Details for: CD300C

Gene ID: 10871

Symbol: CD300C

Ensembl ID: ENSG00000167850

Description: CD300c molecule

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.52
    Marker Score: 2,960
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.44
    Marker Score: 1,733
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.43
    Marker Score: 1,455
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2,363
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,552
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.11
    Marker Score: 61,835
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.06
    Marker Score: 2,648
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,466
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 671
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.79
    Marker Score: 2,174
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.76
    Marker Score: 8,858
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.75
    Marker Score: 1,818
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.74
    Marker Score: 18,984
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.62
    Marker Score: 309
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.59
    Marker Score: 327
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.54
    Marker Score: 351
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.54
    Marker Score: 1,406
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.54
    Marker Score: 618
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.5
    Marker Score: 3,046
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.47
    Marker Score: 1,967
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 463
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.45
    Marker Score: 183
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 831
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.37
    Marker Score: 246
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.36
    Marker Score: 397
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 377
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.33
    Marker Score: 200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4,760
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.29
    Marker Score: 284
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.29
    Marker Score: 72
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.29
    Marker Score: 197
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.27
    Marker Score: 354
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.26
    Marker Score: 215
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 106
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.25
    Marker Score: 401
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.25
    Marker Score: 449
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.22
    Marker Score: 223
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.2
    Marker Score: 609
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.2
    Marker Score: 101
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.19
    Marker Score: 249
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 202
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.15
    Marker Score: 93
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.14
    Marker Score: 88
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 277
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 193
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 95
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 231
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 40

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Signaling Receptor**: CD300C is a transmembrane receptor that spans the cell membrane, allowing it to interact with extracellular ligands and initiate intracellular signaling cascades. 2. **Immunoregulatory Function**: CD300C has been identified as a key player in regulating immune responses, particularly in the context of adaptive immunity, where it modulates T cell activation and cytokine production. 3. **Expression on Immune Cells**: CD300C is expressed on various immune cells, including monocytes, dendritic cells, and immature innate lymphoid cells, indicating its widespread involvement in immune regulation. 4. **Evolutionary Conservation**: The CD300C gene is highly conserved across species, suggesting its fundamental role in immune function and evolution. **Pathways and Functions:** CD300C is involved in multiple signaling pathways that regulate immune responses, including: 1. **Adaptive Immune Response**: CD300C modulates T cell activation, cytokine production, and immune cell differentiation, thereby influencing the adaptive immune response. 2. **Innate Immune Response**: CD300C interacts with pattern recognition receptors, such as Toll-like receptors, to regulate the innate immune response and modulate the activation of immune cells. 3. **Immunoregulatory Interactions**: CD300C interacts with non-immune cells, such as goblet cells and radial glial cells, to regulate immune responses and maintain tissue homeostasis. 4. **Neuroimmunological Interactions**: CD300C has been implicated in neuroimmunological interactions, where it modulates the activation of immune cells in the central nervous system. **Clinical Significance:** CD300C's involvement in immune regulation and its expression on various immune cells make it an attractive target for immunotherapeutic interventions. Dysregulation of CD300C has been implicated in various diseases, including: 1. **Autoimmune Diseases**: CD300C's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: CD300C's interaction with immune cells and its expression on tumor cells suggest its potential role in cancer immunotherapy. 3. **Neurological Disorders**: CD300C's involvement in neuroimmunological interactions makes it a potential target for the treatment of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, CD300C is a complex transmembrane signaling receptor that plays a critical role in regulating immune responses and maintaining tissue homeostasis. Its dysregulation has been implicated in various diseases, making it an attractive target for immunotherapeutic interventions. Further research is needed to fully elucidate the mechanisms of CD300C and its clinical significance.

Genular Protein ID: 62566367

Symbol: CLM6_HUMAN

Name: CMRF35-like molecule 6

UniProtKB Accession Codes:

Q08708

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1349532

Title: Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.

PubMed ID: 1349532

DOI: 10.1002/eji.1830220508

PubMed ID: 11556966

Title: The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family.

PubMed ID: 11556966

DOI: 10.1034/j.1399-0039.2001.057005415.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12483297

Title: Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility.

PubMed ID: 12483297

DOI: 10.1007/s00439-002-0851-y

Sequence Information:

  • Length: 224
  • Mass: 24830
  • Checksum: 60C88716D84600D2
  • Sequence:
    • MTARAWASWR SSALLLLLVP GYFPLSHPMT VAGPVGGSLS VQCRYEKEHR TLNKFWCRPP 
QILRCDKIVE TKGSAGKRNG RVSIRDSPAN LSFTVTLENL TEEDAGTYWC GVDTPWLRDF 
HDPIVEVEVS VFPAGTTTAS SPQSSMGTSG PPTKLPVHTW PSVTRKDSPE PSPHPGSLFS 
NVRFLLLVLL ELPLLLSMLG AVLWVNRPQR SSRSRQNWPK GENQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.