Details for: ADCY3

Gene ID: 109

Symbol: ADCY3

Ensembl ID: ENSG00000138031

Description: adenylate cyclase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.4964
    Cell Significance Index: -25.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.9257
    Cell Significance Index: -23.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.4062
    Cell Significance Index: -25.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8769
    Cell Significance Index: -23.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3792
    Cell Significance Index: -16.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5409
    Cell Significance Index: -20.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3583
    Cell Significance Index: -25.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.1144
    Cell Significance Index: 34.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7313
    Cell Significance Index: 65.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6341
    Cell Significance Index: 72.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5742
    Cell Significance Index: 315.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0385
    Cell Significance Index: 197.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0042
    Cell Significance Index: 99.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9005
    Cell Significance Index: 25.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8808
    Cell Significance Index: 17.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8634
    Cell Significance Index: 5.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7324
    Cell Significance Index: 262.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7172
    Cell Significance Index: 98.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6002
    Cell Significance Index: 40.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4973
    Cell Significance Index: 80.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4616
    Cell Significance Index: 416.8100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4548
    Cell Significance Index: 2.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4518
    Cell Significance Index: 25.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4287
    Cell Significance Index: 296.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4242
    Cell Significance Index: 46.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3360
    Cell Significance Index: 20.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3236
    Cell Significance Index: 19.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2758
    Cell Significance Index: 6.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2379
    Cell Significance Index: 6.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2221
    Cell Significance Index: 3.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2201
    Cell Significance Index: 43.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1868
    Cell Significance Index: 4.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1428
    Cell Significance Index: 3.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1093
    Cell Significance Index: 3.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1036
    Cell Significance Index: 45.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0937
    Cell Significance Index: 6.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0818
    Cell Significance Index: 10.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0718
    Cell Significance Index: 8.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0676
    Cell Significance Index: 12.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0286
    Cell Significance Index: 0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0245
    Cell Significance Index: 1.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0223
    Cell Significance Index: 1.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0184
    Cell Significance Index: 0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0114
    Cell Significance Index: 6.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0086
    Cell Significance Index: 5.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0085
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0026
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0272
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0284
    Cell Significance Index: -20.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0326
    Cell Significance Index: -24.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0346
    Cell Significance Index: -25.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0426
    Cell Significance Index: -26.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0457
    Cell Significance Index: -25.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0562
    Cell Significance Index: -1.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0676
    Cell Significance Index: -9.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0698
    Cell Significance Index: -20.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0701
    Cell Significance Index: -4.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0779
    Cell Significance Index: -5.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1005
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1097
    Cell Significance Index: -12.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1272
    Cell Significance Index: -26.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1345
    Cell Significance Index: -22.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1350
    Cell Significance Index: -13.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1397
    Cell Significance Index: -18.0500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1434
    Cell Significance Index: -1.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1543
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1728
    Cell Significance Index: -19.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1795
    Cell Significance Index: -11.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2275
    Cell Significance Index: -23.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2409
    Cell Significance Index: -3.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2499
    Cell Significance Index: -19.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2774
    Cell Significance Index: -2.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2787
    Cell Significance Index: -20.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2796
    Cell Significance Index: -4.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3028
    Cell Significance Index: -15.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3377
    Cell Significance Index: -17.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3557
    Cell Significance Index: -18.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3676
    Cell Significance Index: -7.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3679
    Cell Significance Index: -9.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4141
    Cell Significance Index: -13.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4157
    Cell Significance Index: -13.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4157
    Cell Significance Index: -26.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4293
    Cell Significance Index: -6.5200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4421
    Cell Significance Index: -4.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4668
    Cell Significance Index: -5.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4724
    Cell Significance Index: -9.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4776
    Cell Significance Index: -13.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4881
    Cell Significance Index: -10.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4916
    Cell Significance Index: -22.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5071
    Cell Significance Index: -17.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5425
    Cell Significance Index: -11.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5544
    Cell Significance Index: -19.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5990
    Cell Significance Index: -21.9900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6042
    Cell Significance Index: -8.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADCY3 is a constitutively active, G-protein coupled receptor (GPCR) that activates adenylate cyclase, resulting in increased cAMP production. This enzyme is widely expressed in various cell types, including neurons, immune cells, and epithelial cells. ADCY3 is unique in its ability to activate adenylate cyclase in the absence of G-protein coupling, making it a key player in cell signaling pathways. **Pathways and Functions:** ADCY3 is involved in numerous signaling pathways, including: 1. **Adenylate cyclase-activating GPCR signaling pathway:** ADCY3 activates adenylate cyclase, leading to increased cAMP production and subsequent signaling cascades. 2. **Acrosome reaction:** ADCY3 plays a crucial role in the acrosome reaction, a process essential for sperm motility and fertilization. 3. **Anti-inflammatory response:** ADCY3 modulates the anti-inflammatory response by regulating the production of anti-inflammatory cytokines, such as IL-10. 4. **Leishmania infection:** ADCY3 is involved in the regulation of Leishmania parasite growth and survival, highlighting its role in parasitic infection pathways. 5. **Neurotransmitter signaling:** ADCY3 is expressed in neurons and plays a role in neurotransmitter signaling, including GABA receptor activation. **Clinical Significance:** ADCY3 is implicated in various diseases, including: 1. **Infectious diseases:** ADCY3 is involved in the regulation of Leishmania parasite growth and survival, making it a potential target for therapeutic interventions. 2. **Autoimmune disorders:** ADCY3 modulates the anti-inflammatory response, which may contribute to autoimmune diseases, such as rheumatoid arthritis. 3. **Cancer:** ADCY3 is overexpressed in certain types of cancer, including breast and lung cancer, suggesting its role in tumorigenesis. 4. **Neurological disorders:** ADCY3 is involved in neurotransmitter signaling, which may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease. In conclusion, ADCY3 is a multifunctional enzyme that plays a crucial role in immune regulation, cellular signaling, and disease pathology. Further research is necessary to fully elucidate the mechanisms underlying ADCY3's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3006367378

