Details for: SEC61B

Gene ID: 10952

Symbol: SEC61B

Ensembl ID: ENSG00000106803

Description: SEC61 translocon subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.67
    Marker Score: 3738
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.11
    Marker Score: 3499
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.63
    Marker Score: 5585.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.52
    Marker Score: 119677
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.48
    Marker Score: 7926
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.39
    Marker Score: 44684
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.37
    Marker Score: 1899
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.34
    Marker Score: 38859
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.3
    Marker Score: 6016
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.29
    Marker Score: 184081
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.26
    Marker Score: 2553
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.24
    Marker Score: 3908
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.18
    Marker Score: 2836
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.16
    Marker Score: 7730
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.14
    Marker Score: 1255
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.14
    Marker Score: 2678
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.12
    Marker Score: 30906
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.08
    Marker Score: 106852.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.08
    Marker Score: 1283
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.07
    Marker Score: 20038
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.06
    Marker Score: 8449
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.04
    Marker Score: 11721
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.96
    Marker Score: 742
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.96
    Marker Score: 3158
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.94
    Marker Score: 9292.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.94
    Marker Score: 22942.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 19012
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.92
    Marker Score: 39238
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.91
    Marker Score: 1694
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.9
    Marker Score: 999
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.9
    Marker Score: 4653
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.87
    Marker Score: 21347
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.85
    Marker Score: 10122
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.84
    Marker Score: 1047.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.79
    Marker Score: 4430
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.77
    Marker Score: 3173
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.76
    Marker Score: 1238
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.76
    Marker Score: 31100
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.76
    Marker Score: 1008
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.75
    Marker Score: 3899
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.74
    Marker Score: 17536
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.74
    Marker Score: 14401
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.74
    Marker Score: 2157
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.73
    Marker Score: 7981
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.73
    Marker Score: 11774
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.72
    Marker Score: 1226
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.7
    Marker Score: 6137
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.69
    Marker Score: 4457
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.69
    Marker Score: 1383
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.68
    Marker Score: 17075
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.67
    Marker Score: 5203
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.67
    Marker Score: 1153
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.67
    Marker Score: 23168
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.66
    Marker Score: 635
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.65
    Marker Score: 1998
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.65
    Marker Score: 2557
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.64
    Marker Score: 847
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.63
    Marker Score: 4946
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.63
    Marker Score: 2061.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.62
    Marker Score: 12848
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4264
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.6
    Marker Score: 10626
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.59
    Marker Score: 6784
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.59
    Marker Score: 1228
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.59
    Marker Score: 66278
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.58
    Marker Score: 11056
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.56
    Marker Score: 6862
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.56
    Marker Score: 1365
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.56
    Marker Score: 15170.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.56
    Marker Score: 1602
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.55
    Marker Score: 4453
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.55
    Marker Score: 2147
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.53
    Marker Score: 6381
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.53
    Marker Score: 1103
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.52
    Marker Score: 6858
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.52
    Marker Score: 1304.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.52
    Marker Score: 1726
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.51
    Marker Score: 2934
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.51
    Marker Score: 1431
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.51
    Marker Score: 1049
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.5
    Marker Score: 1231
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5
    Marker Score: 7411
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.49
    Marker Score: 621
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.49
    Marker Score: 3076
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.49
    Marker Score: 2527
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.49
    Marker Score: 21454
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.48
    Marker Score: 882
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.48
    Marker Score: 2379
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.48
    Marker Score: 2320
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.47
    Marker Score: 621
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.47
    Marker Score: 1553
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.47
    Marker Score: 902
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.47
    Marker Score: 5155.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.47
    Marker Score: 2195
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.46
    Marker Score: 1497
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.46
    Marker Score: 4906
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.45
    Marker Score: 866
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.44
    Marker Score: 3357
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.43
    Marker Score: 6309
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.43
    Marker Score: 2731

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Other Information

**Key Characteristics:** SEC61B is a transmembrane protein subunit of the SEC61 complex, a protein translocation machinery that spans the ER membrane. The SEC61 complex is responsible for the translocation of proteins from the cytosol to the ER lumen, where they can be folded, modified, or secreted. SEC61B, in particular, has been shown to interact with other subunits of the SEC61 complex, such as SEC61A1 and SEC61A2, to facilitate protein translocation. **Pathways and Functions:** SEC61B is involved in several critical cellular and immune-related pathways, including: 1. **Adaptive Immune System:** SEC61B plays a crucial role in the adaptive immune response by facilitating the translocation of antigens from the cytosol to the ER lumen, where they can be processed and presented to T-cells via MHC class I molecules. 2. **Antigen Processing-Cross Presentation:** SEC61B is involved in the cross-presentation of antigens from dendritic cells to T-cells, a process essential for the activation of immune responses against pathogens and tumor cells. 3. **Protein Translocation:** SEC61B regulates the translocation of proteins across the ER membrane, ensuring proper protein folding, modification, and secretion. 4. **ER Quality Control Compartment:** SEC61B is involved in the quality control of proteins in the ER, ensuring that misfolded or aberrant proteins are properly degraded or recycled. **Clinical Significance:** Dysregulation of SEC61B has been implicated in several diseases, including: 1. **Autoimmune Disorders:** Alterations in SEC61B expression or function have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** SEC61B has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumor progression and resistance to therapy. 3. **Neurodegenerative Diseases:** SEC61B has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may play a role in protein misfolding and aggregation. In conclusion, SEC61B is a critical component of the SEC61 complex, playing a vital role in protein translocation and immune function. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding the mechanisms of SEC61B in normal and diseased states. Further research is needed to fully elucidate the functions and dysregulation of SEC61B, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 3909529831

Symbol: SC61B_HUMAN

Name: Protein transport protein Sec61 subunit beta

UniProtKB Accession Codes:

P60468 P38390 P38391 Q6IBC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 20 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 11 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8107851

Title: Evolutionary conservation of components of the protein translocation complex.

PubMed ID: 8107851

DOI: 10.1038/367654a0

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12475939

Title: Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein.

PubMed ID: 12475939

DOI: 10.1091/mbc.e02-04-0198

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19121997

Title: TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein.

PubMed ID: 19121997

DOI: 10.1074/jbc.m807568200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21044946

Title: Site-specific analysis of protein S-acylation by resin-assisted capture.

PubMed ID: 21044946

DOI: 10.1194/jlr.d011106

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28375157

Title: Isolated polycystic liver disease genes define effectors of polycystin-1 function.

PubMed ID: 28375157

DOI: 10.1172/jci90129

PubMed ID: 27044890

Title: Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.

PubMed ID: 27044890

DOI: 10.1083/jcb.201508106

PubMed ID: 32820719

Title: An ER translocon for multi-pass membrane protein biogenesis.

PubMed ID: 32820719

DOI: 10.7554/elife.56889

PubMed ID: 36261522

Title: Substrate-driven assembly of a translocon for multipass membrane proteins.

PubMed ID: 36261522

DOI: 10.1038/s41586-022-05330-8

Sequence Information:

  • Length: 96
  • Mass: 9974
  • Checksum: 5FAFF4197A62FA49
  • Sequence:
    • MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA GTGGMWRFYT 
EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.