PRDX3 | ENSG00000165672 | NCBI 10935

Details for: PRDX3

Gene ID: 10935

Symbol: PRDX3

Ensembl ID: ENSG00000165672

Description: peroxiredoxin 3

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Alkyl hydroperoxide reductase activity
(GO:0008785)
Cell redox homeostasis
(GO:0045454)
Cellular oxidant detoxification
(GO:0098869)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to stress
(GO:0033554)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Hydrogen peroxide catabolic process
(GO:0042744)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Maternal placenta development
(GO:0001893)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of kinase activity
(GO:0033673)
Nucleoplasm
(GO:0005654)
Peptidyl-cysteine oxidation
(GO:0018171)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of mitochondrial membrane potential
(GO:0051881)
Response to hydrogen peroxide
(GO:0042542)
Response to lipopolysaccharide
(GO:0032496)
Response to oxidative stress
(GO:0006979)
Thioredoxin peroxidase activity
(GO:0008379)

Other Information

Proteins

Thioredoxin-dependent peroxide reductase, mitochondrial

Genular Protein ID: 77132402

Symbol: PRDX3_HUMAN

Name: Thioredoxin-dependent peroxide reductase, mitochondrial

UniProtKB Accession Codes:

P30048 B2R7Z0 D3DRC9 E9PH29 P35690 Q0D2H1 Q13776 Q5T5V2 Q96HK4

Database IDs:

Citations:

PubMed ID: 7733872

Title: Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli.

PubMed ID: 7733872

DOI: 10.1042/bj3070377

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 12059788

Title: A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.

PubMed ID: 12059788

DOI: 10.1042/bj20020525

PubMed ID: 12492477

Title: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.

PubMed ID: 12492477

DOI: 10.1046/j.1432-1033.2003.03363.x

PubMed ID: 15750338

Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.

PubMed ID: 15750338

PubMed ID: 17707404

Title: Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state.

PubMed ID: 17707404

DOI: 10.1016/j.jmb.2007.07.018

PubMed ID: 19462976

Title: Redox potential and peroxide reactivity of human peroxiredoxin 3.

PubMed ID: 19462976

DOI: 10.1021/bi900558g

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21850687

Title: Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

PubMed ID: 21850687

DOI: 10.1002/humu.21582

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27238969

Title: Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state.

PubMed ID: 27238969

DOI: 10.1016/j.str.2016.04.013

PubMed ID: 29438714

Title: Quaternary structure influences the peroxidase activity of peroxiredoxin 3.

PubMed ID: 29438714

DOI: 10.1016/j.bbrc.2018.02.093

PubMed ID: 31782998

Title: Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy: Clinical Evaluation and Identification of the Genetic Basis.

PubMed ID: 31782998

DOI: 10.1016/j.ajo.2019.11.024

PubMed ID: 33889951

Title: Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.

PubMed ID: 33889951

DOI: 10.1093/brain/awab071

PubMed ID: 34369396

Title: Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy.

PubMed ID: 34369396

DOI: 10.1097/ico.0000000000002828

Sequence Information:

Length: 256
Mass: 27693
Checksum: 8BEB7F5E55BFE9BE
Sequence:

MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC 
HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN 
EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG 
LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI 
KPSPAASKEY FQKVNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRDX3

Associated with

Other Information

Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. PubMed ID: 7733872

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human liver protein map: a reference database established by microsequencing and gel comparison. PubMed ID: 1286669

A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. PubMed ID: 12059788

Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. PubMed ID: 12492477

RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. PubMed ID: 15750338

Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state. PubMed ID: 17707404

Redox potential and peroxide reactivity of human peroxiredoxin 3. PubMed ID: 19462976

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. PubMed ID: 20873783

Initial characterization of the human central proteome. PubMed ID: 21269460

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. PubMed ID: 21850687

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state. PubMed ID: 27238969

Quaternary structure influences the peroxidase activity of peroxiredoxin 3. PubMed ID: 29438714

Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy: Clinical Evaluation and Identification of the Genetic Basis. PubMed ID: 31782998

Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia. PubMed ID: 33889951

Confirmation of PRDX3 c.568G&gt;C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy. PubMed ID: 34369396