COPS8 | ENSG00000198612 | NCBI 10920

Details for: COPS8

Gene ID: 10920

Symbol: COPS8

Ensembl ID: ENSG00000198612

Description: COP9 signalosome subunit 8

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Dna repair
(R-HSA-73894)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nucleotide excision repair
(R-HSA-5696398)
Post-translational protein modification
(R-HSA-597592)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Vesicle-mediated transport
(R-HSA-5653656)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Cop9 signalosome
(GO:0008180)
Cop9 signalosome assembly
(GO:0010387)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Negative regulation of cell population proliferation
(GO:0008285)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Protein deneddylation
(GO:0000338)
Protein neddylation
(GO:0045116)
Protein phosphorylation
(GO:0006468)
Regulation of protein neddylation
(GO:2000434)

Other Information

Proteins

COP9 signalosome complex subunit 8

Genular Protein ID: 1877036271

Symbol: CSN8_HUMAN

Name: COP9 signalosome complex subunit 8

UniProtKB Accession Codes:

Q99627 A8K1H6 Q53QS9

Database IDs:

Citations:

PubMed ID: 7634324

Title: The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms.

PubMed ID: 7634324

DOI: 10.1016/0092-8674(95)90423-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535219

Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

PubMed ID: 9535219

DOI: 10.1096/fasebj.12.6.469

PubMed ID: 11285227

Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.

PubMed ID: 11285227

DOI: 10.1093/emboj/20.7.1630

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12628923

Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

PubMed ID: 12628923

DOI: 10.1093/emboj/cdg127

PubMed ID: 18850735

Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

PubMed ID: 18850735

DOI: 10.1021/pr800574c

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26456823

Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.

PubMed ID: 26456823

DOI: 10.1016/j.celrep.2015.09.021

Sequence Information:

Length: 209
Mass: 23226
Checksum: 203E236D8E304A8A
Sequence:

MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI 
PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL 
VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI 
PLSEPAPVPP IPNEQQLARL TDYVAFLEN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COPS8

Associated with

Other Information

The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. PubMed ID: 7634324

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. PubMed ID: 9535219

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. PubMed ID: 11285227

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. PubMed ID: 11337588

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. PubMed ID: 12732143

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. PubMed ID: 12628923

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. PubMed ID: 18850735

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

CSNAP is a stoichiometric subunit of the COP9 signalosome. PubMed ID: 26456823