Details for: UTS2

Gene ID: 10911

Symbol: UTS2

Ensembl ID: ENSG00000049247

Description: urotensin 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.48
    Marker Score: 30,372
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.75
    Marker Score: 19,695
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.97
    Marker Score: 17,720
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.79
    Marker Score: 4,592
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,812
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,322
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 382
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.77
    Marker Score: 2,438
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1,044
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.53
    Marker Score: 1,384
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.44
    Marker Score: 226
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 886
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.43
    Marker Score: 24,005
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5,879
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 216
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.36
    Marker Score: 1,003
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.34
    Marker Score: 18,189
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.34
    Marker Score: 161
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.33
    Marker Score: 811
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.25
    Marker Score: 274
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.25
    Marker Score: 194
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.25
    Marker Score: 480
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.23
    Marker Score: 147
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.23
    Marker Score: 89
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.23
    Marker Score: 218
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.19
    Marker Score: 76
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.19
    Marker Score: 241
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 88
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 283
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.17
    Marker Score: 153
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 163
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.17
    Marker Score: 157
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 345
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 81
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.16
    Marker Score: 117
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.16
    Marker Score: 63
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.15
    Marker Score: 129
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.14
    Marker Score: 157
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.14
    Marker Score: 159
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.13
    Marker Score: 555
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.13
    Marker Score: 186
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 106
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 66
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 61

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptide ligand:** UTS2 is a 15-amino acid peptide that acts as a ligand for G-protein coupled receptors (GPCRs), specifically the UTS2 receptor. 2. **Signaling pathways:** UTS2 is involved in various signaling pathways, including Gαq signaling, GPCR downstream signaling, and hormone activity. 3. **Cellular expression:** UTS2 is expressed in amacrine cells, ON-bipolar cells, OFF-bipolar cells, retina horizontal cells, intestinal crypt stem cells, enterocytes, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and absorptive cells. 4. **Peptide ligand-binding receptors:** UTS2 binds to UTS2 receptors, which are GPCRs that activate downstream signaling cascades. **Pathways and Functions:** 1. **Blood vessel diameter maintenance:** UTS2 regulates blood vessel diameter through Gαq signaling, which modulates smooth muscle contraction and relaxation. 2. **Chemical synaptic transmission:** UTS2 is involved in neurotransmission, particularly in the retina, where it modulates the activity of amacrine cells and bipolar cells. 3. **Regulation of blood pressure:** UTS2 plays a role in regulating blood pressure through its effects on the cardiovascular system. 4. **Muscle contraction:** UTS2 modulates muscle contraction in various tissues, including smooth muscle and skeletal muscle. 5. **Synapse formation and maintenance:** UTS2 is involved in synapse formation and maintenance, particularly in the retina and central nervous system. **Clinical Significance:** 1. **Hypertension:** Dysregulation of UTS2 signaling has been implicated in the development of hypertension, highlighting its potential as a therapeutic target. 2. **Neurological disorders:** UTS2's involvement in neurotransmission and synaptic plasticity makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease:** UTS2's role in regulating blood vessel diameter and blood pressure makes it a potential therapeutic target for cardiovascular disease. 4. **Cancer:** UTS2's expression in intestinal crypt stem cells and enterocytes raises questions about its potential role in cancer development and progression. In conclusion, UTS2 is a multifaceted gene that plays a crucial role in various physiological processes, including immune regulation, cardiovascular function, and neurotransmission. Further research is needed to fully elucidate the mechanisms by which UTS2 regulates these processes and to explore its potential therapeutic applications.

Genular Protein ID: 3494090361

Symbol: UTS2_HUMAN

Name: Urotensin-2

UniProtKB Accession Codes:

O95399 Q5H8X7 Q6UXF6 Q9UKP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9861051

Title: Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.

PubMed ID: 9861051

DOI: 10.1073/pnas.95.26.15803

PubMed ID: 10499587

Title: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

PubMed ID: 10499587

DOI: 10.1038/45809

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 124
  • Mass: 14296
  • Checksum: C7A5FC7EFE00D312
  • Sequence:
    • MYKLASCCLL FIGFLNPLLS LPLLDSREIS FQLSAPHEDA RLTPEELERA SLLQILPEML 
GAERGDILRK ADSSTNIFNP RGNLRKFQDF SGQDPNILLS HLLARIWKPY KKRETPDCFW 
KYCV

Genular Protein ID: 2627904213

Symbol: A0AVP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0AVP6

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 94
  • Mass: 10994
  • Checksum: 5DF746DCC619D228
  • Sequence:
    • MIYCSPHEDA RLTPEELERA SLLQILPEML GAERGDILRK ADSSTNIFNP RGNLRKFQDF 
SGQDPNILLS HLLARIWKPY KKRETPDCFW KYCV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.