DHRS4 | ENSG00000157326 | NCBI 10901

Details for: DHRS4

Gene ID: 10901

Symbol: DHRS4

Ensembl ID: ENSG00000157326

Description: dehydrogenase/reductase 4

Associated with

Peroxisomal protein import
(R-HSA-9033241)
Protein localization
(R-HSA-9609507)
Ra biosynthesis pathway
(R-HSA-5365859)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Signal transduction
(R-HSA-162582)
3-keto sterol reductase activity
(GO:0000253)
3beta-hydroxy-5beta-steroid dehydrogenase activity
(GO:0033703)
Alcohol dehydrogenase [nad(p)+] activity
(GO:0018455)
Alcohol metabolic process
(GO:0006066)
Carbonyl reductase (nadph) activity
(GO:0004090)
Cellular ketone metabolic process
(GO:0042180)
Cytosol
(GO:0005829)
Endoplasmic reticulum membrane
(GO:0005789)
Identical protein binding
(GO:0042802)
Mitochondrion
(GO:0005739)
Nadp-retinol dehydrogenase activity
(GO:0052650)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
(GO:0016655)
Peroxisomal matrix
(GO:0005782)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Retinal dehydrogenase activity
(GO:0001758)
Retinal metabolic process
(GO:0042574)
Retinol metabolic process
(GO:0042572)
Steroid metabolic process
(GO:0008202)

Other Information

Proteins

Peroxisomal short-chain alcohol dehydrogenase

Genular Protein ID: 1520073248

Symbol: DHRS4_HUMAN

Name: Peroxisomal short-chain alcohol dehydrogenase

UniProtKB Accession Codes:

Q9BTZ2 B2RB10 B7WNS9 D3YTB8 E2QRL8 O95162 Q20CR0 Q2LC19 Q2LE81 Q58IU4 Q6E0Y1 Q6UWU3 Q71UQ6 Q8TD03 Q9H3N5 Q9NV08

Database IDs:

Citations:

PubMed ID: 10333503

Title: Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.

PubMed ID: 10333503

DOI: 10.1042/bj3400561

PubMed ID: 15473316

Title: cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.

PubMed ID: 15473316

PubMed ID: 17230527

Title: Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.

PubMed ID: 17230527

DOI: 10.1002/ijc.22306

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18571493

Title: Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.

PubMed ID: 18571493

DOI: 10.1016/j.abb.2008.06.002

PubMed ID: 19056333

Title: Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4).

PubMed ID: 19056333

DOI: 10.1016/j.abb.2008.11.014

PubMed ID: 19027726

Title: The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.

PubMed ID: 19027726

DOI: 10.1016/j.cbi.2008.10.040

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23128527

Title: Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil.

PubMed ID: 23128527

DOI: 10.1159/000343326

PubMed ID: 22227495

Title: Identification of a novel isoform of DHRS4 protein with a nuclear localization signal.

PubMed ID: 22227495

DOI: 10.1016/j.gene.2011.12.033

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27323117

Title: CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.

PubMed ID: 27323117

DOI: 10.4238/gmr.15027752

Sequence Information:

Length: 278
Mass: 29537
Checksum: 3B06A229E1BBE47B
Sequence:

MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR RLAQDGAHVV 
VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV ATAVKLHGGI DILVSNAAVN 
PFFGSIMDVT EEVWDKTLDI NVKAPALMTK AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS 
PYNVSKTALL GLTKTLAIEL APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR 
RLGEPEDCAG IVSFLCSEDA SYITGETVVV GGGTPSRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DHRS4

Associated with

Other Information

Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. PubMed ID: 10333503

cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. PubMed ID: 15473316

Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. PubMed ID: 17230527

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity. PubMed ID: 18571493

Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). PubMed ID: 19056333

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. PubMed ID: 19027726

Initial characterization of the human central proteome. PubMed ID: 21269460

Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil. PubMed ID: 23128527

Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. PubMed ID: 22227495

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription. PubMed ID: 27323117