Details for: HCST

Gene ID: 10870

Symbol: HCST

Ensembl ID: ENSG00000126264

Description: hematopoietic cell signal transducer

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.59
    Marker Score: 4,472
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.76
    Marker Score: 47,144
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.69
    Marker Score: 14,791
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.65
    Marker Score: 13,584
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.32
    Marker Score: 11,940
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.32
    Marker Score: 4,799
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.11
    Marker Score: 11,525
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.09
    Marker Score: 6,025
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.97
    Marker Score: 2,877
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.95
    Marker Score: 3,817
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.62
    Marker Score: 3,047
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.61
    Marker Score: 201,879
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.58
    Marker Score: 1,164
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.4
    Marker Score: 39,536
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.39
    Marker Score: 1,871
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.38
    Marker Score: 1,980
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.29
    Marker Score: 1,692
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.26
    Marker Score: 1,405
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.23
    Marker Score: 2,876
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.22
    Marker Score: 3,218
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.16
    Marker Score: 1,357
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.13
    Marker Score: 1,564
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.12
    Marker Score: 164,977
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.12
    Marker Score: 13,361
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.1
    Marker Score: 778
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.08
    Marker Score: 5,994
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.07
    Marker Score: 1,586
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.06
    Marker Score: 4,225
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.05
    Marker Score: 1,006
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.05
    Marker Score: 1,320
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.96
    Marker Score: 7,365
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.89
    Marker Score: 2,706
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.86
    Marker Score: 5,598
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.84
    Marker Score: 1,633
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.82
    Marker Score: 1,734
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.81
    Marker Score: 1,807
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.79
    Marker Score: 3,194
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.78
    Marker Score: 863
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.73
    Marker Score: 692
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.65
    Marker Score: 16,964
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.65
    Marker Score: 817
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.58
    Marker Score: 4,432
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.55
    Marker Score: 891
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.42
    Marker Score: 9,885
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.31
    Marker Score: 3,267
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.27
    Marker Score: 2,452
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.26
    Marker Score: 1,657
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.19
    Marker Score: 1,205
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.14
    Marker Score: 3,830
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.14
    Marker Score: 567
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.1
    Marker Score: 53,876
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.04
    Marker Score: 8,471
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2
    Marker Score: 5,190
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.97
    Marker Score: 4,444
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.96
    Marker Score: 595
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.93
    Marker Score: 438
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.92
    Marker Score: 19,452
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.9
    Marker Score: 930
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.89
    Marker Score: 3,079
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.89
    Marker Score: 4,563
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.88
    Marker Score: 1,478
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.86
    Marker Score: 2,053
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.82
    Marker Score: 1,221
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.81
    Marker Score: 1,319
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.8
    Marker Score: 2,172
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.8
    Marker Score: 734
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.79
    Marker Score: 2,315
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.73
    Marker Score: 1,471
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.65
    Marker Score: 1,126
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.65
    Marker Score: 9,996
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.64
    Marker Score: 1,361
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.59
    Marker Score: 1,205
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.59
    Marker Score: 1,198
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.57
    Marker Score: 656
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.57
    Marker Score: 1,386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.57
    Marker Score: 655
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.55
    Marker Score: 2,826
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1,492
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.49
    Marker Score: 2,599
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.45
    Marker Score: 1,480
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.45
    Marker Score: 718
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.37
    Marker Score: 652
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.34
    Marker Score: 463
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.33
    Marker Score: 964
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.33
    Marker Score: 917
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.32
    Marker Score: 1,758
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.31
    Marker Score: 1,426
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.3
    Marker Score: 636
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.29
    Marker Score: 721
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.29
    Marker Score: 859
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.29
    Marker Score: 1,434
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.29
    Marker Score: 773
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.26
    Marker Score: 663
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.25
    Marker Score: 276
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.25
    Marker Score: 791
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.23
    Marker Score: 441
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.22
    Marker Score: 1,068
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.2
    Marker Score: 337
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.2
    Marker Score: 926
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.14
    Marker Score: 827

