Details for: LILRB1

Gene ID: 10859

Symbol: LILRB1

Ensembl ID: ENSG00000104972

Description: leukocyte immunoglobulin like receptor B1

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Amyloid-beta binding
    (GO:0001540)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasm
    (GO:0005737)
  • Defense response to virus
    (GO:0051607)
  • Dendritic cell differentiation
    (GO:0097028)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Fc receptor mediated inhibitory signaling pathway
    (GO:0002774)
  • Hla-a specific inhibitory mhc class i receptor activity
    (GO:0030107)
  • Hla-b specific inhibitory mhc class i receptor activity
    (GO:0030109)
  • Immune response-inhibiting cell surface receptor signaling pathway
    (GO:0002767)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Mhc class ib protein binding
    (GO:0023029)
  • Mhc class ib protein complex binding
    (GO:0023025)
  • Mhc class ib receptor activity
    (GO:0032394)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i receptor activity
    (GO:0032393)
  • Negative regulation of alpha-beta t cell activation
    (GO:0046636)
  • Negative regulation of calcium ion transport
    (GO:0051926)
  • Negative regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001186)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of dendritic cell differentiation
    (GO:2001199)
  • Negative regulation of endocytosis
    (GO:0045806)
  • Negative regulation of interferon-beta production
    (GO:0032688)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of mononuclear cell proliferation
    (GO:0032945)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of osteoclast development
    (GO:2001205)
  • Negative regulation of serotonin secretion
    (GO:0014063)
  • Negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:2001189)
  • Negative regulation of t cell mediated cytotoxicity
    (GO:0001915)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of transforming growth factor beta production
    (GO:0071635)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of gamma-delta t cell activation involved in immune response
    (GO:2001193)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein phosphatase 1 binding
    (GO:0008157)
  • Receptor internalization
    (GO:0031623)
  • Response to virus
    (GO:0009615)
  • Sh2 domain binding
    (GO:0042169)
  • Signal transduction
    (GO:0007165)
  • T cell proliferation involved in immune response
    (GO:0002309)

Other Information

Genular Protein ID: 1153032655

Symbol: LIRB1_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily B member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9259559

Title: A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors.

PubMed ID: 9259559

DOI: 10.1016/s0960-9822(06)00263-6

PubMed ID: 9285411

Title: A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.

PubMed ID: 9285411

DOI: 10.1016/s1074-7613(00)80529-4

PubMed ID: 10941837

Title: Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.

PubMed ID: 10941837

DOI: 10.1007/s002510000183

PubMed ID: 19658091

Title: Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.

PubMed ID: 19658091

DOI: 10.1002/eji.200839080

PubMed ID: 20600445

Title: LILRB1 polymorphism and surface phenotypes of natural killer cells.

PubMed ID: 20600445

DOI: 10.1016/j.humimm.2010.06.015

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9842885

Title: The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.

PubMed ID: 9842885

DOI: 10.1002/(sici)1521-4141(199811)28:11<3423::aid-immu3423>3.0.co;2-2

PubMed ID: 10591185

Title: The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18.

PubMed ID: 10591185

DOI: 10.1016/s1074-7613(00)80135-1

PubMed ID: 11907092

Title: Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.

PubMed ID: 11907092

DOI: 10.4049/jimmunol.168.7.3351

PubMed ID: 16455647

Title: Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

PubMed ID: 16455647

DOI: 10.1074/jbc.m512305200

PubMed ID: 19304799

Title: HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.

PubMed ID: 19304799

DOI: 10.1073/pnas.0901173106

PubMed ID: 20448110

Title: Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

PubMed ID: 20448110

DOI: 10.1182/blood-2009-07-234872

PubMed ID: 24453251

Title: Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses.

PubMed ID: 24453251

DOI: 10.4049/jimmunol.1300438

PubMed ID: 29262349

Title: Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

PubMed ID: 29262349

DOI: 10.1016/j.immuni.2017.11.018

PubMed ID: 28636952

Title: Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

PubMed ID: 28636952

DOI: 10.1016/j.immuni.2017.06.002

PubMed ID: 11114384

Title: Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2).

