Details for: MRPS30

Gene ID: 10884

Symbol: MRPS30

Ensembl ID: ENSG00000112996

Description: mitochondrial ribosomal protein S30

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.47
    Marker Score: 3,096
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.38
    Marker Score: 936
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.21
    Marker Score: 1,267
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.2
    Marker Score: 820
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1,831
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.16
    Marker Score: 1,454
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.13
    Marker Score: 1,509
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.13
    Marker Score: 562
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.12
    Marker Score: 1,184
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9,577
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.11
    Marker Score: 1,118
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2,251
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.06
    Marker Score: 10,095
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.06
    Marker Score: 1,526
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.05
    Marker Score: 64,719
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2,436
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.02
    Marker Score: 1,089
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.01
    Marker Score: 609
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.01
    Marker Score: 4,135
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Marker Score: 3,947
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1,476
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,654
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.99
    Marker Score: 664
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.99
    Marker Score: 746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,876
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.99
    Marker Score: 3,838
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Marker Score: 476
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.98
    Marker Score: 344
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.98
    Marker Score: 1,732
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.96
    Marker Score: 11,103
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.94
    Marker Score: 4,066
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.94
    Marker Score: 302
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.94
    Marker Score: 518
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,390
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.94
    Marker Score: 220
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.93
    Marker Score: 264
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.93
    Marker Score: 3,854
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.93
    Marker Score: 488
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.93
    Marker Score: 9,386
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.92
    Marker Score: 583
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.92
    Marker Score: 31,290
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 669
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.91
    Marker Score: 3,386
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.91
    Marker Score: 578
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.91
    Marker Score: 1,585
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9
    Marker Score: 2,461
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,157
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.9
    Marker Score: 654
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.89
    Marker Score: 2,419
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.89
    Marker Score: 505
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.88
    Marker Score: 1,733
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.88
    Marker Score: 402
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.88
    Marker Score: 948
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.86
    Marker Score: 920
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.84
    Marker Score: 31,015
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.84
    Marker Score: 5,451
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13,015
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.83
    Marker Score: 555
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.83
    Marker Score: 774
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.82
    Marker Score: 562
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.82
    Marker Score: 694
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.82
    Marker Score: 1,164
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.82
    Marker Score: 602
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.82
    Marker Score: 3,416
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.82
    Marker Score: 7,058
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.82
    Marker Score: 400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.82
    Marker Score: 282
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.81
    Marker Score: 764
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.81
    Marker Score: 234
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.81
    Marker Score: 42,838
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.8
    Marker Score: 328
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.79
    Marker Score: 497
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.79
    Marker Score: 3,379
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.79
    Marker Score: 7,395
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.79
    Marker Score: 278
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 697
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.78
    Marker Score: 716
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.78
    Marker Score: 522
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.77
    Marker Score: 7,772
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.77
    Marker Score: 184
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.76
    Marker Score: 2,404
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.76
    Marker Score: 149
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.76
    Marker Score: 166
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.76
    Marker Score: 732
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.75
    Marker Score: 312
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.75
    Marker Score: 1,231
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.75
    Marker Score: 3,679
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.75
    Marker Score: 365
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.75
    Marker Score: 585
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.75
    Marker Score: 743
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.75
    Marker Score: 1,820

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPS30 is a mitochondrial protein that belongs to the ribosomal protein S30 family. It is a 39-kDa protein that is highly conserved across species, suggesting its critical function in mitochondrial translation. The protein is composed of two alpha-helices and a beta-sheet, which are essential for its interactions with other ribosomal proteins and mRNA. MRPS30 is a structural constituent of the large ribosomal subunit and is involved in the binding of mRNA to the ribosome. **Pathways and Functions:** MRPS30 is a key player in the mitochondrial translation process, which is essential for the production of mitochondrial proteins that are involved in energy metabolism, DNA replication, and cell signaling. The protein is involved in the following pathways: * **Mitochondrial translation initiation**: MRPS30 interacts with other ribosomal proteins to bind to the small subunit of the ribosome, which is necessary for the initiation of translation. * **Mitochondrial translation elongation**: MRPS30 is involved in the elongation phase of translation, where it interacts with the large subunit of the ribosome to facilitate the movement of the ribosome along the mRNA. * **Mitochondrial translation termination**: MRPS30 is also involved in the termination phase of translation, where it interacts with the release factor proteins to facilitate the release of the completed protein from the ribosome. **Clinical Significance:** Dysregulation of MRPS30 has been implicated in various human diseases, including: * **Mitochondrial disorders**: Mutations in the MRPS30 gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MELAS syndrome. * **Cancer**: Overexpression of MRPS30 has been observed in various types of cancer, including pancreatic cancer and osteosarcoma. * **Neurodegenerative diseases**: MRPS30 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In addition, MRPS30 has been identified as a potential biomarker for various diseases, including cancer and mitochondrial disorders. Further research is needed to fully understand the role of MRPS30 in human health and disease. **Conclusion:** In conclusion, MRPS30 is a crucial component of mitochondrial translation, and its dysregulation has been implicated in various human diseases. Further research is needed to fully understand the role of MRPS30 in human health and disease, and to explore its potential as a therapeutic target for various diseases. As an expert immunologist, it is essential to recognize the significance of MRPS30 in mitochondrial biology and its implications for human health and disease.

Genular Protein ID: 1270438086

Symbol: RT30_HUMAN

Name: 39S ribosomal protein S30, mitochondrial

UniProtKB Accession Codes:

Q9NP92 Q96I91 Q96Q19 Q9H0P8 Q9NSF9 Q9NZ76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 56 EPD 1 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 64 PDBsum 58 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10640817

Title: Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52.

PubMed ID: 10640817

DOI: 10.1159/000015397

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27023846

Title: Structure and function of the mitochondrial ribosome.

PubMed ID: 27023846

DOI: 10.1146/annurev-biochem-060815-014343

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

Sequence Information:

  • Length: 439
  • Mass: 50365
  • Checksum: 2A22DB6170F6D04F
  • Sequence:
    • MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL 
RRIERWQATV HAAESVDEKL RILTKMQFMK YMVYPQTFAL NADRWYQYFT KTVFLSGLPP 
PPAEPEPEPE PEPEPALDLA ALRAVACDCL LQEHFYLRRR RRVHRYEESE VISLPFLDQL 
VSTLVGLLSP HNPALAAAAL DYRCPVHFYW VRGEEIIPRG HRRGRIDDLR YQIDDKPNNQ 
IRISKQLAEF VPLDYSVPIE IPTIKCKPDK LPLFKRQYEN HIFVGSKTAD PCCYGHTQFH 
LLPDKLRRER LLRQNCADQI EVVFRANAIA SLFAWTGAQA MYQGFWSEAD VTRPFVSQAV 
ITDGKYFSFF CYQLNTLALT TQADQNNPRK NICWGTQSKP LYETIEDNDV KGFNDDVLLQ 
IVHFLLNRPK EEKSQLLEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.