Details for: CEACAM8

Gene ID: 1088

Symbol: CEACAM8

Ensembl ID: ENSG00000124469

Description: CEA cell adhesion molecule 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6814
    Cell Significance Index: -3.6800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.4189
    Cell Significance Index: 20.6000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3566
    Cell Significance Index: 2.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3307
    Cell Significance Index: 11.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3232
    Cell Significance Index: 8.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1767
    Cell Significance Index: 2.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1518
    Cell Significance Index: 4.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1080
    Cell Significance Index: 6.6200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0919
    Cell Significance Index: 0.4000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0700
    Cell Significance Index: 0.8900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0389
    Cell Significance Index: 0.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0364
    Cell Significance Index: 25.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0354
    Cell Significance Index: 0.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0261
    Cell Significance Index: 23.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0164
    Cell Significance Index: 1.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0040
    Cell Significance Index: 0.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5600
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0027
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0051
    Cell Significance Index: -1.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0084
    Cell Significance Index: -1.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0099
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0103
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0113
    Cell Significance Index: -1.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0128
    Cell Significance Index: -1.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0143
    Cell Significance Index: -1.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0152
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0169
    Cell Significance Index: -1.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0175
    Cell Significance Index: -0.7600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0178
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0182
    Cell Significance Index: -1.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0190
    Cell Significance Index: -0.8600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0214
    Cell Significance Index: -0.2300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0233
    Cell Significance Index: -0.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0237
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0253
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0257
    Cell Significance Index: -0.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0267
    Cell Significance Index: -0.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0283
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0284
    Cell Significance Index: -1.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0292
    Cell Significance Index: -0.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0294
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0294
    Cell Significance Index: -1.3000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0320
    Cell Significance Index: -1.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0368
    Cell Significance Index: -1.9100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0369
    Cell Significance Index: -0.4100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.0386
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0389
    Cell Significance Index: -1.8300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0390
    Cell Significance Index: -0.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0412
    Cell Significance Index: -0.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0416
    Cell Significance Index: -1.0600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0420
    Cell Significance Index: -0.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0427
    Cell Significance Index: -1.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0471
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0476
    Cell Significance Index: -0.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0482
    Cell Significance Index: -1.4200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0548
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0551
    Cell Significance Index: -0.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0555
    Cell Significance Index: -0.7000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0556
    Cell Significance Index: -0.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0556
    Cell Significance Index: -0.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0580
    Cell Significance Index: -1.2300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0580
    Cell Significance Index: -0.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0591
    Cell Significance Index: -1.8700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0592
    Cell Significance Index: -1.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0609
    Cell Significance Index: -1.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0620
    Cell Significance Index: -1.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0630
    Cell Significance Index: -1.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0643
    Cell Significance Index: -1.6900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0653
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0663
    Cell Significance Index: -1.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0666
    Cell Significance Index: -1.9000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0682
    Cell Significance Index: -1.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0682
    Cell Significance Index: -1.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0692
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0710
    Cell Significance Index: -2.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0711
    Cell Significance Index: -1.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0712
    Cell Significance Index: -1.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0714
    Cell Significance Index: -1.7800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0721
    Cell Significance Index: -0.7700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0727
    Cell Significance Index: -0.9700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0755
    Cell Significance Index: -0.8900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0779
    Cell Significance Index: -0.9400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0781
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Localization**: CEACAM8 is primarily expressed on the cell surface, where it interacts with other molecules to facilitate cell-cell adhesion, signaling, and immune response. 2. **Cell Adhesion**: CEACAM8 mediates heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, promoting the formation of cell aggregates and tissue organization. 3. **Immune Response**: CEACAM8 is involved in the regulation of immune cell functions, including neutrophil degranulation, immune system activation, and innate immune response. 4. **Granule Membrane Organization**: CEACAM8 is also localized to the granule membranes of neutrophils and other immune cells, where it regulates the release of antimicrobial peptides and other granule contents. 5. **Protein Interactions**: CEACAM8 interacts with various proteins, including fibronectin, to form protein complexes that regulate cell adhesion, migration, and signaling. **Pathways and Functions:** 1. **Heterophilic Cell-Cell Adhesion**: CEACAM8 mediates cell-cell adhesion through interactions with other cell surface molecules, promoting tissue organization and immune response. 2. **Immune Response Regulation**: CEACAM8 regulates immune cell functions, including neutrophil degranulation, immune system activation, and innate immune response. 3. **Granule Membrane Organization**: CEACAM8 regulates the organization and release of antimicrobial peptides and other granule contents from neutrophils and other immune cells. 4. **Cell Migration and Signaling**: CEACAM8 interacts with fibronectin to regulate cell migration, adhesion, and signaling pathways. 5. **Tissue Organization**: CEACAM8 is involved in the organization of the extracellular matrix and the formation of fibronectin matrix, which regulates tissue structure and function. **Clinical Significance:** 1. **Cancer Association**: CEACAM8 has been implicated in various cancers, including colorectal, lung, and breast cancer, where it is often overexpressed. 2. **Inflammatory Diseases**: CEACAM8 is involved in inflammatory diseases, including atherosclerosis, where it regulates immune cell functions and tissue organization. 3. **Neurological Disorders**: CEACAM8 has been implicated in neurological disorders, including Alzheimer's disease, where it is involved in the regulation of immune cell functions and tissue organization. 4. **Therapeutic Targeting**: CEACAM8 has emerged as a potential therapeutic target for various conditions, including cancer, inflammatory diseases, and neurological disorders. In conclusion, CEACAM8 is a multifunctional protein that plays a crucial role in various cellular processes, including immune response, cell adhesion, and granule membrane organization. Its significance in human health and disease has been increasingly recognized, and it has emerged as a potential therapeutic target for various conditions. Further research is needed to fully elucidate the functions and clinical significance of CEACAM8.