PubMed ID: 11114384

DOI: 10.1016/s1074-7613(00)00071-6

Sequence Information:

  • Length: 650
  • Mass: 70819
  • Checksum: 549196EA4ED2767C
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTALWI TRIPQELVKK GQFPIPSITW EHAGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VILQCDSQVA FDGFSLCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF 
    LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ 
    PEDGVEMDTR SPHDEDPQAV TYAEVKHSRP RREMASPPSP LSGEFLDTKD RQAEEDRQMD 
    TEAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEGPSPAV PSIYATLAIH

Genular Protein ID: 121305181

Symbol: A0A087WSV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 652
  • Mass: 71047
  • Checksum: 0A1F1E01C09F58FC
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    GPSGGPSSPT TGPTSTSAGP EDQPLTPTGS DPQSGLGRHL GVVIGILVAV ILLLLLLLLL 
    FLILRHRRQG KHWTSTQRKA DFQHPAGAVG PEPTDRGLQW RSSPAADAQE ENLYAAVKHT 
    QPEDGVEMDT RQSPHDEDPQ AVTYAEVKHS RPRREMASPP SPLSGEFLDT KDRQAEEDRQ 
    MDTEAAASEA PQDVTYAQLH SLTLRREATE PPPSQEGPSP AVPSIYATLA IH

Genular Protein ID: 159907260

Symbol: A8MVE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 634
  • Mass: 69462
  • Checksum: 7917B74BD4FC8721
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    AGPEDQPLTP TGSDPQSGLG RHLGVVIGIL VAVILLLLLL LLLFLILRHR RQGKHWTSTQ 
    RKADFQHPAG AVGPEPTDRG LQWRSSPAAD AQEENLYAAV KHTQPEDGVE MDTRSPHDED 
    PQAVTYAEVK HSRPRREMAS PPSPLSGEFL DTKDRQAEED RQMDTEAAAS EAPQDVTYAQ 
    LHSLTLRREA TEPPPSQEGP SPAVPSIYAT LAIH

Genular Protein ID: 332948196

Symbol: D9IDM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 20600445

Title: LILRB1 polymorphism and surface phenotypes of natural killer cells.

PubMed ID: 20600445

DOI: 10.1016/j.humimm.2010.06.015

Sequence Information:

  • Length: 651
  • Mass: 70976
  • Checksum: 82F752D3CE2DA351
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF 
    LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ 
    PEDGVEMDTR QSPHDEDPQA VTYAEVKHSR PRREMASPPS PLSGEFLDTK DRQAEEDRQM 
    DTEAAASEAP QDVTYAQLHS LTLRREATEP PPSQEGPSPA VPSIYATLAI H

Genular Protein ID: 2528621575

Symbol: A0A0B4J1W1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 650
  • Mass: 70847
  • Checksum: D5924C5782B386BB
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF 
    LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ 
    PEDGVEMDTR SPHDEDPQAV TYAEVKHSRP RREMASPPSP LSGEFLDTKD RQAEEDRQMD 
    TEAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEGPSPAV PSIYATLAIH

Genular Protein ID: 2038468171

Symbol: A0A087WSX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 651
  • Mass: 70918
  • Checksum: CDDE9E5930482B56
  • Sequence:
  • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 
    YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG 
    AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA 
    IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 
    TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 
    HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 
    GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 
    GPSGGPSSPT TGPTSTSAGP EDQPLTPTGS DPQSGLGRHL GVVIGILVAV ILLLLLLLLL 
    FLILRHRRQG KHWTSTQRKA DFQHPAGAVG PEPTDRGLQW RSSPAADAQE ENLYAAVKHT 
    QPEDGVEMDT RSPHDEDPQA VTYAEVKHSR PRREMASPPS PLSGEFLDTK DRQAEEDRQM 
    DTEAAASEAP QDVTYAQLHS LTLRREATEP PPSQEGPSPA VPSIYATLAI H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.