

PubMed ID: 28190002

DOI: 10.1074/jbc.m116.774760

PubMed ID: 18621681

Title: Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.

PubMed ID: 18621681

DOI: 10.1073/pnas.0803717105

PubMed ID: 20667828

Title: Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.

PubMed ID: 20667828

DOI: 10.1074/jbc.m110.143313

PubMed ID: 23288837

Title: Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.

PubMed ID: 23288837

DOI: 10.1074/jbc.m112.438754

Sequence Information:

Length: 500
Mass: 56821
Checksum: AB9307749D9E5FDA
Sequence:

MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPCFW KKDEVGGRVL 
QDVFLDWAKK YGPVVRVNVF HKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL 
FGQGLVSECN YERWHKQRRV IDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM 
QDMLTYTAMD ILAKAAFGME TSMLLGAQKP LSQAVKLMLE GITASRNTLA KFLPGKRKQL 
REVRESIRFL RQVGRDWVQR RREALKRGEE VPADILTQIL KAEEGAQDDE GLLDNFVTFF 
IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVIGSKR YLDFEDLGRL QYLSQVLKES 
LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA 
PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRLEF RLVPGQRFGL QEQATLKPLD 
PVLCTLRPRG WQPAPPPPPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP46A1

Associated with

Other Information

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. PubMed ID: 10377398

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Metabolism of 4 beta -hydroxycholesterol in humans. PubMed ID: 12077124

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. PubMed ID: 14640697

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. PubMed ID: 25017465

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. PubMed ID: 28190002

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. PubMed ID: 18621681

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. PubMed ID: 20667828

Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. PubMed ID: 23288837