USP20 | ENSG00000136878 | NCBI 10868

Details for: USP20

Gene ID: 10868

Symbol: USP20

Ensembl ID: ENSG00000136878

Description: ubiquitin specific peptidase 20

Associated with

Deubiquitination
(R-HSA-5688426)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Ub-specific processing proteases
(R-HSA-5689880)
Antiviral innate immune response
(GO:0140374)
Centrosome
(GO:0005813)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
G protein-coupled receptor binding
(GO:0001664)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of autophagy
(GO:0010508)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Protein k48-linked deubiquitination
(GO:0071108)
Protein k63-linked deubiquitination
(GO:0070536)
Proteolysis
(GO:0006508)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 20

Genular Protein ID: 2523111887

Symbol: UBP20_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 20

UniProtKB Accession Codes:

Q9Y2K6 Q541F1 Q8IXQ1 Q96LG5 Q9UQN8 Q9UQP0

Database IDs:

Citations:

PubMed ID: 12056827

Title: Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.

PubMed ID: 12056827

DOI: 10.1016/s0006-291x(02)00534-x

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10369878

Title: Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.

PubMed ID: 10369878

DOI: 10.1093/hmg/8.7.1313

PubMed ID: 12865408

Title: Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.

PubMed ID: 12865408

DOI: 10.1172/jci18348

PubMed ID: 15776016

Title: VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.

PubMed ID: 15776016

DOI: 10.1038/sj.embor.7400377

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19424180

Title: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

PubMed ID: 19424180

DOI: 10.1038/emboj.2009.128

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23486064

Title: USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

PubMed ID: 23486064

DOI: 10.1038/nature11941

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26839314

Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation.

PubMed ID: 26839314

DOI: 10.1074/jbc.m115.687129

PubMed ID: 27801882

Title: USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

PubMed ID: 27801882

DOI: 10.1038/cr.2016.125

PubMed ID: 29487085

Title: The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.

PubMed ID: 29487085

DOI: 10.15252/embr.201744378

PubMed ID: 32354117

Title: The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaB Signaling Pathway through Stabilization of p62.

PubMed ID: 32354117

DOI: 10.3390/ijms21093116

PubMed ID: 33792613

Title: Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.

PubMed ID: 33792613

DOI: 10.1083/jcb.202004086

PubMed ID: 35063767

Title: The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.

PubMed ID: 35063767

DOI: 10.1016/j.bbrc.2022.01.019

Sequence Information:

Length: 914
Mass: 102003
Checksum: DC094570A396D20E
Sequence:

MGDSRDLCPH LDSIGEVTKE DLLLKSKGTC QSCGVTGPNL WACLQVACPY VGCGESFADH 
STIHAQAKKH NLTVNLTTFR LWCYACEKEV FLEQRLAAPL LGSSSKFSEQ DSPPPSHPLK 
AVPIAVADEG ESESEDDDLK PRGLTGMKNL GNSCYMNAAL QALSNCPPLT QFFLECGGLV 
RTDKKPALCK SYQKLVSEVW HKKRPSYVVP TSLSHGIKLV NPMFRGYAQQ DTQEFLRCLM 
DQLHEELKEP VVATVALTEA RDSDSSDTDE KREGDRSPSE DEFLSCDSSS DRGEGDGQGR 
GGGSSQAETE LLIPDEAGRA ISEKERMKDR KFSWGQQRTN SEQVDEDADV DTAMAALDDQ 
PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP RASPVRMAPS 
YVLKKAQVLS AGSRRRKEQR YRSVISDIFD GSILSLVQCL TCDRVSTTVE TFQDLSLPIP 
GKEDLAKLHS AIYQNVPAKP GACGDSYAAQ GWLAFIVEYI RRFVVSCTPS WFWGPVVTLE 
DCLAAFFAAD ELKGDNMYSC ERCKKLRNGV KYCKVLRLPE ILCIHLKRFR HEVMYSFKIN 
SHVSFPLEGL DLRPFLAKEC TSQITTYDLL SVICHHGTAG SGHYIAYCQN VINGQWYEFD 
DQYVTEVHET VVQNAEGYVL FYRKSSEEAM RERQQVVSLA AMREPSLLRF YVSREWLNKF 
NTFAEPGPIT NQTFLCSHGG IPPHKYHYID DLVVILPQNV WEHLYNRFGG GPAVNHLYVC 
SICQVEIEAL AKRRRIEIDT FIKLNKAFQA EESPGVIYCI SMQWFREWEA FVKGKDNEPP 
GPIDNSRIAQ VKGSGHVQLK QGADYGQISE ETWTYLNSLY GGGPEIAIRQ SVAQPLGPEN 
LHGEQKIEAE TRAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP20

Associated with

Other Information

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. PubMed ID: 12056827

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10231032

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. PubMed ID: 10369878

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. PubMed ID: 12865408

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. PubMed ID: 15776016

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. PubMed ID: 19424180

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors. PubMed ID: 23166351

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. PubMed ID: 23486064

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of beta-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor kappaB (NFkappaB) Activation. PubMed ID: 26839314

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. PubMed ID: 27801882

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation. PubMed ID: 29487085

The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaB Signaling Pathway through Stabilization of p62. PubMed ID: 32354117

Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins. PubMed ID: 33792613

The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein. PubMed ID: 35063767