Details for: ME3

Gene ID: 10873

Symbol: ME3

Ensembl ID: ENSG00000151376

Description: malic enzyme 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.45
    Marker Score: 10,175
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.39
    Marker Score: 35,675
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85,215
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.3
    Marker Score: 87,503
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.17
    Marker Score: 43,153
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.15
    Marker Score: 8,319
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1
    Marker Score: 70,852
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.07
    Marker Score: 9,586
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.96
    Marker Score: 120,754
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.94
    Marker Score: 607
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.93
    Marker Score: 18,196
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.92
    Marker Score: 7,831
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,823
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,321
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17,817
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12,850
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.65
    Marker Score: 36,966
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.65
    Marker Score: 1,102
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.65
    Marker Score: 868
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,483
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.61
    Marker Score: 1,209
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.58
    Marker Score: 3,477
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.54
    Marker Score: 896
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.51
    Marker Score: 5,077
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.51
    Marker Score: 579
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.49
    Marker Score: 4,244
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.47
    Marker Score: 2,471
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.42
    Marker Score: 5,056
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.4
    Marker Score: 673
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2,830
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.33
    Marker Score: 1,430
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.32
    Marker Score: 7,939
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.32
    Marker Score: 1,014
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 19,982
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.27
    Marker Score: 761
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.26
    Marker Score: 26,991
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.18
    Marker Score: 660
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.16
    Marker Score: 2,236
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.12
    Marker Score: 6,034
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.07
    Marker Score: 857
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1,102
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.03
    Marker Score: 573
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,002
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.99
    Marker Score: 415
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 584
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2,231
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.92
    Marker Score: 455
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1,127
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.89
    Marker Score: 2,057
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,071
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.87
    Marker Score: 3,626
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.83
    Marker Score: 2,234
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.81
    Marker Score: 1,000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.81
    Marker Score: 3,387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.78
    Marker Score: 1,046
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.77
    Marker Score: 211
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.76
    Marker Score: 221
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.75
    Marker Score: 275
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.75
    Marker Score: 1,059
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.74
    Marker Score: 857
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.74
    Marker Score: 2,882
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.74
    Marker Score: 193
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.74
    Marker Score: 3,075
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.73
    Marker Score: 5,538
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.73
    Marker Score: 12,955
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 478
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 539
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.71
    Marker Score: 188
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.71
    Marker Score: 2,969
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 843
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.69
    Marker Score: 749
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.69
    Marker Score: 655
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.68
    Marker Score: 329
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.67
    Marker Score: 3,515
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.67
    Marker Score: 4,961
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.67
    Marker Score: 295
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.65
    Marker Score: 6,553
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.65
    Marker Score: 221
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.65
    Marker Score: 3,834
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.64
    Marker Score: 374

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ME3 is a mitochondrial enzyme, specifically localized within the mitochondrial matrix, where it participates in the conversion of malate to pyruvate. This reaction is crucial for the regeneration of NAD+ from NADP+, allowing for the continuation of glycolysis and subsequent energy production. ME3 is also known to interact with other enzymes and proteins involved in the TCA cycle, such as citrate synthase and isocitrate dehydrogenase. The enzyme's activity is tightly regulated by various post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions:** ME3 is involved in several key metabolic pathways, including: 1. **Citric Acid Cycle (TCA cycle):** ME3 participates in the TCA cycle by converting malate to pyruvate, generating energy for the cell. 2. **Aerobic Respiration:** ME3 is essential for the aerobic respiration process, allowing for the efficient conversion of glucose to ATP. 3. **Pyruvate Metabolism:** ME3 is involved in the regulation of pyruvate metabolism, including the conversion of pyruvate to acetyl-CoA. 4. **GABAergic Neurotransmission:** Recent studies have implicated ME3 in the regulation of GABAergic cortical interneurons, where it plays a crucial role in the modulation of inhibitory neurotransmission. **Clinical Significance:** Dysregulation of ME3 has been implicated in various neurological and metabolic disorders, including: 1. **Neurodegenerative Diseases:** ME3 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic Disorders:** ME3 is also involved in the regulation of glucose metabolism, and its dysfunction has been implicated in metabolic disorders, such as type 2 diabetes. 3. **Cancer:** ME3 has been shown to be overexpressed in certain types of cancer, including glioblastoma and ovarian cancer. 4. **Neurodevelopmental Disorders:** ME3 dysfunction has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, ME3 is a multifunctional enzyme that plays a crucial role in various metabolic pathways, including the TCA cycle, aerobic respiration, and pyruvate metabolism. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the importance of further research into the mechanisms of ME3 regulation and its potential therapeutic applications.

Genular Protein ID: 3402891587

Symbol: MAON_HUMAN

Name: Malic enzyme 3

UniProtKB Accession Codes:

Q16798 B7Z6V0 Q8TBJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 6 EMDB 3 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SABIO-RK 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7818469

Title: Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme.

PubMed ID: 7818469

DOI: 10.1042/bj3040687

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 604
  • Mass: 67068
  • Checksum: E0E79A75F3CAC524
  • Sequence:
    • MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG YDVTRNPHLN 
KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYERQ QSDLDKYIIL MTLQDRNEKL 
FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI 
KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD 
PLYIGLKHQR VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 
FNDDIQGTAS VAVAGILAAL RITKNKLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGVPKA 
EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE EVVRLVKPTA IIGVAAIAGA 
FTEQILRDMA SFHERPIIFA LSNPTSKAEC TAEKCYRVTE GRGIFASGSP FKSVTLEDGK 
TFIPGQGNNA YVFPGVALGV IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST 
IRDVSLRIAI KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN 
VQTV

Genular Protein ID: 1835580252

Symbol: B2R995_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R995

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 604
  • Mass: 67114
  • Checksum: FCF7FAA95A4E6548
  • Sequence:
    • MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG YDVTRNPHLN 
KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYERQ QSDLDKYIIL MTLQDRNEKL 
FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI 
KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD 
PLYIGLKHQR VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 
FNDDIQGTAS VAVAGILAAL RITKNKLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGVPKA 
EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE EVVRLVKPTT IIGVAAIAGA 
FTEQILRDMA SFHERPIIFA LSNPTSNTEC TAEKCYRVTE GRGIFASGSP FKSVTLEDGK 
TFIPGQGNNA YVFPGVALGV IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST 
IRDVSLRIAI KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN 
VQTV

Genular Protein ID: 3174370228

Symbol: Q6TCH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6TCH8

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 259
  • Mass: 29787
  • Checksum: FFFF9505A9CCC506
  • Sequence:
    • MAFTLEERLQ LGIHGLIPPC FLSQDVQLLR IMRYYERQQS DLDKYIILMT LQDRNEKLFY 
RVLTSDVEKF MPIVYTPTVG LACQHYGLTF RRPRGLFITI HDKGHLATML NSWPEDNIKA 
VVVTDGERIL GLGDLGCYGM GIPVGKLALY TACGGVNPQQ CLPVLLDVGT NNEELLRDPL 
YIGLKHQRVH GKAYDDLLDE FMQAVTDKFG INCLIQFEDF ANANAFRLLN KYRNKYCMFN 
DDIQDDFSRG PKRSQLFFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.