Details for: PRDX3

Gene ID: 10935

Symbol: PRDX3

Ensembl ID: ENSG00000165672

Description: peroxiredoxin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.56
    Marker Score: 3,713
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.95
    Marker Score: 2,307
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7,598
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.79
    Marker Score: 49,595
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.72
    Marker Score: 1,452
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.63
    Marker Score: 9,343
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.51
    Marker Score: 86,995
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.5
    Marker Score: 4,139
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.45
    Marker Score: 9,431
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.34
    Marker Score: 6,370
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.33
    Marker Score: 5,864
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.32
    Marker Score: 15,093
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.22
    Marker Score: 2,355
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.21
    Marker Score: 16,420
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2
    Marker Score: 8,650
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2
    Marker Score: 22,112
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.19
    Marker Score: 4,583
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.14
    Marker Score: 28,263
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.13
    Marker Score: 1,424
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.12
    Marker Score: 3,268
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.1
    Marker Score: 2,264
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.07
    Marker Score: 8,929
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.07
    Marker Score: 2,924
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.06
    Marker Score: 4,890
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.05
    Marker Score: 2,176
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.03
    Marker Score: 6,026
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.02
    Marker Score: 3,314
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2
    Marker Score: 2,117
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.98
    Marker Score: 17,167
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.97
    Marker Score: 50,556
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.95
    Marker Score: 1,975
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.94
    Marker Score: 22,581
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.94
    Marker Score: 1,067
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.93
    Marker Score: 618
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.92
    Marker Score: 4,530
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.92
    Marker Score: 2,191
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.91
    Marker Score: 4,338
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.89
    Marker Score: 12,109
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.88
    Marker Score: 3,190
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.87
    Marker Score: 776
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.87
    Marker Score: 104,293
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.86
    Marker Score: 8,943
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.83
    Marker Score: 867
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.81
    Marker Score: 675
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.78
    Marker Score: 4,850
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.78
    Marker Score: 3,154
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.78
    Marker Score: 1,791
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.77
    Marker Score: 671
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.77
    Marker Score: 415
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.76
    Marker Score: 877
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.76
    Marker Score: 1,570
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.76
    Marker Score: 508
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.75
    Marker Score: 1,643
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.75
    Marker Score: 2,807
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.74
    Marker Score: 7,127
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.74
    Marker Score: 1,091
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.74
    Marker Score: 1,178
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.73
    Marker Score: 14,930
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.72
    Marker Score: 1,722
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.7
    Marker Score: 2,264
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.7
    Marker Score: 3,315
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.7
    Marker Score: 935
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.69
    Marker Score: 556
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.68
    Marker Score: 1,746
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.68
    Marker Score: 1,792
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.68
    Marker Score: 826
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.67
    Marker Score: 5,251
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.67
    Marker Score: 859
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.66
    Marker Score: 2,452
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.64
    Marker Score: 1,099
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.64
    Marker Score: 4,075
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.64
    Marker Score: 2,316
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.64
    Marker Score: 6,055
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.62
    Marker Score: 1,214
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.61
    Marker Score: 2,567
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.61
    Marker Score: 3,031
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.61
    Marker Score: 9,552
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18,056
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.6
    Marker Score: 3,044
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.59
    Marker Score: 1,499
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.59
    Marker Score: 1,781
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.58
    Marker Score: 3,592
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.58
    Marker Score: 593
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.57
    Marker Score: 541
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.56
    Marker Score: 1,133
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.56
    Marker Score: 2,853
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.56
    Marker Score: 1,136
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.55
    Marker Score: 492
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.53
    Marker Score: 1,788
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.53
    Marker Score: 377
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.52
    Marker Score: 1,618
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.51
    Marker Score: 3,696
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.51
    Marker Score: 631
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.49
    Marker Score: 523
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.49
    Marker Score: 9,488
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.49
    Marker Score: 1,937
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.49
    Marker Score: 607
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.49
    Marker Score: 669
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.48
    Marker Score: 475
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.48
    Marker Score: 2,575

