Details for: HCP5

Gene ID: 10866

Symbol: HCP5

Ensembl ID: ENSG00000206337

Description: HLA complex P5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HCP5 gene is a non-coding gene, meaning it does not encode a protein. Instead, it is involved in regulating gene expression and controlling the activity of nearby genes. The gene's expression is restricted to specific cell types, including CD16-positive natural killer cells, CD56-dim natural killer cells, and CD4-positive and CD8-positive T cells. This restricted expression pattern is consistent with the gene's involvement in immune function and cell signaling. **Pathways and Functions** The HCP5 gene is thought to regulate the expression of nearby genes, including those involved in immune response and cell signaling. One possible mechanism is through the regulation of microRNA (miRNA) expression. miRNAs are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. The HCP5 gene may act as a miRNA sponge, binding to and regulating the expression of nearby miRNAs that are involved in immune function. In addition to its regulatory role, the HCP5 gene may also be involved in cell signaling pathways, including those involved in immune response and cell proliferation. The gene's expression in endothelial cells and natural killer cells suggests its involvement in cell-cell interactions and tissue homeostasis. **Clinical Significance** The HCP5 gene's expression in various cell types and its regulatory role in immune function and cell signaling make it an interesting candidate for studying immune-related diseases. For example, alterations in HCP5 gene expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, the gene's expression in endothelial cells may be involved in the development of cardiovascular diseases. Furthermore, the HCP5 gene's involvement in cell signaling pathways may make it a target for cancer therapy. For example, the gene's expression in T cells may be involved in the regulation of immune response to cancer cells. Understanding the HCP5 gene's role in immune function and cell signaling may provide new insights into the development of immunotherapies for cancer and autoimmune diseases. In conclusion, the HCP5 gene is a non-coding gene that plays a crucial role in regulating immune function and cell signaling. Its expression in various cell types and its regulatory role in nearby genes make it an interesting candidate for studying immune-related diseases. Further research is needed to fully understand the HCP5 gene's role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.