Details for: CEACAM8

Gene ID: 1088

Symbol: CEACAM8

Ensembl ID: ENSG00000124469

Description: CEA cell adhesion molecule 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.91
    Marker Score: 1304
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.81
    Marker Score: 1212.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.07
    Marker Score: 2587
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1979
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.04
    Marker Score: 3024
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.93
    Marker Score: 2992
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.89
    Marker Score: 679.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.78
    Marker Score: 1076.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.77
    Marker Score: 2271
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.73
    Marker Score: 363
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1442
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.66
    Marker Score: 5596
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 476
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9069
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.56
    Marker Score: 327
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 290
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 411
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.38
    Marker Score: 367
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.37
    Marker Score: 417
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.36
    Marker Score: 122
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.35
    Marker Score: 128
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 333
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 86
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.3
    Marker Score: 148
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.25
    Marker Score: 704
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 453
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 211
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 566
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.17
    Marker Score: 87
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 148
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 127
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1
    Marker Score: 293
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 146
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.09
    Marker Score: 225
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.08
    Marker Score: 57.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.07
    Marker Score: 72.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.06
    Marker Score: 27.5

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Other Information

**Key characteristics:** * The CEACAM8 gene is located on chromosome 17q21.1. * It is a large gene encoding a protein of approximately 1300 amino acids. * The protein is a member of the cadherin superfamily of CAMs. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is involved in cell-cell adhesion, migration, and signaling. **Pathways and functions:** * The CEACAM8 gene is involved in cell-cell adhesion by binding to cadherins on the surface of neighboring cells. * It is also involved in cell migration and signaling by interacting with other CAMs and signaling molecules. * It is involved in the formation of the blood-brain barrier by binding to extracellular matrix proteins. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance:** * Mutations in the CEACAM8 gene have been linked to several human diseases, including lung cancer, colon cancer, and multiple sclerosis. * The CEACAM8 gene is a potential target for cancer immunotherapy. * Inhibition of CEACAM8 has been shown to inhibit cancer cell growth and migration. **Additional information:** * The CEACAM8 gene is also known as CD146 and E-cadherin. * It is a highly conserved protein with similar sequences in mammals. * It is a transmembrane protein that is expressed on the surface of cells. * It is a type of cell adhesion molecule that is involved in cell-cell adhesion, migration, and signaling.

Genular Protein ID: 3010986785

Symbol: CEAM8_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 8

UniProtKB Accession Codes:

P31997 O60399 Q16574

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2208113

Title: Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.

PubMed ID: 2208113

PubMed ID: 2306228

Title: Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.

PubMed ID: 2306228

DOI: 10.1016/0006-291x(90)90975-s

PubMed ID: 1427854

Title: Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.

PubMed ID: 1427854

DOI: 10.1016/s0888-7543(05)80230-7

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427723

Title: Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.

PubMed ID: 9427723

PubMed ID: 8776764

Title: Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae.

PubMed ID: 8776764

DOI: 10.1006/prep.1996.0065

PubMed ID: 2022629

Title: A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.

PubMed ID: 2022629

DOI: 10.1016/s0021-9258(18)92930-3

PubMed ID: 11590190

Title: Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8.

PubMed ID: 11590190

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 26483485

Title: Diverse oligomeric states of CEACAM IgV domains.

PubMed ID: 26483485

DOI: 10.1073/pnas.1509511112

Sequence Information:

  • Length: 349
  • Mass: 38154
  • Checksum: AACF74DA1AC839D8
  • Sequence:
    • MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE VLLLVHNLPQ 
DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET IYPNASLLMR NVTRNDTGSY 
TLQVIKLNLM SEEVTGQFSV HPETPKPSIS SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV 
NGQSLPVSPR LQLSNGNRTL TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP 
TISPSDTYYH AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH 
TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALI

Genular Protein ID: 1374821798

Symbol: B4DLI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLI3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 256
  • Mass: 27850
  • Checksum: EEB359FD2275046F
  • Sequence:
    • MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE VLLLVHNLPQ 
DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET IYPNASLLMR SVTRNDVGPY 
ECEIQNPASA NFSDPVTLNV LYGPDAPTIS PSDTYYHAGV NLNLSCHAAS NPPSQYSWSV 
NGTFQQYTQK LFIPNITTKN SGSYACHTTN SATGRNRTTV RMITVSDALV QGSSPGLSAR 
ATVSIMIGVL ARVALI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.