Details for: PDIA5

Gene ID: 10954

Symbol: PDIA5

Ensembl ID: ENSG00000065485

Description: protein disulfide isomerase family A member 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.96
    Marker Score: 1,145
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.5
    Marker Score: 14,114
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.47
    Marker Score: 9,477
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,453
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.38
    Marker Score: 7,429
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.37
    Marker Score: 5,933
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.36
    Marker Score: 427
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.18
    Marker Score: 9,071
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.17
    Marker Score: 17,497
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.13
    Marker Score: 11,638
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17,180
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.05
    Marker Score: 1,093
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.05
    Marker Score: 1,831
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.02
    Marker Score: 290
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.02
    Marker Score: 770
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,767
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,991
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Marker Score: 3,871
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.97
    Marker Score: 1,039
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.95
    Marker Score: 396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1,920
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.92
    Marker Score: 2,259
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.91
    Marker Score: 982
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,725
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.9
    Marker Score: 2,041
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.89
    Marker Score: 259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,955
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.86
    Marker Score: 2,809
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 276
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.85
    Marker Score: 404
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.85
    Marker Score: 777
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.83
    Marker Score: 7,896
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.82
    Marker Score: 563
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1,264
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8
    Marker Score: 8,001
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.79
    Marker Score: 184
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.79
    Marker Score: 3,055
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.78
    Marker Score: 946
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.75
    Marker Score: 1,088
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 990
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.74
    Marker Score: 205
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.74
    Marker Score: 1,889
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.74
    Marker Score: 157
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.74
    Marker Score: 187
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4,357
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.72
    Marker Score: 272
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,002
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.71
    Marker Score: 243
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.71
    Marker Score: 171
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.71
    Marker Score: 265
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.7
    Marker Score: 630
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 634
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.67
    Marker Score: 162
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.66
    Marker Score: 1,122
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.66
    Marker Score: 40,443
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.64
    Marker Score: 10,342
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 421
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.63
    Marker Score: 1,012
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.63
    Marker Score: 564
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.62
    Marker Score: 285
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.62
    Marker Score: 2,523
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.61
    Marker Score: 213
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.61
    Marker Score: 160
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.61
    Marker Score: 1,171
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 328
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.59
    Marker Score: 731
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.59
    Marker Score: 3,509
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.59
    Marker Score: 793
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.59
    Marker Score: 3,842
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.59
    Marker Score: 329
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 654
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.58
    Marker Score: 314
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.57
    Marker Score: 778
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.57
    Marker Score: 542
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.56
    Marker Score: 278
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.56
    Marker Score: 2,420
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 336
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.56
    Marker Score: 888
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.55
    Marker Score: 391
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.55
    Marker Score: 2,297
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.55
    Marker Score: 3,515
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.55
    Marker Score: 1,570
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.55
    Marker Score: 687
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.55
    Marker Score: 1,298
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.54
    Marker Score: 379

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDIA5 is a member of the protein disulfide isomerase family, which consists of enzymes that catalyze the formation and rearrangement of disulfide bonds in proteins. PDIA5 exhibits a wide range of cellular expressions, including secondary lens fibers, near-projecting glutamatergic cortical neurons, and centrilobular region hepatocytes. Its expression is also significant in kidney proximal straight tubule epithelial cells, periportal region hepatocytes, midzonal region hepatocytes, kidney capillary endothelial cells, sncg GABAergic cortical interneurons, and lamp5 GABAergic cortical interneurons. **Pathways and Functions:** PDIA5 is involved in several cellular pathways, including: 1. **Electron transport chain (ETC):** PDIA5 is part of the ETC, which generates energy for cellular processes. This pathway is crucial for maintaining cellular homeostasis and responding to stress. 2. **Endoplasmic reticulum (ER) stress response:** PDIA5 is activated in response to ER stress, which is triggered by the accumulation of misfolded proteins. This response is mediated by the unfolded protein response (UPR) and involves the activation of chaperones, such as Ire1α and Xbp1. 3. **Protein folding:** PDIA5 plays a crucial role in protein folding, ensuring that proteins are correctly folded and functional. This process is essential for maintaining cellular homeostasis and preventing protein misfolding. 4. **Oxidoreductase activity:** PDIA5 exhibits oxidoreductase activity, which involves the reduction of oxidized proteins and the formation of disulfide bonds. **Clinical Significance:** PDIA5's involvement in cellular stress response pathways and protein folding makes it an important gene in various diseases. Some potential clinical implications of PDIA5 dysregulation include: 1. **Neurodegenerative diseases:** PDIA5's role in protein folding and cellular stress response may contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** PDIA5's involvement in the unfolded protein response may contribute to cancer development and progression. 3. **Kidney disease:** PDIA5's expression in kidney cells and its role in protein folding may contribute to kidney disease and dysfunction. In conclusion, PDIA5 is a multifaceted gene that plays a crucial role in protein folding, cellular stress response, and the unfolded protein response. Its dysregulation may contribute to various diseases, highlighting the importance of further research into PDIA5's functions and clinical significance.

Genular Protein ID: 2494300778

Symbol: PDIA5_HUMAN

Name: Protein disulfide-isomerase A5

UniProtKB Accession Codes:

Q14554 D3DN95 Q9BV43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556671

Title: Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR).

PubMed ID: 7556671

DOI: 10.1016/0014-5793(95)00996-m

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23614004

Title: Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.

PubMed ID: 23614004

DOI: 10.1371/journal.pone.0062021

Sequence Information:

  • Length: 519
  • Mass: 59594
  • Checksum: 6083FBEB8C019658
  • Sequence:
    • MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL VLYSKSEVAA 
ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD LSPKDKKVEL FHYQDGAFHT 
EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP 
WCSMCKRMMP HFQKAATQLR GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF 
QYDNYGSTAE DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF 
HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS EFPTLKYFKN 
GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL HLVGDNFRET LKKKKHTLVM 
FYAPWCPHCK KVIPHFTATA DAFKDDRKIA CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH 
YGKFAEKYDS DRTELGFTNY IRALREGDHE RLGKKKEEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.