Genular Protein ID: 3010986785

Symbol: CEAM8_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 8

UniProtKB Accession Codes:

P31997 O60399 Q16574

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2208113

Title: Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.

PubMed ID: 2208113

PubMed ID: 2306228

Title: Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.

PubMed ID: 2306228

DOI: 10.1016/0006-291x(90)90975-s

PubMed ID: 1427854

Title: Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.

PubMed ID: 1427854

DOI: 10.1016/s0888-7543(05)80230-7

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427723

Title: Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.

PubMed ID: 9427723

PubMed ID: 8776764

Title: Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae.

PubMed ID: 8776764

DOI: 10.1006/prep.1996.0065

PubMed ID: 2022629

Title: A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.

PubMed ID: 2022629

DOI: 10.1016/s0021-9258(18)92930-3

PubMed ID: 11590190

Title: Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8.

PubMed ID: 11590190

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 26483485

Title: Diverse oligomeric states of CEACAM IgV domains.

PubMed ID: 26483485

DOI: 10.1073/pnas.1509511112

Sequence Information:

  • Length: 349
  • Mass: 38154
  • Checksum: AACF74DA1AC839D8
  • Sequence:
    • MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE VLLLVHNLPQ 
DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET IYPNASLLMR NVTRNDTGSY 
TLQVIKLNLM SEEVTGQFSV HPETPKPSIS SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV 
NGQSLPVSPR LQLSNGNRTL TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP 
TISPSDTYYH AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH 
TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALI

Genular Protein ID: 1374821798

Symbol: B4DLI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLI3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 256
  • Mass: 27850
  • Checksum: EEB359FD2275046F
  • Sequence:
    • MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE VLLLVHNLPQ 
DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET IYPNASLLMR SVTRNDVGPY 
ECEIQNPASA NFSDPVTLNV LYGPDAPTIS PSDTYYHAGV NLNLSCHAAS NPPSQYSWSV 
NGTFQQYTQK LFIPNITTKN SGSYACHTTN SATGRNRTTV RMITVSDALV QGSSPGLSAR 
ATVSIMIGVL ARVALI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.