Details for: USP20

Gene ID: 10868

Symbol: USP20

Ensembl ID: ENSG00000136878

Description: ubiquitin specific peptidase 20

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,967
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.38
    Marker Score: 14,272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.23
    Marker Score: 11,648
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.21
    Marker Score: 74,583
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2
    Marker Score: 2,105
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1,837
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10,212
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11,081
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42,765
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.15
    Marker Score: 4,439
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.12
    Marker Score: 1,242
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.08
    Marker Score: 40,981
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,758
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1
    Marker Score: 19,828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,983
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.99
    Marker Score: 14,807
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2,253
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.95
    Marker Score: 7,264
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.95
    Marker Score: 2,079
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.94
    Marker Score: 566
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9
    Marker Score: 1,715
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.89
    Marker Score: 3,709
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,045
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3,561
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.82
    Marker Score: 258
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3,322
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 341
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12,557
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.8
    Marker Score: 17,019
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,230
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 418
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,004
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 283
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 222
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 187
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.66
    Marker Score: 943
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.62
    Marker Score: 157
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6
    Marker Score: 726
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.59
    Marker Score: 2,170
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.58
    Marker Score: 784
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.58
    Marker Score: 2,674
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.58
    Marker Score: 1,589
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3,363
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.55
    Marker Score: 168
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 160
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.55
    Marker Score: 1,050
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.54
    Marker Score: 28,704
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 468
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.53
    Marker Score: 567
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.49
    Marker Score: 562
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.49
    Marker Score: 815
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 166
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.47
    Marker Score: 216
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.46
    Marker Score: 189
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 220
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.46
    Marker Score: 391
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.46
    Marker Score: 269
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.46
    Marker Score: 1,277
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 307
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.43
    Marker Score: 1,368
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.43
    Marker Score: 765
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.41
    Marker Score: 381
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.41
    Marker Score: 212
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 269
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.4
    Marker Score: 572
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.4
    Marker Score: 1,563
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.4
    Marker Score: 384
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.4
    Marker Score: 249
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.4
    Marker Score: 683
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.4
    Marker Score: 261
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.4
    Marker Score: 776
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.39
    Marker Score: 340
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.39
    Marker Score: 263
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.39
    Marker Score: 77
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.39
    Marker Score: 440
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.39
    Marker Score: 955
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.39
    Marker Score: 471
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.39
    Marker Score: 3,842
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.39
    Marker Score: 187
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.38
    Marker Score: 2,457
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.38
    Marker Score: 81
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.38
    Marker Score: 277

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP20 is a 56-kDa protein that belongs to the USP family of DUBs. It is characterized by its ability to recognize and remove ubiquitin and ubiquitin-like modifiers, such as SUMO and PIAS, from target proteins. USP20 is highly specific, with a preference for removing ubiquitin from proteins that are targeted for degradation by the 26S proteasome. The protein is highly expressed in various cell types, including mural cells, dopaminergic neurons, and corticothalamic-projecting glutamatergic cortical neurons. **Pathways and Functions:** USP20 is involved in several cellular pathways, including: 1. **Antiviral Innate Immune Response:** USP20 has been shown to play a critical role in the regulation of antiviral innate immune response by removing ubiquitin from key immune proteins, such as ISG15 and IRF3. 2. **Autophagy:** USP20 has been implicated in the regulation of autophagy, a cellular process that involves the degradation and recycling of cellular components. 3. **Protein Degradation:** USP20 is involved in the regulation of protein degradation by removing ubiquitin from target proteins, which is essential for maintaining protein homeostasis. 4. **G Protein-Coupled Receptor Signaling:** USP20 has been shown to regulate G protein-coupled receptor signaling by removing ubiquitin from key receptors, such as the β2-adrenergic receptor. **Clinical Significance:** USP20 has been implicated in various diseases, including: 1. **Antiviral Diseases:** USP20 has been shown to play a critical role in the regulation of antiviral innate immune response, making it a potential target for the treatment of antiviral diseases. 2. **Neurodegenerative Diseases:** USP20 has been implicated in the regulation of protein degradation and autophagy, which are critical processes in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cancer:** USP20 has been shown to regulate protein degradation and autophagy in cancer cells, making it a potential target for the treatment of cancer. In conclusion, USP20 is a key regulator of protein degradation, immune response, and various cellular processes. Its involvement in antiviral innate immune response, autophagy, and protein degradation makes it a critical protein in maintaining cellular homeostasis. Further studies are needed to fully elucidate the mechanisms of USP20 and its potential implications in various diseases.

