Details for: SLC26A1

Gene ID: 10861

Symbol: SLC26A1

Ensembl ID: ENSG00000145217

Description: solute carrier family 26 member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2,896
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.15
    Marker Score: 363
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.77
    Marker Score: 2,517
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 554
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.68
    Marker Score: 12,065
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1,353
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9,063
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 346
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.49
    Marker Score: 159
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 150
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 905
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 252
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.26
    Marker Score: 400
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.23
    Marker Score: 144
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 105
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.17
    Marker Score: 119
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.15
    Marker Score: 659
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.15
    Marker Score: 217
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 531
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.14
    Marker Score: 199
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.14
    Marker Score: 106
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.13
    Marker Score: 852
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.11
    Marker Score: 3,875
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1
    Marker Score: 105
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 135
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 828
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.09
    Marker Score: 481
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.09
    Marker Score: 68
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 127
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 780
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.08
    Marker Score: 740
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.07
    Marker Score: 4,563
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.07
    Marker Score: 295
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.07
    Marker Score: 100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 276
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.07
    Marker Score: 343
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.06
    Marker Score: 239
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.06
    Marker Score: 203
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 73

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SLC26A1 is a member of the solute carrier family 26 (SLC26) and is characterized by its ability to transport a wide range of anions across cell membranes. The gene product, Sulfate Anion Transporter 1 (S26A1_HUMAN), is a type II transmembrane protein that consists of 10 transmembrane domains and 6 cytosolic domains. SLC26A1 is expressed in various tissues, including the kidney, brain, and intestine, and is highly regulated by various signaling pathways. **Pathways and Functions** SLC26A1 is involved in several key pathways, including: 1. **Bicarbonate transport**: SLC26A1 regulates the transport of bicarbonate ions across the plasma membrane, which is essential for maintaining acid-base balance in the body. 2. **Chloride transport**: SLC26A1 also transports chloride ions across the plasma membrane, which is important for maintaining fluid balance and regulating blood pressure. 3. **Sulfate transport**: SLC26A1 is responsible for the transport of sulfate ions across the plasma membrane, which is essential for various physiological processes, including the synthesis of glycosaminoglycans and the regulation of neurotransmission. 4. **Glycosaminoglycan metabolism**: SLC26A1 is involved in the regulation of glycosaminoglycan metabolism, which is essential for maintaining tissue homeostasis and regulating inflammation. 5. **Ion homeostasis**: SLC26A1 helps maintain ion homeostasis by regulating the transport of ions across the plasma membrane, which is essential for maintaining proper physiological function. **Clinical Significance** Dysregulation of SLC26A1 has been implicated in various diseases, including: 1. **Kidney disease**: Mutations in SLC26A1 have been associated with kidney disease, including cystic kidney disease and polycystic kidney disease. 2. **Metabolic disorders**: SLC26A1 dysfunction has been implicated in metabolic disorders, including obesity and diabetes. 3. **Neurological disorders**: SLC26A1 has been implicated in neurological disorders, including epilepsy and schizophrenia. 4. **Cancer**: SLC26A1 has been implicated in cancer, including colorectal cancer and breast cancer. In conclusion, SLC26A1 is a multifunctional anion exchanger that plays a crucial role in maintaining ion homeostasis, regulating metabolism, and regulating neurotransmission. Dysregulation of SLC26A1 has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 144275233

Symbol: S26A1_HUMAN

Name: Sulfate anion transporter 1

UniProtKB Accession Codes:

Q9H2B4 A8K9N2 Q7Z5R3 Q96BK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11087667

Title: Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

PubMed ID: 11087667

DOI: 10.1006/geno.2000.6355

PubMed ID: 12713736

Title: Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1).

PubMed ID: 12713736

DOI: 10.1089/104454903321515913

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27125215

Title: Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport.

PubMed ID: 27125215

DOI: 10.1007/s00424-016-1823-8

PubMed ID: 27210743

Title: Mutations in SLC26A1 Cause Nephrolithiasis.

PubMed ID: 27210743

DOI: 10.1016/j.ajhg.2016.03.026

Sequence Information:

  • Length: 701
  • Mass: 75016
  • Checksum: A37E9E3D232043AD
  • Sequence:
    • MDESPEPLQQ GRGPVPVRRQ RPAPRGLREM LKARLWCSCS CSVLCVRALV QDLLPATRWL 
RQYRPREYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH 
VSVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DGLQPGANSS TLNGSAAMLD CGRDCYAIRV 
ATALTLMTGL YQVLMGVLRL GFVSAYLSQP LLDGFAMGAS VTILTSQLKH LLGVRIPRHQ 
GPGMVVLTWL SLLRGAGQAN VCDVVTSTVC LAVLLAAKEL SDRYRHRLRV PLPTELLVIV 
VATLVSHFGQ LHKRFGSSVA GDIPTGFMPP QVPEPRLMQR VALDAVALAL VAAAFSISLA 
EMFARSHGYS VRANQELLAV GCCNVLPAFL HCFATSAALA KSLVKTATGC RTQLSSVVSA 
TVVLLVLLAL APLFHDLQRS VLACVIVVSL RGALRKVWDL PRLWRMSPAD ALVWAGTAAT 
CMLVSTEAGL LAGVILSLLS LAGRTQRPRT ALLARIGDTA FYEDATEFEG LVPEPGVRVF 
RFGGPLYYAN KDFFLQSLYS LTGLDAGCMA ARRKEGGSET GVGEGGPAQG EDLGPVSTRA 
ALVPAAAGFH TVVIDCAPLL FLDAAGVSTL QDLRRDYGAL GISLLLACCS PPVRDILSRG 
GFLGEGPGDT AEEEQLFLSV HDAVQTARAR HRELEATDAH L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.