Details for: TSPAN9

Gene ID: 10867

Symbol: TSPAN9

Ensembl ID: ENSG00000011105

Description: tetraspanin 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.89
    Marker Score: 3,494
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.57
    Marker Score: 10,773
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.5
    Marker Score: 1,316
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.49
    Marker Score: 1,456
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.45
    Marker Score: 3,301
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.36
    Marker Score: 52,679
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.21
    Marker Score: 1,706
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.18
    Marker Score: 7,131
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.17
    Marker Score: 686
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.1
    Marker Score: 659
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.1
    Marker Score: 4,035
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.08
    Marker Score: 3,016
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.03
    Marker Score: 1,211
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.02
    Marker Score: 74,575
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2
    Marker Score: 1,114
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.99
    Marker Score: 1,638
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.98
    Marker Score: 829
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.98
    Marker Score: 672
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.8
    Marker Score: 7,448
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.77
    Marker Score: 5,924
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.76
    Marker Score: 1,326
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.73
    Marker Score: 4,072
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.73
    Marker Score: 6,136
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.72
    Marker Score: 504
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.7
    Marker Score: 818
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.7
    Marker Score: 3,723
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.69
    Marker Score: 7,068
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.66
    Marker Score: 1,578
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.63
    Marker Score: 5,788
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.57
    Marker Score: 23,538
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.57
    Marker Score: 1,804
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.53
    Marker Score: 419
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.48
    Marker Score: 539
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.48
    Marker Score: 1,583
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.47
    Marker Score: 7,917
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2,953
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.45
    Marker Score: 1,254
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.44
    Marker Score: 806
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.43
    Marker Score: 745
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.41
    Marker Score: 3,784
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.41
    Marker Score: 10,803
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.38
    Marker Score: 803
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.38
    Marker Score: 12,092
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.37
    Marker Score: 21,462
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.37
    Marker Score: 8,802
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.34
    Marker Score: 5,765
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.32
    Marker Score: 7,107
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.31
    Marker Score: 1,388
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.27
    Marker Score: 1,439
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.26
    Marker Score: 714
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.24
    Marker Score: 47,173
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.23
    Marker Score: 1,360
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.23
    Marker Score: 1,738
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1,301
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.19
    Marker Score: 1,436
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.17
    Marker Score: 4,600
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.16
    Marker Score: 532
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71,519
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.12
    Marker Score: 272
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.11
    Marker Score: 995
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.09
    Marker Score: 939
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.08
    Marker Score: 959
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.07
    Marker Score: 4,137
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.05
    Marker Score: 6,332
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.04
    Marker Score: 384
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.01
    Marker Score: 278
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.01
    Marker Score: 700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.01
    Marker Score: 2,538
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1
    Marker Score: 1,012
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,987
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.99
    Marker Score: 473
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19,691
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.99
    Marker Score: 1,356
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.98
    Marker Score: 620
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.98
    Marker Score: 1,265
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.97
    Marker Score: 9,802
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.97
    Marker Score: 1,686
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.96
    Marker Score: 346
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.96
    Marker Score: 1,595
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.96
    Marker Score: 577
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.96
    Marker Score: 599
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.96
    Marker Score: 2,435
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.94
    Marker Score: 227
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.94
    Marker Score: 31,883
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.93
    Marker Score: 999
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.91
    Marker Score: 9,418
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.91
    Marker Score: 857
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.91
    Marker Score: 3,911
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1,124
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.89
    Marker Score: 3,445

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSN9 is a 67-kDa protein with four transmembrane domains, which are characteristic of the tetraspanin family. Its expression is widespread across different tissues, including the lens, retina, kidney, heart, and smooth muscle cells. TSN9 is also highly expressed in cells that are involved in immune responses, such as dendritic cells and macrophages. Notably, TSN9 is predominantly localized to the plasma membrane, where it interacts with other proteins to form tetraspanin-enriched microdomains (TEMDs). These domains are critical for regulating cell-cell interactions, adhesion, and signaling pathways. **Pathways and Functions:** TSN9 plays a crucial role in regulating various cellular processes, including: 1. **Focal Adhesion:** TSN9 interacts with integrins and other adhesion molecules to regulate focal adhesion formation and dynamics. This interaction is essential for cell migration, proliferation, and survival. 2. **Cell Migration:** TSN9 modulates cell migration by regulating the activity of integrins and other adhesion molecules. This is critical for processes such as wound healing, immune responses, and tissue development. 3. **Immune Responses:** TSN9 is highly expressed in immune cells, such as dendritic cells and macrophages, where it regulates immune cell adhesion, migration, and activation. 4. **Cell Signaling:** TSN9 interacts with various signaling molecules, including integrins, growth factor receptors, and G-protein coupled receptors, to regulate cell growth, differentiation, and survival. **Clinical Significance:** TSN9 has been implicated in various diseases, including: 1. **Cancer:** TSN9 expression is altered in various types of cancer, including breast, lung, and colon cancer. Its expression is often associated with tumor progression and metastasis. 2. **Neurological Disorders:** TSN9 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates cell migration and adhesion. 3. **Cardiovascular Diseases:** TSN9 expression is altered in cardiovascular diseases, such as atherosclerosis and heart failure, where it regulates cell migration and adhesion. In conclusion, TSPAN9 is a critical component of cell adhesion and signaling in various tissues. Its expression is highly regulated and is implicated in various diseases. Further studies are needed to fully understand the role of TSN9 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3007072258

Symbol: TSN9_HUMAN

Name: Tetraspanin-9

UniProtKB Accession Codes:

O75954 D3DUQ7 Q53FV2 Q6FGJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10719184

Title: Sequence and expression of seven new tetraspans.

PubMed ID: 10719184

DOI: 10.1016/s0167-4838(00)00022-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18795891

Title: Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains.

PubMed ID: 18795891

DOI: 10.1042/bj20081126

Sequence Information:

  • Length: 239
  • Mass: 26779
  • Checksum: DD7BA332BF6584EB
  • Sequence:
    • MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS LSAANLVIAI 
GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL LILFFVYMDK VNENAKKDLK 
EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV TDYTDWYPVL GENTVPDRCC MENSQGCGRN 
ATTPLWRTGC YEKVKMWFDD NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.