Details for: SMR3B

Gene ID: 10879

Symbol: SMR3B

Ensembl ID: ENSG00000171201

Description: submaxillary gland androgen regulated protein 3B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.52
    Marker Score: 8,030
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,176
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.91
    Marker Score: 2,136
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.28
    Marker Score: 600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.15
    Marker Score: 1,863
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1,425
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1,162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 106
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.48
    Marker Score: 659
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 106
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.4
    Marker Score: 159
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.25
    Marker Score: 225
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.25
    Marker Score: 130
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.24
    Marker Score: 135
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.21
    Marker Score: 405
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 383
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 365
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 175
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.15
    Marker Score: 205
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 104
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 169
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1
    Marker Score: 1,505
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 585
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 919
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.05
    Marker Score: 199
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 130
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: serous cell of epithelium of bronchus (CL1000331)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 82
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.03
    Marker Score: 67
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Androgen-regulated expression**: SMR3B is specifically expressed in the submaxillary gland, which is responsive to androgens. This suggests that SMR3B is a key player in androgen-mediated signaling pathways. 2. **Multifunctional protein**: SMR3B is involved in various cellular processes, including protein binding, regulation of sensory perception of pain, and inhibition of endopeptidase activity. 3. **Tissue-specific expression**: SMR3B is expressed in distinct cell types, including salivary gland acinar cells, endothelial cells, and immune cells, highlighting its importance in tissue homeostasis. 4. **Significant cellular localization**: SMR3B is localized to the extracellular space, where it can interact with other proteins and regulate cellular signaling. **Pathways and Functions:** 1. **Androgen signaling pathway**: SMR3B is involved in the regulation of androgen signaling, which is essential for maintaining tissue homeostasis, particularly in the submaxillary gland. 2. **Pain perception regulation**: SMR3B plays a role in regulating sensory perception of pain, highlighting its involvement in the complex regulation of pain signaling pathways. 3. **Endopeptidase inhibition**: SMR3B inhibits endopeptidase activity, which is essential for regulating the degradation of peptides and proteins involved in cellular signaling. 4. **Extracellular exosome regulation**: SMR3B is involved in the regulation of extracellular exosome function, which is crucial for maintaining cellular homeostasis and regulating tissue function. **Clinical Significance:** 1. **Androgen-related disorders**: SMR3B's involvement in androgen signaling pathways makes it a potential target for the treatment of androgen-related disorders, such as prostate cancer and hypogonadism. 2. **Pain management**: SMR3B's role in regulating pain perception highlights its potential as a therapeutic target for the management of chronic pain disorders. 3. **Immune system dysregulation**: SMR3B's expression in immune cells suggests its involvement in immune system dysregulation, making it a potential target for the treatment of autoimmune disorders. 4. **Salivary gland disorders**: SMR3B's expression in salivary gland cells highlights its potential role in the pathogenesis of salivary gland disorders, such as xerostomia. In conclusion, SMR3B is a multifunctional gene that plays a critical role in regulating androgen signaling, pain perception, and cellular homeostasis. Its involvement in various cellular processes and tissue-specific expression highlight its importance in maintaining tissue function and regulating cellular homeostasis. Further studies are necessary to fully elucidate the functions and clinical significance of SMR3B.

Genular Protein ID: 3961248907

Symbol: SMR3B_HUMAN

Name: Submaxillary gland androgen-regulated protein 3B

UniProtKB Accession Codes:

P02814 B7ZMG7 Q9UBN0 Q9UCT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7982889

Title: Molecular cloning and sequence analysis of cDNA coding for the precursor of the human salivary proline-rich peptide P-B.

PubMed ID: 7982889

DOI: 10.1093/oxfordjournals.jbchem.a124464

PubMed ID: 10731710

Title: Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-B.

PubMed ID: 10731710

DOI: 10.1093/oxfordjournals.jbchem.a022620

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 479131

Title: Isolation and amino acid sequences of proline-rich peptides of human whole saliva.

PubMed ID: 479131

PubMed ID: 1747107

Title: Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva.

PubMed ID: 1747107

DOI: 10.1042/bj2800341

Sequence Information:

  • Length: 79
  • Mass: 8188
  • Checksum: 7B10AE90E95BCB61
  • Sequence:
    • MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPQP FGPGFVPPPP PPPYGPGRIP 
PPPPAPYGPG IFPPPPPQP

Genular Protein ID: 90655616

Symbol: Q504X8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q504X8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 106
  • Mass: 12006
  • Checksum: 949E2AF705AEB847
  • Sequence:
    • MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPQP FGPGFVPPPP PPPYGPGRIP 
PPYSCTPNMN NCSRCHHHHK RHHYPCNYCF CYPKYEFQHC FQETFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.