Details for: ARID5A

Gene ID: 10865

Symbol: ARID5A

Ensembl ID: ENSG00000196843

Description: AT-rich interaction domain 5A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.41
    Marker Score: 6,327
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.09
    Marker Score: 1,781
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.84
    Marker Score: 3,111
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.72
    Marker Score: 669
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.7
    Marker Score: 1,460
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.65
    Marker Score: 4,568
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.65
    Marker Score: 16,325
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.63
    Marker Score: 55,343
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.6
    Marker Score: 654
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.49
    Marker Score: 3,146
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.47
    Marker Score: 4,290
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.45
    Marker Score: 602
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.44
    Marker Score: 14,603
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.44
    Marker Score: 2,513
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.42
    Marker Score: 74,949
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.41
    Marker Score: 6,099
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.38
    Marker Score: 689
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.37
    Marker Score: 988
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.35
    Marker Score: 2,971
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.33
    Marker Score: 3,739
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.33
    Marker Score: 1,245
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.29
    Marker Score: 2,418
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.29
    Marker Score: 1,388
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.27
    Marker Score: 1,852
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.26
    Marker Score: 1,238
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.25
    Marker Score: 2,208
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.23
    Marker Score: 1,023
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.21
    Marker Score: 3,082
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.21
    Marker Score: 367
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.2
    Marker Score: 305
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.19
    Marker Score: 687
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.19
    Marker Score: 7,230
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.19
    Marker Score: 654
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.18
    Marker Score: 2,482
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.18
    Marker Score: 1,931
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.17
    Marker Score: 1,612
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,116
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.16
    Marker Score: 1,984
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.13
    Marker Score: 320
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.12
    Marker Score: 533
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.12
    Marker Score: 943
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.11
    Marker Score: 277
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.1
    Marker Score: 277
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.09
    Marker Score: 3,437
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.08
    Marker Score: 2,797
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.07
    Marker Score: 1,224
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.06
    Marker Score: 213
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.05
    Marker Score: 327
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.04
    Marker Score: 250
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.04
    Marker Score: 622
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.03
    Marker Score: 623
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.03
    Marker Score: 647
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.02
    Marker Score: 2,046
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.02
    Marker Score: 300
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.01
    Marker Score: 1,117
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,636
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,860
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.99
    Marker Score: 327
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.99
    Marker Score: 580
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,385
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.96
    Marker Score: 3,701
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.95
    Marker Score: 410
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.95
    Marker Score: 24,355
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.95
    Marker Score: 807
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.95
    Marker Score: 206
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,382
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.94
    Marker Score: 839
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.93
    Marker Score: 706
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.93
    Marker Score: 385
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.92
    Marker Score: 904
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.92
    Marker Score: 291
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.92
    Marker Score: 604
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.92
    Marker Score: 471
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.92
    Marker Score: 241
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.92
    Marker Score: 719
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.91
    Marker Score: 419
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.91
    Marker Score: 1,010
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.91
    Marker Score: 323
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.9
    Marker Score: 1,120
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.89
    Marker Score: 384
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.89
    Marker Score: 950
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.88
    Marker Score: 234
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.88
    Marker Score: 486
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.88
    Marker Score: 303
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.87
    Marker Score: 171
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.87
    Marker Score: 948
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.87
    Marker Score: 1,255
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.86
    Marker Score: 212
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.86
    Marker Score: 3,188
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,205
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.85
    Marker Score: 558
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 506
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.85
    Marker Score: 9,545
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.84
    Marker Score: 996
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.84
    Marker Score: 210

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARID5A is a member of the ARID family of proteins, characterized by the presence of AT-rich interaction domains. These domains enable the protein to bind to specific DNA sequences, thereby regulating gene expression. The gene is predominantly expressed in various cell types, including immune cells, such as T cells and natural killer cells, as well as non-immune cells like fibroblasts and endothelial cells. This widespread expression suggests that ARID5A plays a crucial role in maintaining cellular homeostasis and responding to environmental stimuli. **Pathways and Functions:** ARID5A is involved in numerous signaling pathways, including those related to immune response, transcriptional regulation, and cell differentiation. Notably, the gene is a key regulator of the transcriptional machinery, influencing the activity of RNA polymerase II and the binding of transcription factors to specific DNA sequences. ARID5A also interacts with various transcriptional co-repressors and co-activators, modulating the expression of genes involved in immune response, inflammation, and cell survival. In the context of immune response, ARID5A is essential for regulating the production of cytokines, such as interleukin-6 (IL-6) and interleukin-17 (IL-17), which are critical for the activation and differentiation of immune cells. Additionally, ARID5A modulates the activity of transcription factors, including nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT), which play key roles in regulating immune responses. **Clinical Significance:** Dysregulation of ARID5A has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory conditions. For instance, alterations in ARID5A expression have been observed in patients with rheumatoid arthritis, multiple sclerosis, and other autoimmune diseases. Furthermore, ARID5A has been identified as a tumor suppressor gene in certain types of cancer, including prostate cancer, where its expression is often downregulated. In addition, ARID5A has been shown to play a critical role in the regulation of immune responses during pregnancy, where its expression is essential for maintaining immune tolerance and preventing miscarriage. Dysregulation of ARID5A has also been implicated in inflammatory conditions, such as atherosclerosis and inflammatory bowel disease, where its expression is often altered. **Conclusion:** In conclusion, ARID5A is a complex gene that plays a multifaceted role in regulating immune response, transcriptional regulation, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis. Further research is necessary to fully elucidate the mechanisms by which ARID5A regulates immune responses and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which ARID5A regulates immune responses and transcriptional regulation. 2. The identification of specific ARID5A-binding sites and their role in regulating gene expression will provide valuable insights into the function of this gene. 3. The development of therapeutic strategies targeting ARID5A may offer new approaches for treating autoimmune disorders, cancer, and inflammatory conditions. **Future Directions:** 1. Investigating the role of ARID5A in regulating immune responses during pregnancy and its potential implications in reproductive health. 2. Exploring the relationship between ARID5A expression and the development of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 3. Investigating the potential of ARID5A as a therapeutic target for various diseases, including cancer and inflammatory conditions.

Genular Protein ID: 3764103044

Symbol: ARI5A_HUMAN

Name: AT-rich interactive domain-containing protein 5A

UniProtKB Accession Codes:

Q03989 C9J1Q0 Q6NX37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8649988

Title: Repression by a differentiation-specific factor of the human cytomegalovirus enhancer.

PubMed ID: 8649988

DOI: 10.1093/nar/24.9.1695

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15941852

Title: Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha.

PubMed ID: 15941852

DOI: 10.1210/me.2004-0311

Sequence Information:

  • Length: 594
  • Mass: 64074
  • Checksum: 89A494C4560416FF
  • Sequence:
    • MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE EEQEREEEQA 
FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG AYELVTGRRL WKNVYDELGG 
SPGSTSAATC TRRHYERLVL PYVRHLKGED DKPLPTSKPR KQYKMAKENR GDDGATERPK 
KAKEERRMDQ MMPGKTKADA ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK 
RLLSSFYCKG THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS 
PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE VLKPVSQHPR 
DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH KGGSRKGILY PKPKACWVSP 
MAKVPAESPT LPPTFPSSPG LGSKRSLEEE GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG 
SGLVSCLLGP ALGPVPPEAY RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA 
TAGPSPMAAG LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.