Details for: ACTL7B

Gene ID: 10880

Symbol: ACTL7B

Ensembl ID: ENSG00000148156

Description: actin like 7B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.93
    Marker Score: 3,285
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,851
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.58
    Marker Score: 1,464
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.53
    Marker Score: 4,367
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2,393
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.35
    Marker Score: 1,371
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,223
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.51
    Marker Score: 793
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1,218
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.09
    Marker Score: 454
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,064
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1,204
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1,764
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1,893
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12,413
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.76
    Marker Score: 1,201
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,203
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 548
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 387
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.56
    Marker Score: 248
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 205
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 241
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.19
    Marker Score: 1,194
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 745
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 176
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 50
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.02
    Marker Score: 84
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 118
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACTL7B is an actin-like protein, characterized by its ability to interact with actin filaments and modulate their dynamics. This protein is specifically expressed in various cell types, including erythrocytes, microglial cells, megakaryocytes, T cells, blood vessel endothelial cells, pericytes, plasma cells, hematopoietic stem cells, B cells, and goblet cells. Its expression is widespread, underscoring its potential role in maintaining cellular homeostasis. **Pathways and Functions:** ACTL7B is involved in several key pathways, including: 1. **Actin Cytoskeleton Organization:** ACTL7B interacts with actin filaments, regulating their dynamics and organization. This interaction is crucial for maintaining cellular shape, motility, and division. 2. **Cytoskeleton Organization:** ACTL7B contributes to the organization of the cytoskeleton, ensuring proper cell signaling, migration, and adhesion. 3. **Protein Binding:** ACTL7B interacts with various proteins, including actin-binding proteins, cytoskeletal regulators, and signaling molecules, modulating their activities. 4. **Structural Constituent of Cytoskeleton:** ACTL7B is a structural component of the cytoskeleton, providing mechanical support and stability to cells. **Clinical Significance:** The significance of ACTL7B lies in its potential role in various diseases, including: 1. **Immune-related Disorders:** Dysregulation of ACTL7B expression has been linked to immune-related disorders, such as autoimmune diseases and immunodeficiencies. 2. **Cancer:** ACTL7B may play a role in cancer progression, as its expression is altered in various types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders:** ACTL7B has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where actin cytoskeleton dysregulation is a hallmark. 4. **Vascular Diseases:** ACTL7B may contribute to vascular diseases, such as atherosclerosis, where actin cytoskeleton organization is critical for endothelial cell function. In conclusion, ACTL7B is a novel actin-like protein with significant implications in immune cell function, disease, and cellular homeostasis. Further research is needed to elucidate the molecular mechanisms underlying its functions and to explore its therapeutic potential in various diseases. **Recommendations:** 1. **Further Research:** Conduct in-depth studies to elucidate the molecular mechanisms underlying ACTL7B's functions and its role in disease. 2. **Functional Analysis:** Investigate the functional consequences of ACTL7B expression alterations in various cell types and disease models. 3. **Therapeutic Targeting:** Explore the potential of ACTL7B as a therapeutic target for immune-related disorders, cancer, and neurological diseases. By advancing our understanding of ACTL7B, we can uncover novel therapeutic strategies for a range of diseases, ultimately improving human health and well-being.

Genular Protein ID: 1217323928

Symbol: ACL7B_HUMAN

Name: Actin-like protein 7B

UniProtKB Accession Codes:

Q9Y614 B2R9Q2 Q5JSV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10373328

Title: Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31.

PubMed ID: 10373328

DOI: 10.1006/geno.1999.5848

PubMed ID: 17644991

Title: Single nucleotide polymorphisms: discovery of the genetic causes of male infertility.

PubMed ID: 17644991

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 415
  • Mass: 45234
  • Checksum: F29F29C2101F0D8E
  • Sequence:
    • MATRNSPMPL GTAQGDPGEA GTRPGPDASL RDTGAATQLK MKPRKVHKIK AVIIDLGSQY 
CKCGYAGEPR PTYFISSTVG KRCPEAADAG DTRKWTLVGH ELLNTEAPLK LVNPLKHGIV 
VDWDCVQDIW EYIFRTAMKI LPEEHAVLVS DPPLSPSSNR EKYAELMFET FGIPAMHVTS 
QSLLSIYSYG KTSGLVVESG HGVSHVVPIS EGDVLPGLTS RADYAGGDLT NYLMQLLNEA 
GHAFTDDHLH IIEHIKKKCC YAAFLPEEEL GLVPEELRVD YELPDGKLIT IGQERFRCSE 
MLFQPSLAGS TQPGLPELTA ACLGRCQDTG FKEEMAANVL LCGGCTMLDG FPERFQRELS 
LLCPGDSPAV AAAPERKTSV WTGGSILASL QAFQQLWVSK EEFEERGSVA IYSKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.