Details for: CPSF4

Gene ID: 10898

Symbol: CPSF4

Ensembl ID: ENSG00000160917

Description: cleavage and polyadenylation specific factor 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.37
    Marker Score: 2,387
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.22
    Marker Score: 4,799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,970
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 586
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.86
    Marker Score: 1,818
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12,469
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.78
    Marker Score: 984
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27,745
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 289
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.71
    Marker Score: 296
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.7
    Marker Score: 1,086
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,939
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.68
    Marker Score: 4,032
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.66
    Marker Score: 40,892
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.66
    Marker Score: 5,665
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.65
    Marker Score: 2,671
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.65
    Marker Score: 167
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.62
    Marker Score: 667
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.62
    Marker Score: 3,060
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.62
    Marker Score: 5,895
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.62
    Marker Score: 1,049
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.61
    Marker Score: 649
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.61
    Marker Score: 1,276
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.59
    Marker Score: 552
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.58
    Marker Score: 1,330
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.58
    Marker Score: 21,257
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 429
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 613
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.56
    Marker Score: 2,166
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.56
    Marker Score: 4,290
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.55
    Marker Score: 11,781
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.54
    Marker Score: 2,207
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.54
    Marker Score: 5,070
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.54
    Marker Score: 359
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.53
    Marker Score: 186
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.53
    Marker Score: 561
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.53
    Marker Score: 7,875
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1,220
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5,259
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.5
    Marker Score: 203
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 323
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.48
    Marker Score: 1,300
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.47
    Marker Score: 1,290
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.47
    Marker Score: 299
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.47
    Marker Score: 9,419
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.47
    Marker Score: 345
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.47
    Marker Score: 15,974
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.47
    Marker Score: 469
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.46
    Marker Score: 256
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.46
    Marker Score: 127
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.46
    Marker Score: 1,096
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.46
    Marker Score: 138
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.46
    Marker Score: 498
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.45
    Marker Score: 189
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.45
    Marker Score: 644
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2,690
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.44
    Marker Score: 128
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.44
    Marker Score: 1,910
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.44
    Marker Score: 278
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 202
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.44
    Marker Score: 1,807
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.43
    Marker Score: 275
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.43
    Marker Score: 271
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.43
    Marker Score: 386
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.43
    Marker Score: 210
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.43
    Marker Score: 3,724
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.43
    Marker Score: 101
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1,044
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.43
    Marker Score: 158
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.43
    Marker Score: 471
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 411
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.42
    Marker Score: 93
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.42
    Marker Score: 4,264
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.42
    Marker Score: 106
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.42
    Marker Score: 14,479
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 359
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.41
    Marker Score: 91
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.41
    Marker Score: 282
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.41
    Marker Score: 530
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 656
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.41
    Marker Score: 199

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CPSF4 is a highly conserved gene, with high sequence similarity across species. It is expressed in a wide range of cell types, including germ cells, placental villous trophoblast, cerebral cortex GABAergic interneuron, and intestinal epithelial cells. CPSF4 is a zinc-binding protein, which suggests its involvement in protein-protein interactions and RNA binding. The gene is also involved in various cellular processes, including RNA polymerase II transcription, mRNA cleavage and polyadenylation specificity factor complex assembly, and transport of mature mRNA to the cytoplasm. **Pathways and Functions** CPSF4 is involved in several key pathways, including: 1. **mRNA 3'-end processing**: CPSF4 is a subunit of the cleavage and polyadenylation specificity factor complex, which is responsible for the 3'-end processing of pre-mRNA. 2. **RNA polymerase II transcription**: CPSF4 interacts with RNA polymerase II and other transcription factors to regulate gene expression. 3. **Intracellular membrane-bounded organelle**: CPSF4 is involved in the transport of mature mRNA to the cytoplasm, which is mediated by the nuclear pore complex. 4. **Inhibition of host mRNA processing and RNA silencing**: CPSF4 can inhibit the activity of RNA silencing pathways, which are critical for gene regulation. **Clinical Significance** Dysregulation of CPSF4 has been implicated in various diseases, including: 1. **Cancer**: Mutations in CPSF4 have been associated with various types of cancer, including breast cancer and leukemia. 2. **Infectious diseases**: CPSF4 has been shown to play a role in the regulation of host immune responses to viral infections. 3. **Neurological disorders**: Alterations in CPSF4 expression have been implicated in neurological disorders, including autism and schizophrenia. 4. **Genetic disorders**: CPSF4 mutations have been associated with genetic disorders, including intellectual disability and developmental delay. In conclusion, CPSF4 is a critical gene involved in the regulation of mRNA processing and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of CPSF4 in human health and disease.

Genular Protein ID: 3061811276

Symbol: CPSF4_HUMAN

Name: Cleavage and polyadenylation specificity factor subunit 4

UniProtKB Accession Codes:

O95639 D6W5S8 Q6FGE6 Q86TF8 Q9BTW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 5 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9224719

Title: The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins.

PubMed ID: 9224719

DOI: 10.1101/gad.11.13.1703

PubMed ID: 9651582

Title: Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs.

PubMed ID: 9651582

DOI: 10.1016/s1097-2765(00)80099-4

PubMed ID: 14749727

Title: Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed ID: 14749727

DOI: 10.1038/sj.emboj.7600070

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21102410

Title: The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA.

PubMed ID: 21102410

DOI: 10.1038/emboj.2010.287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 269
  • Mass: 30255
  • Checksum: 49444E3EB840464A
  • Sequence:
    • MQEIIASVDH IKFDLEIAVE QQLGAQPLPF PGMDKSGAAV CEFFLKAACG KGGMCPFRHI 
SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS KFGECSNKEC PFLHIDPESK 
IKDCPWYDRG FCKHGPLCRH RHTRRVICVN YLVGFCPEGP SCKFMHPRFE LPMGTTEQPP 
LPQQTQPPAK QSNNPPLQRS SSLIQLTSQN SSPNQQRTPQ VIGVMQSQNS SAGNRGPRPL 
EQVTCYKCGE KGHYANRCTK GHLAFLSGQ

Genular Protein ID: 3899911411

Symbol: B7Z7B0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7B0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 191
  • Mass: 21957
  • Checksum: 65B5B31E6BB1DC1E
  • Sequence:
    • MCPFRHISGE KTVVCKHWLR GLCKKGDQCE FLHEYDMTKM PECYFYSKFG ECSNKECPFL 
HIDPESKIKD CPWYDRGFCK HGPLCRHRHT RRVICVNYLV GFCPEGPSCK FMHPRFELPM 
GTTEQPPLPQ QTQPPAKQRT PQVIGVMQSQ NSSAGNRGPR PLEQVTCYKC GEKGHYANRC 
TKGHLAFLSG Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.