PPARGC1A | ENSG00000109819 | NCBI 10891

Details for: PPARGC1A

Gene ID: 10891

Symbol: PPARGC1A

Ensembl ID: ENSG00000109819

Description: PPARG coactivator 1 alpha

Associated with

Activation of ppargc1a (pgc-1alpha) by phosphorylation
(R-HSA-2151209)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Circadian clock
(R-HSA-400253)
Developmental biology
(R-HSA-1266738)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Heme signaling
(R-HSA-9707616)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial biogenesis
(R-HSA-1592230)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Adipose tissue development
(GO:0060612)
Brown fat cell differentiation
(GO:0050873)
Cellular respiration
(GO:0045333)
Cellular response to oxidative stress
(GO:0034599)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Circadian regulation of gene expression
(GO:0032922)
Cytosol
(GO:0005829)
Digestion
(GO:0007586)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Energy homeostasis
(GO:0097009)
Fatty acid oxidation
(GO:0019395)
Gluconeogenesis
(GO:0006094)
Intracellular glucose homeostasis
(GO:0001678)
Lncrna binding
(GO:0106222)
Mitochondrion organization
(GO:0007005)
Mrna processing
(GO:0006397)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Neuron apoptotic process
(GO:0051402)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of cellular respiration
(GO:1901857)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of mitochondrial dna metabolic process
(GO:1901860)
Positive regulation of mitochondrion organization
(GO:0010822)
Positive regulation of muscle tissue development
(GO:1901863)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna-templated transcription
(GO:0006355)
Respiratory electron transport chain
(GO:0022904)
Response to dietary excess
(GO:0002021)
Response to muscle activity
(GO:0014850)
Response to starvation
(GO:0042594)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna splicing
(GO:0008380)
Sequence-specific dna binding
(GO:0043565)
Temperature homeostasis
(GO:0001659)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription factor binding
(GO:0008134)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Genular Protein ID: 808240951

Symbol: PRGC1_HUMAN

Name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

UniProtKB Accession Codes:

Q9UBK2 B7Z406 G8DM16 I3RTT5 I3RTT6 I3RTT7 I3RTT8 I3RTT9 Q3LIG1 Q4W5M7 Q9UN32

Database IDs:

Citations:

PubMed ID: 10585775

Title: Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.

PubMed ID: 10585775

DOI: 10.1006/geno.1999.5977

PubMed ID: 10643692

Title: Cloning and mRNA tissue distribution of human PPARgamma coactivator-1.

PubMed ID: 10643692

DOI: 10.1038/sj.ijo.0801106

PubMed ID: 10713165

Title: A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.

PubMed ID: 10713165

DOI: 10.1128/mcb.20.7.2411-2422.2000

PubMed ID: 22009745

Title: Characterization of novel peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) isoform in human liver.

PubMed ID: 22009745

DOI: 10.1074/jbc.m111.227496

PubMed ID: 22589246

Title: A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.

PubMed ID: 22589246

DOI: 10.1093/hmg/dds177

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 17050673

Title: Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.

PubMed ID: 17050673

DOI: 10.1101/gad.1483906

PubMed ID: 16753578

Title: GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.

PubMed ID: 16753578

DOI: 10.1016/j.cmet.2006.04.013

PubMed ID: 20005308

Title: Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5.

PubMed ID: 20005308

DOI: 10.1016/j.bbapap.2009.11.023

PubMed ID: 21376232

Title: PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease.

PubMed ID: 21376232

DOI: 10.1016/j.cell.2011.02.010

PubMed ID: 23142079

Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

PubMed ID: 23142079

DOI: 10.1016/j.molcel.2012.09.030

PubMed ID: 22064484

Title: RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism.

PubMed ID: 22064484

DOI: 10.1128/mcb.05674-11

PubMed ID: 23836911

Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

PubMed ID: 23836911

DOI: 10.1074/jbc.m113.489674

Sequence Information:

Length: 798
Mass: 91027
Checksum: 97DDD3643051A5F1
Sequence:

MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS FLGGLKWCSD 
QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP VDEDGLPSFD ALTDGDVTTD 
NEASPSSMPD GTPPPQEAEE PSLLKKLLLA PANTQLSYNE CSGLSTQNHA NHNHRIRTNP 
AIVKTENSWS NKAKSICQQQ KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK 
KSHTQSQSQH LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP 
PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE QSELYAQLSK 
SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI SQELQDSRQL ENKDVSSDWQ 
GQICSSTDSD QCYLRETLEA SKQVSPCSTR KQLQDQEIRA ELNKHFGHPS QAVFDDEADK 
TGELRDSDFS NEQFSKLPMF INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC 
SSFNSPCRDS VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC 
YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY RREYEKRESE 
RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF GEIEECTVNL RDDGDSYGFI 
TYRYTCDAFA ALENGYTLRR SNETDFELYF CGRKQFFKSN YADLDSNSDD FDPASTKSKY 
DSLDFDSLLK EAQRSLRR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPARGC1A

Associated with

Other Information

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. PubMed ID: 10585775

Cloning and mRNA tissue distribution of human PPARgamma coactivator-1. PubMed ID: 10643692

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. PubMed ID: 10713165

Characterization of novel peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) isoform in human liver. PubMed ID: 22009745

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. PubMed ID: 22589246

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. PubMed ID: 17050673

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. PubMed ID: 16753578

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. PubMed ID: 20005308

PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. PubMed ID: 21376232

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. PubMed ID: 23142079

RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism. PubMed ID: 22064484

Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. PubMed ID: 23836911