Details for: CEACAM4

Gene ID: 1089

Symbol: CEACAM4

Ensembl ID: ENSG00000105352

Description: CEA cell adhesion molecule 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.6511
    Cell Significance Index: -2.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 5.3851
    Cell Significance Index: -2.7700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.3672
    Cell Significance Index: 63.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.9090
    Cell Significance Index: 125.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.9105
    Cell Significance Index: 43.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1443
    Cell Significance Index: 33.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.0925
    Cell Significance Index: -2.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3783
    Cell Significance Index: 29.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7099
    Cell Significance Index: 42.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5860
    Cell Significance Index: 95.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5568
    Cell Significance Index: -1.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3644
    Cell Significance Index: 7.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2684
    Cell Significance Index: 4.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2558
    Cell Significance Index: 48.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0402
    Cell Significance Index: 4.3700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0226
    Cell Significance Index: 0.2800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0121
    Cell Significance Index: 0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0059
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0036
    Cell Significance Index: 0.4100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0031
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0004
    Cell Significance Index: 0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0018
    Cell Significance Index: -0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0056
    Cell Significance Index: -2.5300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0076
    Cell Significance Index: -0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0077
    Cell Significance Index: -2.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0079
    Cell Significance Index: -1.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0089
    Cell Significance Index: -0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0108
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0109
    Cell Significance Index: -1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0121
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0121
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0159
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0177
    Cell Significance Index: -2.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0196
    Cell Significance Index: -2.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0222
    Cell Significance Index: -0.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0225
    Cell Significance Index: -2.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0239
    Cell Significance Index: -1.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0240
    Cell Significance Index: -0.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0256
    Cell Significance Index: -0.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0287
    Cell Significance Index: -1.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0318
    Cell Significance Index: -2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0398
    Cell Significance Index: -1.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0409
    Cell Significance Index: -2.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0423
    Cell Significance Index: -1.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0427
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0430
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0434
    Cell Significance Index: -2.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0448
    Cell Significance Index: -1.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0484
    Cell Significance Index: -2.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0536
    Cell Significance Index: -0.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0545
    Cell Significance Index: -1.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0583
    Cell Significance Index: -0.8500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0600
    Cell Significance Index: -0.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0604
    Cell Significance Index: -2.6700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0611
    Cell Significance Index: -0.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0613
    Cell Significance Index: -2.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0621
    Cell Significance Index: -0.5300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0627
    Cell Significance Index: -0.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0634
    Cell Significance Index: -2.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0655
    Cell Significance Index: -2.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0695
    Cell Significance Index: -2.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0734
    Cell Significance Index: -2.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0776
    Cell Significance Index: -2.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0785
    Cell Significance Index: -2.5000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0795
    Cell Significance Index: -0.7400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0798
    Cell Significance Index: -0.8000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0840
    Cell Significance Index: -0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0865
    Cell Significance Index: -2.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0869
    Cell Significance Index: -2.2200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0889
    Cell Significance Index: -0.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0912
    Cell Significance Index: -2.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0952
    Cell Significance Index: -2.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1026
    Cell Significance Index: -1.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1028
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1033
    Cell Significance Index: -1.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1034
    Cell Significance Index: -2.5800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1043
    Cell Significance Index: -1.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1045
    Cell Significance Index: -2.6100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1048
    Cell Significance Index: -2.0900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1049
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1049
    Cell Significance Index: -2.6200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1062
    Cell Significance Index: -0.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1070
    Cell Significance Index: -2.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1073
    Cell Significance Index: -1.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1078
    Cell Significance Index: -0.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1082
    Cell Significance Index: -1.5500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1130
    Cell Significance Index: -1.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1147
    Cell Significance Index: -1.9600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1156
    Cell Significance Index: -1.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1156
    Cell Significance Index: -2.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1179
    Cell Significance Index: -1.9100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1180
    Cell Significance Index: -1.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1185
    Cell Significance Index: -2.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1194
    Cell Significance Index: -2.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** CEACAM4 is primarily expressed on the surface of cells, where it interacts with other molecules to regulate immune responses. 2. **Cell Adhesion and Phagocytosis:** CEACAM4 mediates cell-cell and cell-matrix interactions, influencing cell adhesion and phagocytic processes. 3. **Signal Transduction:** CEACAM4 can interact with protein tyrosine kinases, initiating signaling cascades that regulate immune responses and cellular growth. 4. **Regulation of Immune System Processes:** CEACAM4 modulates the activity of immune cells, including myeloid dendritic cells, which are essential for antigen presentation and immune activation. **Pathways and Functions:** 1. **Regulation of Immune Response:** CEACAM4 interacts with other molecules to regulate immune responses, including activation, proliferation, and differentiation of immune cells. 2. **Cell Adhesion and Migration:** CEACAM4 mediates cell-cell and cell-matrix interactions, influencing cell migration, invasion, and metastasis in cancer. 3. **Phagocytosis and Antigen Presentation:** CEACAM4 is involved in phagocytic processes and antigen presentation by myeloid dendritic cells, which is essential for initiating immune responses. 4. **Signal Transduction and Tyrosine Phosphorylation:** CEACAM4 interacts with protein tyrosine kinases, initiating signaling cascades that regulate cellular growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** CEACAM4 has been implicated in the development and progression of various cancers, including colorectal, lung, and breast cancer. 2. **Autoimmune Disorders:** Dysregulation of CEACAM4 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Inflammatory Conditions:** CEACAM4 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory conditions, such as atherosclerosis and inflammatory bowel disease. 4. **Infectious Diseases:** CEACAM4 plays a role in the regulation of immune responses to infections, and its dysregulation has been linked to susceptibility to certain infections. In conclusion, CEACAM4 is a multifunctional protein that plays a crucial role in regulating the immune system. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Further research is needed to fully understand the mechanisms by which CEACAM4 regulates immune responses and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 3805421102

Symbol: CEAM4_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 4

UniProtKB Accession Codes:

O75871 Q03715 Q7LDZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2050678

Title: Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.

PubMed ID: 2050678

DOI: 10.1016/s0021-9258(18)99029-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 25567962

Title: The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria.

PubMed ID: 25567962

DOI: 10.1189/jlb.2ab0813-449rr

Sequence Information:

  • Length: 244
  • Mass: 25909
  • Checksum: C7D2CB0D1CFDC2EC
  • Sequence:
    • MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE 
TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY 
TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG 
RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA 
DVVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.