Details for: CFHR4

Gene ID: 10877

Symbol: CFHR4

Ensembl ID: ENSG00000134365

Description: complement factor H related 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.69
    Marker Score: 30,228
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.35
    Marker Score: 1,905
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.23
    Marker Score: 3,851
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2,166
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.92
    Marker Score: 2,141
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.91
    Marker Score: 1,056
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.23
    Marker Score: 1,167
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.05
    Marker Score: 1,455
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,712
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,937
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,333
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.92
    Marker Score: 539
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.85
    Marker Score: 450
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1,431
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1,168
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.69
    Marker Score: 735
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.67
    Marker Score: 1,224
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.66
    Marker Score: 639
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 523
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.62
    Marker Score: 135
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1,235
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.57
    Marker Score: 392
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.55
    Marker Score: 1,140
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.5
    Marker Score: 136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.47
    Marker Score: 120
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.44
    Marker Score: 128
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.44
    Marker Score: 137
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.44
    Marker Score: 133
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.44
    Marker Score: 541
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.44
    Marker Score: 1,427
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.43
    Marker Score: 138
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 380
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4
    Marker Score: 136
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.38
    Marker Score: 138
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.33
    Marker Score: 390
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5,183
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 117
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1,847
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 183
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.24
    Marker Score: 122
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.24
    Marker Score: 630
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 123
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.22
    Marker Score: 134
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 124
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 103
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.19
    Marker Score: 209
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 123
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 140
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.18
    Marker Score: 137
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.16
    Marker Score: 134
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.15
    Marker Score: 137
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 354
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 438
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.14
    Marker Score: 138
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.13
    Marker Score: 243
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 540
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 136
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.12
    Marker Score: 138
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.12
    Marker Score: 1,112
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.11
    Marker Score: 137
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.11
    Marker Score: 138
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.11
    Marker Score: 128
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 137
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1
    Marker Score: 138
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 132
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.09
    Marker Score: 137

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CFHR4 shares a high degree of sequence similarity with complement factor H (CFH), another member of the CFH family. This similarity suggests that CFHR4 may have a similar function in regulating the complement system. Notably, CFHR4 has a unique structure, with a characteristic complement receptor 1 (CR1) domain, which allows it to bind to complement components C3b and C4b. This binding ability is thought to modulate the complement cascade, preventing excessive activation and tissue damage. **Pathways and Functions** CFHR4 is involved in several key pathways, including: 1. **Complement activation**: CFHR4 regulates the activation of the complement system by binding to complement components C3b and C4b, thereby modulating the complement cascade. 2. **Regulation of complement cascade**: CFHR4 helps to prevent excessive activation of the complement system, which can lead to tissue damage and autoimmune disorders. 3. **Immune system regulation**: CFHR4 is expressed on the surface of immune cells, including B cells and endothelial cells, suggesting its involvement in immune cell interactions and regulation. 4. **Lipid transport**: CFHR4 has been implicated in lipid transport and metabolism, although the exact mechanisms are not yet fully understood. **Clinical Significance** Dysregulation of CFHR4 has been implicated in several autoimmune and inflammatory disorders, including: 1. **Systemic lupus erythematosus (SLE)**: CFHR4 has been associated with SLE, a chronic autoimmune disease characterized by inflammation and tissue damage. 2. **Complement-mediated glomerulonephritis**: CFHR4 has been implicated in the development of complement-mediated glomerulonephritis, a kidney disease characterized by inflammation and tissue damage. 3. **Autoimmune hemolytic anemia**: CFHR4 has been associated with autoimmune hemolytic anemia, a condition characterized by the destruction of red blood cells. In conclusion, CFHR4 is an important regulator of the complement system, and its dysregulation has significant implications for autoimmune and inflammatory disorders. Further research is needed to fully understand the function and clinical significance of CFHR4.

Genular Protein ID: 2150201206

Symbol: FHR4_HUMAN

Name: Complement factor H-related protein 4

UniProtKB Accession Codes:

Q92496 A8K9N7 B1ALQ9 C9J7J7 Q5DVJ7 Q9UJY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9038172

Title: The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins.

PubMed ID: 9038172

DOI: 10.1074/jbc.272.9.5627

PubMed ID: 15562282

Title: FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.

PubMed ID: 15562282

DOI: 10.1038/sj.ejhg.5201324

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9476126

Title: Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4).

PubMed ID: 9476126

DOI: 10.1016/s0162-3109(97)00075-1

Sequence Information:

  • Length: 578
  • Mass: 65351
  • Checksum: CB80749443932B3F
  • Sequence:
    • MLLLINVILT LWVSCANGQE VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ SYSYYCDQNF 
VTPSGSYWDY IHCTQDGWSP TVPCLRTCSK SDVEIENGFI SESSSIYILN EETQYNCKPG 
YATAEGNSSG SITCLQNGWS TQPICIKFCD MPVFENSRAK SNGMWFKLHD TLDYECYDGY 
ESSYGNTTDS IVCGEDGWSH LPTCYNSSEN CGPPPPISNG DTTSFPQKVY LPWSRVEYQC 
QSYYELQGSK YVTCSNGDWS EPPRCISMKP CEFPEIQHGH LYYENTRRPY FPVATGQSYS 
YYCDQNFVTP SGSYWDYIHC TQDGWLPTVP CLRTCSKSDI EIENGFISES SSIYILNKEI 
QYKCKPGYAT ADGNSSGSIT CLQNGWSAQP ICIKFCDMPV FENSRAKSNG MRFKLHDTLD 
YECYDGYEIS YGNTTGSIVC GEDGWSHFPT CYNSSEKCGP PPPISNGDTT SFLLKVYVPQ 
SRVEYQCQSY YELQGSNYVT CSNGEWSEPP RCIHPCIITE ENMNKNNIQL KGKSDIKYYA 
KTGDTIEFMC KLGYNANTSV LSFQAVCREG IVEYPRCE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.