Details for: NMU

Gene ID: 10874

Symbol: NMU

Ensembl ID: ENSG00000109255

Description: neuromedin U

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.11
    Marker Score: 5,426
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 2.96
    Marker Score: 2,931
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.43
    Marker Score: 18,947
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.2
    Marker Score: 18,923
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.89
    Marker Score: 2,722
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.44
    Marker Score: 979
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.37
    Marker Score: 1,434
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,812
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.11
    Marker Score: 320
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 646
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.01
    Marker Score: 20,030
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.94
    Marker Score: 636
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,220
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.84
    Marker Score: 270
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1,568
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.82
    Marker Score: 924
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.76
    Marker Score: 6,397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.68
    Marker Score: 1,864
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 823
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.56
    Marker Score: 589
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.55
    Marker Score: 502
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.54
    Marker Score: 3,437
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.52
    Marker Score: 578
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 948
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.46
    Marker Score: 229
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.46
    Marker Score: 381
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.45
    Marker Score: 1,738
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6,880
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 881
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 254
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 239
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.39
    Marker Score: 5,231
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.39
    Marker Score: 290
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 492
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 214
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.37
    Marker Score: 2,732
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1,529
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.34
    Marker Score: 144
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.32
    Marker Score: 216
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3
    Marker Score: 618
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.29
    Marker Score: 10,677
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 126
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.25
    Marker Score: 217
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.25
    Marker Score: 420
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.24
    Marker Score: 172
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.23
    Marker Score: 116
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.23
    Marker Score: 548
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.23
    Marker Score: 57
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 231
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 124
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.19
    Marker Score: 138
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.18
    Marker Score: 624
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.18
    Marker Score: 179
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.18
    Marker Score: 327
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.18
    Marker Score: 500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.17
    Marker Score: 514
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 512
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.16
    Marker Score: 1,060
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.16
    Marker Score: 76
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.16
    Marker Score: 39,153
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 62
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.16
    Marker Score: 390

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NMU is a 29-amino acid neuropeptide that belongs to the neuromedin family, which also includes neuromedin U-like peptides. NMU is a ligand for two types of receptors, Type 1 and Type 2 neuromedin U receptors, which are G protein-coupled receptors that activate specific signaling pathways. NMU has been shown to have a positive regulatory effect on smooth muscle contraction and synaptic transmission, and it has been implicated in the regulation of feeding behavior and energy homeostasis. **Pathways and Functions** NMU exerts its effects through two main signaling pathways: the G alpha (i) and G alpha (q) signaling pathways. The activation of NMU receptors triggers the activation of these G proteins, which in turn activate downstream effectors, including adenylyl cyclase and phospholipase C. This leads to the production of cAMP and IP3, which in turn regulate smooth muscle contraction, feeding behavior, and synaptic transmission. NMU has also been shown to regulate energy homeostasis by modulating the activity of pancreatic cells and adipocytes. **Clinical Significance** NMU has been implicated in several clinical conditions, including obesity and metabolic disorders. Overexpression of NMU has been observed in obese mice, and it has been shown to regulate feeding behavior and energy homeostasis. NMU has also been implicated in the pathogenesis of metabolic disorders, including type 2 diabetes and metabolic syndrome. Furthermore, NMU has been shown to have a positive regulatory effect on smooth muscle contraction, which could have implications for the treatment of conditions such as hypertension and atherosclerosis. In addition, NMU has been shown to have a role in the regulation of synaptic transmission and has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. Further studies are needed to fully understand the role of NMU in these conditions and to explore its potential as a therapeutic target. **Implications and Future Directions** The study of NMU has significant implications for our understanding of energy homeostasis, feeding behavior, and synaptic transmission. Further studies are needed to fully understand the mechanisms by which NMU regulates these processes and to explore its potential as a therapeutic target for the treatment of metabolic disorders and neurological conditions. Additionally, the development of specific inhibitors or agonists for NMU receptors could provide new therapeutic options for the treatment of these conditions. In conclusion, NMU is a neuropeptide that plays a crucial role in various physiological processes, including energy homeostasis, feeding behavior, and synaptic transmission. Further studies are needed to fully understand the mechanisms by which NMU regulates these processes and to explore its potential as a therapeutic target for the treatment of metabolic disorders and neurological conditions.

Genular Protein ID: 1362164359

Symbol: NMU_HUMAN

Name: Neuromedin-U

UniProtKB Accession Codes:

P48645

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7619205

Title: Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract.

PubMed ID: 7619205

DOI: 10.1677/jme.0.0140157

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 174
  • Mass: 19741
  • Checksum: 8ABD8138769FA815
  • Sequence:
    • MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD 
TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV 
SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI

Genular Protein ID: 191053386

Symbol: E9PDJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PDJ7

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 149
  • Mass: 16708
  • Checksum: C697FD4AADF1F1B5
  • Sequence:
    • MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD 
TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV 
EEFQSPFASQ SRGYFLFRPR NGRRSAGFI

Genular Protein ID: 1291256801

Symbol: A0A0B4J202_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J202

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 2 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 158
  • Mass: 18003
  • Checksum: 7ADE02A74AD44CB3
  • Sequence:
    • MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEASN 
ALEELCFMIM GMLPKPQEQD EKDNTKRFLF HYSKTQKLGK SNVVSSVVHP LLQLVPHLHE 
RRMKRFRVDE EFQSPFASQS RGYFLFRPRN GRRSAGFI

Genular Protein ID: 2610941492

Symbol: Q86WB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86WB6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 2

Sequence Information:

  • Length: 109
  • Mass: 12565
  • Checksum: E5D7FF17B24EE606
  • Sequence:
    • SILPQGLQPE QQLQLWNEID DTCSSFLSID SQPQASNALE ELCFMIMGML PKPQEQDEKD 
NTKRFLFHYS KTQKLGKSNV VEEFQSPFAS QSRGYFLFRP RNGRRSAGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.