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HCST is a non-coding gene, meaning it does not encode a protein sequence. Instead, it is involved in the regulation of protein function through post-transcriptional mechanisms, such as RNA splicing and microRNA binding. HCST has been identified as a key regulator of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway, which is essential for cell survival, proliferation, and differentiation. HCST is specifically expressed in various immune cells, including early promyelocytes, mature T cells, and natural killer cells. The presence of HCST in these cells suggests that it plays a crucial role in the development and function of these immune cells. **Pathways and Functions** HCST is involved in several key signaling pathways, including: 1. **PI3K/PKB signaling pathway**: HCST regulates the activity of PI3K and PKB, which are essential for cell survival, proliferation, and differentiation. 2. **Protein binding**: HCST interacts with various proteins, including signaling molecules and transcription factors, to regulate their activity. 3. **Protein phosphorylation**: HCST regulates the phosphorylation of proteins, which is a key mechanism for signal transduction. 4. **Regulation of immune response**: HCST plays a crucial role in the regulation of immune responses, including the activation and proliferation of immune cells. **Clinical Significance** The HCST gene has been implicated in several diseases, including: 1. **Immunodeficiency disorders**: Variants of the HCST gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune diseases**: HCST has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of immune responses contributes to disease pathogenesis. 3. **Cancer**: HCST has been identified as a potential oncogene, as its dysregulation can contribute to cancer development and progression. In conclusion, the HCST gene plays a critical role in the regulation of immune responses and is involved in several key signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function of HCST in the immune system. Further research is necessary to fully elucidate the role of HCST in human health and disease.

Genular Protein ID: 1662083828

Symbol: HCST_HUMAN

Name: Hematopoietic cell signal transducer

UniProtKB Accession Codes:

Q9UBK5 Q9UBS1 Q9Y3Y0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10528161

Title: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.

PubMed ID: 10528161

PubMed ID: 10426994

Title: An activating immunoreceptor complex formed by NKG2D and DAP10.

PubMed ID: 10426994

DOI: 10.1126/science.285.5428.730

PubMed ID: 11398969

Title: Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D.

PubMed ID: 11398969

DOI: 10.1007/s002510100321

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11015446

Title: DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.

PubMed ID: 11015446

DOI: 10.1084/jem.192.7.1059

PubMed ID: 11777960

Title: UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.

PubMed ID: 11777960

DOI: 10.4049/jimmunol.168.2.671

PubMed ID: 12740575

Title: NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.

PubMed ID: 12740575

DOI: 10.1038/ni929

PubMed ID: 12740576

Title: NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

PubMed ID: 12740576

DOI: 10.1038/ni930

PubMed ID: 15294961

Title: A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.

PubMed ID: 15294961

DOI: 10.4049/jimmunol.173.4.2470

PubMed ID: 16002667

Title: Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.

PubMed ID: 16002667

DOI: 10.4049/jimmunol.175.2.720

PubMed ID: 16339517

Title: Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.

PubMed ID: 16339517

DOI: 10.4049/jimmunol.175.12.7819

PubMed ID: 15894612

Title: The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

PubMed ID: 15894612

DOI: 10.1073/pnas.0502439102

PubMed ID: 16424177

Title: IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells.

PubMed ID: 16424177

DOI: 10.4049/jimmunol.176.3.1490

PubMed ID: 16582911

Title: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.

PubMed ID: 16582911

DOI: 10.1038/ni1325

PubMed ID: 18097042

Title: Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors.

PubMed ID: 18097042

DOI: 10.4049/jimmunol.180.1.409

PubMed ID: 26221034

Title: Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.

PubMed ID: 26221034

DOI: 10.1074/jbc.m115.643361

Sequence Information:

  • Length: 93
  • Mass: 9489
  • Checksum: 97786F24F8A2EE44
  • Sequence:
    • MIHLGHILFL LLLPVAAAQT TPGERSSLPA FYPGTSGSCS GCGSLSLPLL AGLVAADAVA 
SLLIVGAVFL CARPRRSPAQ EDGKVYINMP GRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.