Details for: CEACAM4

Gene ID: 1089

Symbol: CEACAM4

Ensembl ID: ENSG00000105352

Description: CEA cell adhesion molecule 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.11
    Marker Score: 2885
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.11
    Marker Score: 674
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.99
    Marker Score: 4131
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.87
    Marker Score: 615
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.79
    Marker Score: 800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.62
    Marker Score: 34942
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.53
    Marker Score: 277
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.52
    Marker Score: 1008
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.46
    Marker Score: 523
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.45
    Marker Score: 1127
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.44
    Marker Score: 322
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.43
    Marker Score: 5020
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.4
    Marker Score: 646
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.34
    Marker Score: 153
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.34
    Marker Score: 205
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.32
    Marker Score: 317
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.31
    Marker Score: 159
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.3
    Marker Score: 105
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.28
    Marker Score: 338
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.26
    Marker Score: 618
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.25
    Marker Score: 108
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.24
    Marker Score: 1447
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 150.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.23
    Marker Score: 70
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.22
    Marker Score: 159
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.2
    Marker Score: 203
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.2
    Marker Score: 138
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.16
    Marker Score: 123
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 163
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.14
    Marker Score: 182
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.12
    Marker Score: 795
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.12
    Marker Score: 127
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 255
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.11
    Marker Score: 2867.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.11
    Marker Score: 202
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.1
    Marker Score: 157
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 287

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Other Information

**Key characteristics:** * Protein type: transmembrane protein * Ensembl ID: ENSG00000105352 * Protein length: 133 amino acids * Subcellular localization: cell surface, membrane, phagosome, plasma membrane, protein tyrosine kinase binding site, regulation of immune system process, signal transduction * Expression: blood vessel endothelial cell, enterocyte of epithelium of large intestine, colon goblet cell, intestinal crypt stem cell of small intestine, transit amplifying cell of small intestine, goblet cell, enterocyte of epithelium of small intestine, CD1c-positive myeloid dendritic cell, myeloid dendritic cell, transit amplifying cell of colon **Pathways and functions:** * Cell adhesion: CEACAM4 is a cell adhesion molecule that is expressed on the surface of endothelial cells, enterocytes, and immune cells. It is involved in cell adhesion by binding to cadherins on the surface of adjacent cells. * Cell signaling: CEACAM4 is also involved in cell signaling pathways. It is a ligand for integrins, which are cell adhesion molecules that are expressed on the surface of endothelial cells and immune cells. When CEACAM4 binds to integrins, it recruits the integrin-mediated signaling complex to the cell surface, which leads to cell signaling. * Immune regulation: CEACAM4 is also involved in the regulation of the immune system process. It is expressed on the surface of immune cells, including macrophages, dendritic cells, and lymphocytes. CEACAM4 binds to cadherins on the surface of immune cells, which triggers the activation of the immune cell. This activation leads to the recruitment of immune cells to sites of infection or injury. **Clinical significance:** Mutations in the CEACAM4 gene have been linked to several human diseases, including colorectal cancer, breast cancer, and lung cancer. These mutations can lead to the loss of CEACAM4 protein expression or function, which can result in the uncontrolled growth of cancer cells.

Genular Protein ID: 3805421102

Symbol: CEAM4_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 4

UniProtKB Accession Codes:

O75871 Q03715 Q7LDZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2050678

Title: Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.

PubMed ID: 2050678

DOI: 10.1016/s0021-9258(18)99029-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 25567962

Title: The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria.

PubMed ID: 25567962

DOI: 10.1189/jlb.2ab0813-449rr

Sequence Information:

  • Length: 244
  • Mass: 25909
  • Checksum: C7D2CB0D1CFDC2EC
  • Sequence:
    • MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE 
TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY 
TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG 
RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA 
DVVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.