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** PRDX3 is primarily localized to the mitochondrial matrix, where it plays a crucial role in maintaining mitochondrial redox balance. 2. **Thioredoxin-dependent activity:** PRDX3 relies on thioredoxin for its peroxide reductase activity, highlighting the importance of thioredoxin in regulating oxidative stress responses. 3. **Hydrogen peroxide catabolism:** PRDX3 is responsible for the reduction of H2O2 to water, thereby preventing oxidative damage to cellular components. 4. **Regulation of apoptosis:** PRDX3 has been shown to negatively regulate apoptosis, suggesting its role in maintaining cellular survival under stress conditions. 5. **Cellular responses to stimuli:** PRDX3 is involved in regulating cellular responses to various stimuli, including oxidative stress, lipopolysaccharide, and reactive oxygen species. **Pathways and Functions:** 1. **Alkyl hydroperoxide reductase activity:** PRDX3 catalyzes the reduction of alkyl hydroperoxides to their corresponding alcohols. 2. **Cellular redox homeostasis:** PRDX3 maintains the balance of reactive oxygen species (ROS) within cells, preventing oxidative damage and promoting cellular homeostasis. 3. **Cellular responses to stimuli:** PRDX3 regulates cellular responses to various stimuli, including oxidative stress, lipopolysaccharide, and reactive oxygen species. 4. **Mitochondrial membrane potential regulation:** PRDX3 has been shown to regulate mitochondrial membrane potential, which is essential for maintaining cellular energy metabolism. 5. **Apoptosis regulation:** PRDX3 negatively regulates apoptosis, suggesting its role in maintaining cellular survival under stress conditions. **Clinical Significance:** 1. **Oxidative stress disorders:** PRDX3 dysfunction has been implicated in various oxidative stress disorders, including neurodegenerative diseases, cancer, and cardiovascular disease. 2. **Mitochondrial disorders:** PRDX3 mutations have been associated with mitochondrial disorders, including Kearns-Sayre syndrome and MERRF syndrome. 3. **Cancer:** PRDX3 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in cancer progression and metastasis. 4. **Thyroid disorders:** PRDX3 has been implicated in thyroid disorders, including thyroid follicular cell dysfunction and thyroid cancer. 5. **Kidney disease:** PRDX3 has been shown to be involved in kidney disease, including diabetic nephropathy and chronic kidney disease. In conclusion, PRDX3 is a crucial redox regulator that plays a vital role in maintaining cellular homeostasis and responding to oxidative stress. Its dysfunction has been implicated in various diseases, highlighting the importance of PRDX3 in human health and disease. Further research is needed to fully elucidate the mechanisms by which PRDX3 regulates cellular responses to stress and its role in human disease.

Genular Protein ID: 77132402

Symbol: PRDX3_HUMAN

Name: Thioredoxin-dependent peroxide reductase, mitochondrial

UniProtKB Accession Codes:

P30048 B2R7Z0 D3DRC9 E9PH29 P35690 Q0D2H1 Q13776 Q5T5V2 Q96HK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7733872

Title: Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli.

PubMed ID: 7733872

DOI: 10.1042/bj3070377

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 12059788

Title: A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.

PubMed ID: 12059788

DOI: 10.1042/bj20020525

PubMed ID: 12492477

Title: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.

PubMed ID: 12492477

DOI: 10.1046/j.1432-1033.2003.03363.x

PubMed ID: 15750338

Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.

PubMed ID: 15750338

PubMed ID: 17707404

Title: Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state.

PubMed ID: 17707404

DOI: 10.1016/j.jmb.2007.07.018

PubMed ID: 19462976

Title: Redox potential and peroxide reactivity of human peroxiredoxin 3.

PubMed ID: 19462976

DOI: 10.1021/bi900558g

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21850687

Title: Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

PubMed ID: 21850687

DOI: 10.1002/humu.21582

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27238969

Title: Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state.

PubMed ID: 27238969

DOI: 10.1016/j.str.2016.04.013

PubMed ID: 29438714

Title: Quaternary structure influences the peroxidase activity of peroxiredoxin 3.

PubMed ID: 29438714

DOI: 10.1016/j.bbrc.2018.02.093

PubMed ID: 31782998

Title: Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy: Clinical Evaluation and Identification of the Genetic Basis.

PubMed ID: 31782998

DOI: 10.1016/j.ajo.2019.11.024

PubMed ID: 33889951

Title: Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.

PubMed ID: 33889951

DOI: 10.1093/brain/awab071

PubMed ID: 34369396

Title: Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy.

PubMed ID: 34369396

DOI: 10.1097/ico.0000000000002828

Sequence Information:

  • Length: 256
  • Mass: 27693
  • Checksum: 8BEB7F5E55BFE9BE
  • Sequence:
    • MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC 
HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN 
EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG 
LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI 
KPSPAASKEY FQKVNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.