Details for: ADAM28

Gene ID: 10863

Symbol: ADAM28

Ensembl ID: ENSG00000042980

Description: ADAM metallopeptidase domain 28

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.94
    Marker Score: 1,425
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.08
    Marker Score: 1,533
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.53
    Marker Score: 18,825
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.47
    Marker Score: 1,649
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.43
    Marker Score: 1,198
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.39
    Marker Score: 4,359
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.2
    Marker Score: 2,165
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.14
    Marker Score: 4,482
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.98
    Marker Score: 571
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.79
    Marker Score: 732
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.75
    Marker Score: 1,057
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.73
    Marker Score: 473
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.66
    Marker Score: 1,482
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.65
    Marker Score: 583
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.6
    Marker Score: 1,214
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.6
    Marker Score: 3,638
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.58
    Marker Score: 2,892
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,146
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.52
    Marker Score: 9,693
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.42
    Marker Score: 410
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.4
    Marker Score: 1,318
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.35
    Marker Score: 1,466
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2,430
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.25
    Marker Score: 319
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.08
    Marker Score: 503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.94
    Marker Score: 1,097
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,232
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.9
    Marker Score: 7,594
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.88
    Marker Score: 369
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.88
    Marker Score: 536
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1,777
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.86
    Marker Score: 821
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.86
    Marker Score: 734
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.85
    Marker Score: 589
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.84
    Marker Score: 2,490
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.81
    Marker Score: 2,107
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.78
    Marker Score: 290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,234
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.77
    Marker Score: 10,169
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.77
    Marker Score: 557
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.77
    Marker Score: 388
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 787
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.73
    Marker Score: 948
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.73
    Marker Score: 427
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.73
    Marker Score: 358
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.71
    Marker Score: 484
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.68
    Marker Score: 1,051
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.67
    Marker Score: 749
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.66
    Marker Score: 1,064
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.65
    Marker Score: 963
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 391
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 204
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.63
    Marker Score: 564
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9,833
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.61
    Marker Score: 257
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.61
    Marker Score: 623
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.61
    Marker Score: 321
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.59
    Marker Score: 1,035
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.59
    Marker Score: 1,458
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.58
    Marker Score: 203
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.57
    Marker Score: 198
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 316
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 707
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.53
    Marker Score: 264
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.52
    Marker Score: 124
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.51
    Marker Score: 263
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.51
    Marker Score: 344
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.5
    Marker Score: 149
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.5
    Marker Score: 554
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.49
    Marker Score: 99
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.49
    Marker Score: 556
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.49
    Marker Score: 5,647
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.48
    Marker Score: 324
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.48
    Marker Score: 208
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.48
    Marker Score: 130
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.47
    Marker Score: 453
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1,105
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.47
    Marker Score: 116
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.46
    Marker Score: 4,368
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.46
    Marker Score: 535
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.45
    Marker Score: 329

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM28 is a 644-amino acid protein that belongs to the ADAM family, characterized by the presence of a disintegrin domain, a metalloproteinase domain, and a cysteine-rich domain. This unique combination of domains enables ADAM28 to interact with various ligands, including proteins, lipids, and carbohydrates, thereby modulating multiple cellular processes. Notably, ADAM28 exhibits a high degree of tissue specificity, with its expression being restricted to specific cell types, including mature microglial cells, central nervous system macrophages, and epithelial cells. **Pathways and Functions:** ADAM28's involvement in various biological pathways underscores its multifaceted role in immune regulation and beyond. Some of the key pathways and functions associated with ADAM28 include: 1. **Proteolysis and Metalloendopeptidase Activity:** ADAM28's metalloendopeptidase domain enables it to cleave and process proteins, influencing signaling pathways and cell-cell interactions. 2. **Cell Adhesion and Migration:** ADAM28's disintegrin domain facilitates cell adhesion and migration, contributing to processes such as immune cell trafficking and tissue remodeling. 3. **Spermatogenesis:** ADAM28's expression in spermatogenic cells highlights its potential role in reproductive biology. 4. **Neuroinflammation:** ADAM28's presence in the central nervous system and its interaction with immune cells suggest a role in neuroinflammation and immune regulation. 5. **Cancer Metastasis:** ADAM28's involvement in cell adhesion and migration processes may also contribute to cancer metastasis. **Clinical Significance:** ADAM28's involvement in various biological processes has significant implications for human health and disease. Some of the potential clinical applications and implications of ADAM28 include: 1. **Neurodegenerative Diseases:** ADAM28's role in neuroinflammation and immune regulation may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** ADAM28's involvement in cell adhesion and migration processes may influence cancer progression and metastasis. 3. **Autoimmune Diseases:** ADAM28's interaction with immune cells and its expression in immune cells may contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Reproductive Biology:** ADAM28's role in spermatogenesis highlights its potential as a biomarker for male infertility or reproductive disorders. In conclusion, ADAM28 is a multifunctional protein with a wide range of biological activities, from immune regulation to reproductive biology. Further research is necessary to fully elucidate the mechanisms underlying ADAM28's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3573127649

Symbol: ADA28_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 28

UniProtKB Accession Codes:

Q9UKQ2 B2RMV5 Q9Y339 Q9Y3S0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10506182

Title: MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes.

PubMed ID: 10506182

DOI: 10.1074/jbc.274.41.29251

PubMed ID: 10587367

Title: Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis.

PubMed ID: 10587367

DOI: 10.1093/molehr/5.12.1127

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21618342

Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

PubMed ID: 21618342

DOI: 10.1002/humu.21477

Sequence Information:

  • Length: 775
  • Mass: 87148
  • Checksum: 895E0985840F971C
  • Sequence:
    • MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ EQFETELKYK 
MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ IMDDCYYQGH ILNEKVSDAS 
ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG QEHALFKYNP DEKNYDSTCG MDGVLWAHDL 
QQNIALPATK LVKLKDRKVQ EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM 
LYKKLNTHVA LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE 
LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD DYSCKCPSTI 
CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL PTDIISTPIC GNQLVEMGED 
CDCGTSEECT NICCDAKTCK IKATFQCALG ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG 
KSGNCPDDRF QVNGFPCHHG KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK 
YGYCRRVDDT LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV 
ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG WIPPDCDDSS 
VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR PLSTTGTRPH KQKRKPQMVK 
AVQPQEMSQM KPHVYDLPVE GNEPPASFHK DTNALPPTVF KDNPVSTPKD SNPKA

Genular Protein ID: 785674887

Symbol: A0A384NKT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384NKT9

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 2 Pfam 3 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 540
  • Mass: 61232
  • Checksum: 65F475E18650D227
  • Sequence:
    • MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ EQFETELKYK 
MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ IMDDCYYQGH ILNEKVSDAS 
ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG QEHALFKYNP DEKNYDSTCG MDGVLWAHDL 
QQNIALPATK LVKLKDRKVQ EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM 
LYKKLNTHVA LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE 
LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD DYSCKCPSTI 
CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL PTDIISTPIC GNQLVEMGED 
CDCGTSEECT NICCDAKTCK IKATFQCALG ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG 
KSGNCPDDRF QVNGFPCHHG KGHCLMGTCP TLQEQCTELW GPGRRTNPFP CACAKENHFR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.