Genular Protein ID: 2523111887

Symbol: UBP20_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12056827

Title: Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.

PubMed ID: 12056827

DOI: 10.1016/s0006-291x(02)00534-x

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10369878

Title: Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.

PubMed ID: 10369878

DOI: 10.1093/hmg/8.7.1313

PubMed ID: 12865408

Title: Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.

PubMed ID: 12865408

DOI: 10.1172/jci18348

PubMed ID: 15776016

Title: VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.

PubMed ID: 15776016

DOI: 10.1038/sj.embor.7400377

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19424180

Title: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

PubMed ID: 19424180

DOI: 10.1038/emboj.2009.128

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23486064

Title: USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

PubMed ID: 23486064

DOI: 10.1038/nature11941

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26839314

Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation.

PubMed ID: 26839314

DOI: 10.1074/jbc.m115.687129

PubMed ID: 27801882

Title: USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

PubMed ID: 27801882

DOI: 10.1038/cr.2016.125

PubMed ID: 29487085

Title: The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.

PubMed ID: 29487085

DOI: 10.15252/embr.201744378

PubMed ID: 32354117

Title: The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaB Signaling Pathway through Stabilization of p62.

PubMed ID: 32354117

DOI: 10.3390/ijms21093116

PubMed ID: 33792613

Title: Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.

PubMed ID: 33792613

DOI: 10.1083/jcb.202004086

PubMed ID: 35063767

Title: The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.

PubMed ID: 35063767

DOI: 10.1016/j.bbrc.2022.01.019

Sequence Information:

  • Length: 914
  • Mass: 102003
  • Checksum: DC094570A396D20E
  • Sequence:
  • MGDSRDLCPH LDSIGEVTKE DLLLKSKGTC QSCGVTGPNL WACLQVACPY VGCGESFADH 
    STIHAQAKKH NLTVNLTTFR LWCYACEKEV FLEQRLAAPL LGSSSKFSEQ DSPPPSHPLK 
    AVPIAVADEG ESESEDDDLK PRGLTGMKNL GNSCYMNAAL QALSNCPPLT QFFLECGGLV 
    RTDKKPALCK SYQKLVSEVW HKKRPSYVVP TSLSHGIKLV NPMFRGYAQQ DTQEFLRCLM 
    DQLHEELKEP VVATVALTEA RDSDSSDTDE KREGDRSPSE DEFLSCDSSS DRGEGDGQGR 
    GGGSSQAETE LLIPDEAGRA ISEKERMKDR KFSWGQQRTN SEQVDEDADV DTAMAALDDQ 
    PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP RASPVRMAPS 
    YVLKKAQVLS AGSRRRKEQR YRSVISDIFD GSILSLVQCL TCDRVSTTVE TFQDLSLPIP 
    GKEDLAKLHS AIYQNVPAKP GACGDSYAAQ GWLAFIVEYI RRFVVSCTPS WFWGPVVTLE 
    DCLAAFFAAD ELKGDNMYSC ERCKKLRNGV KYCKVLRLPE ILCIHLKRFR HEVMYSFKIN 
    SHVSFPLEGL DLRPFLAKEC TSQITTYDLL SVICHHGTAG SGHYIAYCQN VINGQWYEFD 
    DQYVTEVHET VVQNAEGYVL FYRKSSEEAM RERQQVVSLA AMREPSLLRF YVSREWLNKF 
    NTFAEPGPIT NQTFLCSHGG IPPHKYHYID DLVVILPQNV WEHLYNRFGG GPAVNHLYVC 
    SICQVEIEAL AKRRRIEIDT FIKLNKAFQA EESPGVIYCI SMQWFREWEA FVKGKDNEPP 
    GPIDNSRIAQ VKGSGHVQLK QGADYGQISE ETWTYLNSLY GGGPEIAIRQ SVAQPLGPEN 
    LHGEQKIEAE TRAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.