Details for: APOBEC2

Gene ID: 10930

Symbol: APOBEC2

Ensembl ID: ENSG00000124701

Description: apolipoprotein B mRNA editing enzyme catalytic subunit 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.67
    Marker Score: 1,273
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,069
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1,382
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.26
    Marker Score: 414
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,813
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,767
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 640
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 386
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.92
    Marker Score: 20,659
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.9
    Marker Score: 1,867
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.86
    Marker Score: 1,406
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.84
    Marker Score: 388
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5,337
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.74
    Marker Score: 660
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.73
    Marker Score: 2,702
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.72
    Marker Score: 323
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.69
    Marker Score: 346
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.68
    Marker Score: 357
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.62
    Marker Score: 3,747
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.51
    Marker Score: 1,797
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 522
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.5
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.46
    Marker Score: 146
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.43
    Marker Score: 669
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.38
    Marker Score: 105
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.36
    Marker Score: 4,839
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.35
    Marker Score: 205
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.33
    Marker Score: 325
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.31
    Marker Score: 428
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 714
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 457
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.28
    Marker Score: 343
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.27
    Marker Score: 61
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.27
    Marker Score: 89
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 461
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.24
    Marker Score: 605
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.24
    Marker Score: 295
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 119
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 430
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2
    Marker Score: 847
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.2
    Marker Score: 189
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.19
    Marker Score: 252
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.19
    Marker Score: 253
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 149
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 144
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.16
    Marker Score: 67
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.16
    Marker Score: 341
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 297
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.15
    Marker Score: 134
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.15
    Marker Score: 433
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 138
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.14
    Marker Score: 411

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOBEC2 is a cytidine deaminase enzyme that belongs to the APOBEC family of enzymes. It is specifically involved in the C-to-U editing process, where it catalyzes the conversion of cytidine to uridine in mRNAs. This editing process is essential for regulating gene expression, as it allows for the fine-tuning of protein production and cell differentiation. APOBEC2 is highly expressed in various cell types, including skeletal muscle cells, colon goblet cells, and granulocytes, suggesting its widespread involvement in immune and non-immune tissues. **Pathways and Functions:** APOBEC2 is involved in several key pathways, including: 1. **Cytidine deamination**: APOBEC2 catalyzes the conversion of cytidine to uridine, which is a critical step in the C-to-U editing process. 2. **Formation of the editosome**: APOBEC2 interacts with other proteins to form the editosome, a complex that assembles at the site of RNA editing. 3. **DNA demethylation**: APOBEC2 has been implicated in the demethylation of DNA, which is essential for maintaining genome stability and regulating gene expression. 4. **Metabolism of RNA**: APOBEC2 plays a role in regulating RNA metabolism, including splicing, editing, and degradation. **Functions:** APOBEC2 has several functions, including: 1. **Regulation of gene expression**: APOBEC2 modulates gene expression by converting cytidine to uridine, which can alter the function of specific mRNAs. 2. **Maintenance of genome stability**: APOBEC2 helps maintain genome stability by demethylating DNA and preventing mutations. 3. **Immune modulation**: APOBEC2 is involved in regulating immune responses, including the editing of mRNAs involved in immune cell function. 4. **Cell differentiation**: APOBEC2 plays a role in cell differentiation, particularly in skeletal muscle cells and enterocytes. **Clinical Significance:** APOBEC2 has been implicated in several diseases, including: 1. **Atherosclerosis**: APOBEC2 has been linked to atherosclerosis, a disease characterized by the buildup of fatty deposits in arteries. 2. **Cancer**: APOBEC2 has been implicated in the development and progression of various cancers, including colorectal cancer. 3. **Immune disorders**: APOBEC2 has been associated with immune disorders, including autoimmune diseases and immunodeficiency disorders. 4. **Neurological disorders**: APOBEC2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, APOBEC2 is a critical component of the RNA editing machinery, playing a vital role in regulating gene expression, maintaining genome stability, and modulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of APOBEC2 in human health and disease. Further research is needed to fully understand the mechanisms of APOBEC2 and its clinical significance.

Genular Protein ID: 900922622

Symbol: ABEC2_HUMAN

Name: C->U-editing enzyme APOBEC-2

UniProtKB Accession Codes:

Q9Y235 B2R899 Q53F28 Q5TGU5 Q5TGU6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10403781

Title: APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family.

PubMed ID: 10403781

DOI: 10.1006/bbrc.1999.0925

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 17187054

Title: The APOBEC-2 crystal structure and functional implications for the deaminase AID.

PubMed ID: 17187054

DOI: 10.1038/nature05492

Sequence Information:

  • Length: 224
  • Mass: 25703
  • Checksum: CA0905AFAA8C8FA1
  • Sequence:
    • MAQKEEAAVA TEAASQNGED LENLDDPEKL KELIELPPFE IVTGERLPAN FFKFQFRNVE 
YSSGRNKTFL CYVVEAQGKG GQVQASRGYL EDEHAAAHAE EAFFNTILPA FDPALRYNVT 
WYVSSSPCAA CADRIIKTLS KTKNLRLLIL VGRLFMWEEP EIQAALKKLK EAGCKLRIMK 
PQDFEYVWQN FVEQEEGESK AFQPWEDIQE NFLYYEEKLA DILK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.