Symbol: ADCY3_HUMAN

Name: Adenylate cyclase type 3

UniProtKB Accession Codes:

O60266 B3KT86 Q53T54 Q9UDB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 14 RefSeq 2 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9920776

Title: Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.

PubMed ID: 9920776

DOI: 10.1006/bbrc.1998.9983

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 15705663

Title: Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function.

PubMed ID: 15705663

DOI: 10.1210/me.2004-0318

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29311636

Title: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.

PubMed ID: 29311636

DOI: 10.1038/s41588-017-0022-7

PubMed ID: 29311637

Title: Loss-of-function mutations in ADCY3 cause monogenic severe obesity.

PubMed ID: 29311637

DOI: 10.1038/s41588-017-0023-6

Sequence Information:

  • Length: 1144
  • Mass: 128960
  • Checksum: B75D39DD0A8ACA12
  • Sequence:
    • MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLASLAV AGIGLVLDII 
LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ IFSYLGLNFA RAHAASDTVG WQVFFVFSFF 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 
YLEEKGIETY LIIASKPEVK KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS 
SGSTSEKPEE QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 
QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE ILIDPWLMTN 
YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR TRWARNTWAM LAIFILVMAN 
VVDMLSCLQY YTGPSNATAG METEGSCLEN PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM 
LLVAGAVATI NLYAWRPVFD EYDHKRFREH DLPMVALEQM QGFNPGLNGT DRLPLVPSKY 
SMTVMVFLMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 
ARHFLGSKKR DEELYSQTYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFASSN KEDKSERERW QHLADLADFA 
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDKLATFPN GPSVTLPHQV 
VDNS

Genular Protein ID: 4183842089

Symbol: B7ZLX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLX9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 18 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1145
  • Mass: 129057
  • Checksum: 22F450FB620AE7C6
  • Sequence:
    • MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLAV AGIGLVLDII 
LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ IFSYLGLNFA RAHAASDTVG WQVFFVFSFF 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 
YLEEKGIETY LIIASKPEVK KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS 
SGSTSEKPEE QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 
QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE ILIDPWLMTN 
YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR TRWARNTWAM LAIFILVMAN 
VVDMLSCLQY YTGPSNATAG METEGSCLEN PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM 
LLVAGAVATI NLYAWRPVFD EYDHKRFREH DLPMVALEQM QGFNPGLNGT DSRLPLVPSK 
YSMTVMVFLM MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 
VARHFLGSKK RDEELYSQTY DEIGVMFASL PNFADFYTEE SINNGGIECL RFLNEIISDF 
DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFASS NKEDKSERER WQHLADLADF 
ALAMKDTLTN INNQSFNNFM LRIGMNKGGV LAGVIGARKP HYDIWGNTVN VASRMESTGV 
MGNIQVVEET QVILREYGFR FVRRGPIFVK GKGELLTFFL KGRDKLATFP NGPSVTLPHQ 
VVDNS

Genular Protein ID: 1128294450

Symbol: A0A0A0MSC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSC1

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 18 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1145
  • Mass: 129047
  • Checksum: B0B4EDD6F20AE7F6
  • Sequence:
    • MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLASLAV AGIGLVLDII 
LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ IFSYLGLNFA RAHAASDTVG WQVFFVFSFF 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 
YLEEKGIETY LIIASKPEVK KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS 
SGSTSEKPEE QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 
QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE ILIDPWLMTN 
YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR TRWARNTWAM LAIFILVMAN 
VVDMLSCLQY YTGPSNATAG METEGSCLEN PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM 
LLVAGAVATI NLYAWRPVFD EYDHKRFREH DLPMVALEQM QGFNPGLNGT DSRLPLVPSK 
YSMTVMVFLM MLSFYYFSRH VEKLARTLFL WKIEVHDQKE RVYEMRRWNE ALVTNMLPEH 
VARHFLGSKK RDEELYSQTY DEIGVMFASL PNFADFYTEE SINNGGIECL RFLNEIISDF 
DSLLDNPKFR VITKIKTIGS TYMAASGVTP DVNTNGFASS NKEDKSERER WQHLADLADF 
ALAMKDTLTN INNQSFNNFM LRIGMNKGGV LAGVIGARKP HYDIWGNTVN VASRMESTGV 
MGNIQVVEET QVILREYGFR FVRRGPIFVK GKGELLTFFL KGRDKLATFP NGPSVTLPHQ 
VVDNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.