Details for: USP19

Gene ID: 10869

Symbol: USP19

Ensembl ID: ENSG00000172046

Description: ubiquitin specific peptidase 19

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.14
    Marker Score: 1,993
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,766
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,991
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9
    Marker Score: 720
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,019
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11,677
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1,365
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,910
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 182
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.58
    Marker Score: 889
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.53
    Marker Score: 571
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.52
    Marker Score: 748
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.5
    Marker Score: 4,380
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.5
    Marker Score: 3,725
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.49
    Marker Score: 510
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.47
    Marker Score: 469
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1,266
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1,911
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.47
    Marker Score: 231
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.47
    Marker Score: 416
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.46
    Marker Score: 1,153
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.46
    Marker Score: 1,565
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.45
    Marker Score: 3,896
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.45
    Marker Score: 478
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.45
    Marker Score: 409
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.43
    Marker Score: 2,570
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 995
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.42
    Marker Score: 1,563
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.42
    Marker Score: 147
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.42
    Marker Score: 470
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 509
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.4
    Marker Score: 426
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4
    Marker Score: 24,484
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.4
    Marker Score: 265
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 238
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.39
    Marker Score: 161
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 127
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.39
    Marker Score: 386
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 3,989
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 237
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.39
    Marker Score: 732
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 560
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.38
    Marker Score: 385
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.38
    Marker Score: 859
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.38
    Marker Score: 3,774
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.37
    Marker Score: 206
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 361
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.37
    Marker Score: 612
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1,532
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.36
    Marker Score: 990
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.36
    Marker Score: 3,142
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3,375
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.35
    Marker Score: 165
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.35
    Marker Score: 1,251
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.35
    Marker Score: 263
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.35
    Marker Score: 159
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.35
    Marker Score: 491
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 349
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.34
    Marker Score: 218
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.34
    Marker Score: 74
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.34
    Marker Score: 163
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.34
    Marker Score: 1,054
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.34
    Marker Score: 824
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.33
    Marker Score: 77
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.33
    Marker Score: 12,063
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.32
    Marker Score: 221
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.32
    Marker Score: 1,556
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.32
    Marker Score: 3,049
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.32
    Marker Score: 682
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 129
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.32
    Marker Score: 159
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 512
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.32
    Marker Score: 336
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.32
    Marker Score: 78
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.31
    Marker Score: 17,613
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 403

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP19 exhibits several key characteristics that define its function and significance: 1. **Cysteine-type deubiquitination activity**: USP19's ability to remove ubiquitin tags from target proteins is mediated by its cysteine protease activity. 2. **Widespread expression**: USP19 is expressed in various cell types, including germ cells, neuronal cells, and epithelial cells, indicating its involvement in multiple cellular processes. 3. **Regulation of protein stability and localization**: USP19's deubiquitinating activity influences the stability, localization, and activity of target proteins, thereby modulating cellular responses to environmental cues. 4. **Interactions with other proteins**: USP19 interacts with various proteins, including Hsp90, metal ions, and other deubiquitinating enzymes, to fine-tune its regulatory functions. **Pathways and Functions:** USP19's deubiquitinating activity is embedded in several cellular pathways, including: 1. **Erad pathway**: USP19 regulates the ER-associated degradation (ERAD) pathway, which is responsible for the degradation of misfolded proteins in the endoplasmic reticulum. 2. **Protein stabilization and degradation**: USP19 modulates the stability and degradation of target proteins, influencing cellular responses to environmental stressors, such as hypoxia and endoplasmic reticulum stress. 3. **Cell cycle regulation**: USP19's deubiquitinating activity influences the regulation of the cell cycle, particularly during the G2/M phase. 4. **Metabolism of proteins**: USP19's involvement in protein degradation and stabilization processes affects the overall metabolism of proteins within the cell. **Clinical Significance:** USP19's dysregulation has been implicated in various diseases, including: 1. **Cancer**: USP19's role in regulating protein stability and localization may contribute to cancer progression and metastasis. 2. **Neurological disorders**: USP19's involvement in neuronal cell development and function may be linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Metabolic disorders**: USP19's regulation of protein metabolism may influence metabolic disorders, such as diabetes and obesity. 4. **Infectious diseases**: USP19's role in regulating protein stability and localization may impact the host's response to infection and the progression of diseases. In conclusion, USP19's complex roles in cellular regulation, protein metabolism, and response to environmental stressors underscore its importance as a critical component of the cellular machinery. Further research into USP19's functions and dysregulation may provide valuable insights into the pathogenesis of various diseases and the development of novel therapeutic strategies.

