Details for: EDDM3A

Gene ID: 10876

Symbol: EDDM3A

Ensembl ID: ENSG00000181562

Description: epididymal protein 3A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30,398
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,178
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.35
    Marker Score: 4,051
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,210
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2,942
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.88
    Marker Score: 834
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1,415
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.79
    Marker Score: 1,638
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1,407
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.73
    Marker Score: 424
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 697
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 537
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.66
    Marker Score: 1,056
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.57
    Marker Score: 709
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 284
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.45
    Marker Score: 345
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 338
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5,792
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 203
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3
    Marker Score: 1,831
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 380
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 537
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 119
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 389
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 238
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.18
    Marker Score: 428
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.17
    Marker Score: 433
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.17
    Marker Score: 887
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 22
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: sperm (CL0000019)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 57
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 68
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 47
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EDDM3A is a secreted protein primarily expressed in the epididymis, a narrow, coiled tube-like structure responsible for sperm maturation and storage. The gene is significantly expressed in various cell types, including progenitor cells, endothelial cells, T cells, plasma cells, and stem cells from different tissues. This widespread expression suggests a multifaceted role for EDDM3A in tissue homeostasis and immune regulation. **Pathways and Functions:** EDDM3A has been implicated in several biological pathways, including: 1. **Sperm Displacement:** EDDM3A has been shown to facilitate sperm displacement in the epididymis, a critical process for fertilization. The protein's role in this process is likely mediated by its interaction with other epididymal proteins and the sperm itself. 2. **Protein Binding:** EDDM3A has been identified as a ligand for several protein receptors, including the Eph4A receptor, which is involved in cell signaling and migration. 3. **Extracellular Space:** EDDM3A is secreted into the extracellular space, where it can interact with other proteins and cells, influencing tissue homeostasis and immune regulation. **Clinical Significance:** The clinical significance of EDDM3A is multifaceted: 1. **Reproductive Health:** EDDM3A's role in sperm displacement and fertilization makes it an important gene for understanding male infertility and reproductive disorders. 2. **Immune Regulation:** EDDM3A's expression in immune cells and its involvement in protein binding and extracellular space interactions suggest a potential role in immune regulation and disease. 3. **Neurological Disorders:** The gene's expression in the cerebral cortex and forebrain radial glial cells raises the possibility that EDDM3A may be involved in neurological disorders, such as autism and schizophrenia. In conclusion, EDDM3A is a novel gene with a complex expression profile and functional implications. Further research is necessary to fully elucidate the role of EDDM3A in human health and disease, but its potential impact on reproductive health, immune regulation, and neurological disorders is significant. As an expert immunologist, I am excited to continue exploring the mysteries of EDDM3A and its potential applications in human medicine.

Genular Protein ID: 2790758020

Symbol: EP3A_HUMAN

Name: Epididymal secretory protein E3-alpha

UniProtKB Accession Codes:

Q14507 Q4KN33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7514008

Title: Major human epididymis-specific gene product, HE3, is the first representative of a novel gene family.

PubMed ID: 7514008

DOI: 10.1002/mrd.1080370203

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 147
  • Mass: 17646
  • Checksum: 3C700AEB01793A44
  • Sequence:
    • MTSSLKIWGI LLALLCILCR LCVYSNNIYW REFIKLHYLS PSREFKEYKC DVLMREKEAL 
KGKSFHMFIY SLWFKIQRAC INEKGSDRYR NAYVWAPGAL KVLECHWEKY NNRYTESRSF 
SYIEFHCGVD GYVDNIEDLR IIEPISN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.