Details for: FGL2

Gene ID: 10875

Symbol: FGL2

Ensembl ID: ENSG00000127951

Description: fibrinogen like 2

Associated with

  • Immune system
    (R-HSA-168256)
  • Innate immune system
    (R-HSA-168249)
  • Neutrophil degranulation
    (R-HSA-6798695)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular matrix structural constituent
    (GO:0005201)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibrinogen complex
    (GO:0005577)
  • Ficolin-1-rich granule lumen
    (GO:1904813)
  • Negative regulation of defense response to virus
    (GO:0050687)
  • Negative regulation of dendritic cell antigen processing and presentation
    (GO:0002605)
  • Negative regulation of macrophage antigen processing and presentation
    (GO:0002617)
  • Negative regulation of memory t cell differentiation
    (GO:0043381)
  • Protein binding
    (GO:0005515)
  • T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:0002291)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.25
    Marker Score: 6,333
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.24
    Marker Score: 181,368
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.79
    Marker Score: 6,736
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.63
    Marker Score: 6,645
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.51
    Marker Score: 2,871
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.4
    Marker Score: 5,979
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.08
    Marker Score: 2,080
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.98
    Marker Score: 2,019
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.85
    Marker Score: 21,509
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.85
    Marker Score: 4,786
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.69
    Marker Score: 2,037
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.67
    Marker Score: 6,934
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.56
    Marker Score: 1,077
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,243
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.39
    Marker Score: 599
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.33
    Marker Score: 3,564
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.29
    Marker Score: 2,616
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.26
    Marker Score: 1,784
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.25
    Marker Score: 1,255
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.12
    Marker Score: 283
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.08
    Marker Score: 1,198
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 245
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.98
    Marker Score: 994
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.96
    Marker Score: 350
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,228
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.91
    Marker Score: 1,179
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 359
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,927
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.89
    Marker Score: 459
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.87
    Marker Score: 434
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,265
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.81
    Marker Score: 336
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8
    Marker Score: 853
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8
    Marker Score: 530
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.78
    Marker Score: 233
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,240
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.76
    Marker Score: 262
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.75
    Marker Score: 337
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.75
    Marker Score: 305
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,195
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.72
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,002
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 618
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.71
    Marker Score: 1,865
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.71
    Marker Score: 195
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.7
    Marker Score: 483
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.69
    Marker Score: 950
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.67
    Marker Score: 421
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.66
    Marker Score: 1,200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.63
    Marker Score: 844
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.63
    Marker Score: 362
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.63
    Marker Score: 162
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.62
    Marker Score: 21,075
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.61
    Marker Score: 374
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.61
    Marker Score: 212
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.61
    Marker Score: 142
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1,145
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.6
    Marker Score: 3,643
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 360
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6
    Marker Score: 1,013
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.58
    Marker Score: 496
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.57
    Marker Score: 411
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.55
    Marker Score: 341
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.52
    Marker Score: 350
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.52
    Marker Score: 160
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.52
    Marker Score: 855
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 344
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.51
    Marker Score: 128
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.51
    Marker Score: 309
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.51
    Marker Score: 1,479
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.49
    Marker Score: 166
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.49
    Marker Score: 16,531
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.49
    Marker Score: 436
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.48
    Marker Score: 208
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.48
    Marker Score: 198
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.47
    Marker Score: 457
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 124
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.46
    Marker Score: 267
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.45
    Marker Score: 238
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.44
    Marker Score: 122
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.44
    Marker Score: 510
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.43
    Marker Score: 128
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.43
    Marker Score: 184

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FGL2 is a member of the fibrinogen-like protein family, which consists of three members: FGL1, FGL2, and FGL3. FGL2 is characterized by its ability to bind to fibrinogen, fibrin, and other proteins, and its extracellular domain contains a calcium-binding site. The protein is also known as fibroleukin due to its ability to induce leukocyte activation and proliferation. FGL2 is expressed in various tissues, including the liver, spleen, and lungs, and is involved in the regulation of immune responses, particularly in the context of innate immunity. **Pathways and Functions** FGL2 is involved in several biological pathways, including: 1. **Immune response**: FGL2 plays a crucial role in regulating immune responses, particularly in the context of innate immunity. It is involved in the activation and proliferation of leukocytes, including neutrophils, monocytes, and macrophages. 2. **Extracellular matrix regulation**: FGL2 is involved in the regulation of extracellular matrix homeostasis, particularly in the context of tissue repair and remodeling. 3. **Neutrophil degranulation**: FGL2 is involved in the regulation of neutrophil degranulation, which is a critical process in the immune response against pathogens. 4. **Negative regulation of defense response to virus**: FGL2 has been shown to have a negative regulatory effect on the defense response to viral infections, suggesting its potential role in modulating immune responses to viral pathogens. **Proteins and Signaling Molecules** FGL2 interacts with several proteins and signaling molecules, including: 1. **Fibrinogen**: FGL2 binds to fibrinogen, which is a key component of the coagulation cascade. 2. **Ficolin-1**: FGL2 interacts with ficolin-1, a pattern recognition receptor involved in the recognition of pathogens. 3. **T-cell receptor**: FGL2 interacts with the T-cell receptor, which is involved in the activation of T-cells. 4. **MHC molecules**: FGL2 interacts with MHC molecules, which are involved in the presentation of antigens to T-cells. **Significantly Expressed Cells** FGL2 is expressed in several cell types, including: 1. **CD14-positive monocytes**: FGL2 is expressed in CD14-positive monocytes, which are involved in the recognition of pathogens. 2. **CD16-positive monocytes**: FGL2 is expressed in CD16-positive monocytes, which are involved in the activation of immune responses. 3. **Dendritic cells**: FGL2 is expressed in dendritic cells, which are involved in the presentation of antigens to T-cells. 4. **Macrophages**: FGL2 is expressed in macrophages, which are involved in the clearance of pathogens and the regulation of immune responses. 5. **Kupffer cells**: FGL2 is expressed in Kupffer cells, which are involved in the clearance of pathogens and the regulation of immune responses. **Clinical Significance** FGL2 has been implicated in several pathological conditions, including: 1. **Autoimmune diseases**: FGL2 has been shown to play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: FGL2 has been shown to be overexpressed in several types of cancer, including breast and lung cancer. 3. **Infectious diseases**: FGL2 has been shown to play a role in the pathogenesis of infectious diseases, such as tuberculosis and HIV. In conclusion, FGL2 is a multifunctional protein involved in the regulation of immune responses, extracellular matrix homeostasis, and the pathogenesis of several pathological conditions. Further research is needed to fully understand the role of FGL2 in human health and disease.

Genular Protein ID: 2872522357

Symbol: FGL2_HUMAN

Name: Fibroleukin

UniProtKB Accession Codes:

Q14314

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7642106

Title: Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein.

PubMed ID: 7642106

DOI: 10.1016/0378-1119(95)00240-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647217

Title: Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes.

PubMed ID: 9647217

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 439
  • Mass: 50229
  • Checksum: DF34656288E49E68
  • Sequence:
    • MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE EAGECPYQVS 
LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK LQADDNGDPG RNGLLLPSTG 
APGEVGDNRV RELESEVNKL SSELKNAKEE INVLHGRLEK LNLVNMNNIE NYVDSKVANL 
TFVVNSLDGK CSKCPSQEQI QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV 
YCDMETMGGG WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL 
RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN HDLKFFTTPD 
KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG VRNGIFWGTW PGVSEAHPGG 
YKSSFKEAKM MIRPKHFKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.