Genular Protein ID: 4056128782

Symbol: UBP19_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 19

UniProtKB Accession Codes:

O94966 A5PKX8 A6H8U2 B4DGT3 B4DTZ0 E7EN22 E7ETS0 E9PEG8 Q3KQW4 Q641Q9 Q6NZY8 Q86XV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19465887

Title: The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.

PubMed ID: 19465887

DOI: 10.1038/embor.2009.69

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21849505

Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.

PubMed ID: 21849505

DOI: 10.1074/jbc.m111.282020

PubMed ID: 22689415

Title: Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.

PubMed ID: 22689415

DOI: 10.1002/cbic.201200261

PubMed ID: 22128162

Title: Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia.

PubMed ID: 22128162

DOI: 10.1074/jbc.m111.305615

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1318
  • Mass: 145651
  • Checksum: EA9F318D03304AA1
  • Sequence:
    • MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 
PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 
RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR 
KGSLLHLTLP KKVPMLTWPS LLVEADEQLC IPPLNSQTCL LGSEENLAPL AGEKAVPPGN 
DPVSPAMVRS RNPGKDDCAK EEMAVAADAA TLVDEPESMV NLAFVKNDSY EKGPDSVVVH 
VYVKEICRDT SRVLFREQDF TLIFQTRDGN FLRLHPGCGP HTTFRWQVKL RNLIEPEQCT 
FCFTASRIDI CLRKRQSQRW GGLEAPAARV GGAKVAVPTG PTPLDSTPPG GAPHPLTGQE 
EARAVEKDKS KARSEDTGLD SVATRTPMEH VTPKPETHLA SPKPTCMVPP MPHSPVSGDS 
VEEEEEEEKK VCLPGFTGLV NLGNTCFMNS VIQSLSNTRE LRDFFHDRSF EAEINYNNPL 
GTGGRLAIGF AVLLRALWKG THHAFQPSKL KAIVASKASQ FTGYAQHDAQ EFMAFLLDGL 
HEDLNRIQNK PYTETVDSDG RPDEVVAEEA WQRHKMRNDS FIVDLFQGQY KSKLVCPVCA 
KVSITFDPFL YLPVPLPQKQ KVLPVFYFAR EPHSKPIKFL VSVSKENSTA SEVLDSLSQS 
VHVKPENLRL AEVIKNRFHR VFLPSHSLDT VSPSDTLLCF ELLSSELAKE RVVVLEVQQR 
PQVPSVPISK CAACQRKQQS EDEKLKRCTR CYRVGYCNQL CQKTHWPDHK GLCRPENIGY 
PFLVSVPASR LTYARLAQLL EGYARYSVSV FQPPFQPGRM ALESQSPGCT TLLSTGSLEA 
GDSERDPIQP PELQLVTPMA EGDTGLPRVW AAPDRGPVPS TSGISSEMLA SGPIEVGSLP 
AGERVSRPEA AVPGYQHPSE AMNAHTPQFF IYKIDSSNRE QRLEDKGDTP LELGDDCSLA 
LVWRNNERLQ EFVLVASKEL ECAEDPGSAG EAARAGHFTL DQCLNLFTRP EVLAPEEAWY 
CPQCKQHREA SKQLLLWRLP NVLIVQLKRF SFRSFIWRDK INDLVEFPVR NLDLSKFCIG 
QKEEQLPSYD LYAVINHYGG MIGGHYTACA RLPNDRSSQR SDVGWRLFDD STVTTVDESQ 
VVTRYAYVLF YRRRNSPVER PPRAGHSEHH PDLGPAAEAA ASQASRIWQE LEAEEEPVPE 
GSGPLGPWGP QDWVGPLPRG PTTPDEGCLR YFVLGTVAAL VALVLNVFYP LVSQSRWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.