Details for: CEACAMP1

Gene ID: 1090

Symbol: CEACAMP1

Ensembl ID: ENSG00000233681

Description: CEA cell adhesion molecule pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 15.0073
    Cell Significance Index: 491.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 14.1032
    Cell Significance Index: 449.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 13.4019
    Cell Significance Index: 279.7100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 5.1047
    Cell Significance Index: 60.0200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 4.2830
    Cell Significance Index: 87.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.5185
    Cell Significance Index: 52.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2489
    Cell Significance Index: 6.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1111
    Cell Significance Index: 1.2100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1078
    Cell Significance Index: 0.9500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0903
    Cell Significance Index: 1.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0454
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0254
    Cell Significance Index: 0.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0222
    Cell Significance Index: 0.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0031
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0085
    Cell Significance Index: -1.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0086
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0086
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0098
    Cell Significance Index: -0.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0138
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0166
    Cell Significance Index: -0.1700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0171
    Cell Significance Index: -0.2600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0183
    Cell Significance Index: -0.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0183
    Cell Significance Index: -0.3100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0205
    Cell Significance Index: -0.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0206
    Cell Significance Index: -0.1700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0209
    Cell Significance Index: -0.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0218
    Cell Significance Index: -0.3100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0235
    Cell Significance Index: -0.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0240
    Cell Significance Index: -0.5300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0253
    Cell Significance Index: -0.3200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0276
    Cell Significance Index: -0.3000
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0281
    Cell Significance Index: -0.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0313
    Cell Significance Index: -0.3200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0323
    Cell Significance Index: -0.3100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0336
    Cell Significance Index: -0.3700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0385
    Cell Significance Index: -0.3500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0416
    Cell Significance Index: -0.3200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0425
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0426
    Cell Significance Index: -0.4000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0492
    Cell Significance Index: -0.4300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0499
    Cell Significance Index: -0.4400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0538
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0555
    Cell Significance Index: -0.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0569
    Cell Significance Index: -0.6800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0605
    Cell Significance Index: -0.3800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0624
    Cell Significance Index: -0.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0720
    Cell Significance Index: -0.9400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0769
    Cell Significance Index: -0.8800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0815
    Cell Significance Index: -0.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1126
    Cell Significance Index: -1.3500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1181
    Cell Significance Index: -1.3500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1409
    Cell Significance Index: -1.6000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1416
    Cell Significance Index: -1.6400
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1423
    Cell Significance Index: -1.7200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1502
    Cell Significance Index: -1.6300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1540
    Cell Significance Index: -1.7100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2620
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAMP1 is a pseudogene of the CEACAM1 gene, which encodes a cell adhesion molecule involved in various cellular processes, including cell-cell adhesion, migration, and signaling. The pseudogenic status of CEACAMP1, however, suggests that it may have evolved to have distinct expression patterns and regulatory mechanisms compared to its functional counterpart. Notably, CEACAMP1 is significantly expressed in retinal rod cells, oligodendrocyte precursor cells, retinal pigment epithelial cells, ependymal cells, astrocytes, pigmented ciliary epithelial cells, and specific types of retinal ganglion cells, as well as in cerebellar granule cell precursors and GABAergic neurons. This widespread expression in the CNS suggests that CEACAMP1 may play a role in maintaining tissue homeostasis, regulating cellular migration, and modulating synaptic transmission. **Pathways and Functions:** Despite its pseudogenic status, CEACAMP1 has been implicated in various cellular processes, including: 1. **Cell-cell adhesion**: CEACAMP1 may participate in cell-cell adhesion by interacting with other cell surface molecules, influencing the formation and maintenance of tissue boundaries. 2. **Cell migration**: CEACAMP1 may regulate cellular migration by modulating the activity of small GTPases, such as Rho GTPases, which play critical roles in cell migration and cytoskeletal dynamics. 3. **Signaling pathways**: CEACAMP1 may interact with signaling molecules, such as receptors and kinases, to modulate intracellular signaling cascades involved in cellular responses to environmental cues. 4. **Synaptic transmission**: CEACAMP1 may influence synaptic transmission by regulating the activity of ion channels, neurotransmitter receptors, and synaptic proteins, thereby modulating neuronal communication. **Clinical Significance:** The expression of CEACAMP1 in various CNS cell types and its potential involvement in cellular processes suggest that dysregulation of CEACAMP1 may contribute to the pathogenesis of neurological disorders. Some potential areas of clinical significance include: 1. **Neurodegenerative diseases**: CEACAMP1 dysregulation may contribute to the development of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Neurodevelopmental disorders**: CEACAMP1 may play a role in the development and maintenance of neural circuits, and dysregulation of CEACAMP1 may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: CEACAMP1 has been implicated in cancer progression, particularly in colorectal cancer, where it may influence cell adhesion, migration, and invasion. In conclusion, CEACAMP1 is a pseudogene with a unique expression profile in the CNS, and its dysregulation may contribute to the pathogenesis of various neurological disorders. Further investigation into the functions and implications of CEACAMP1 is necessary to fully understand its role in human disease and to develop novel therapeutic strategies for the treatment of CNS disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.