OS9 | ENSG00000135506 | NCBI 10956

Details for: OS9

Gene ID: 10956

Symbol: OS9

Ensembl ID: ENSG00000135506

Description: OS9 endoplasmic reticulum lectin

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Er quality control compartment (erqc)
(R-HSA-901032)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Carbohydrate binding
(GO:0030246)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Erad pathway
(GO:0036503)
Hrd1p ubiquitin ligase complex
(GO:0000836)
Negative regulation of retrograde protein transport, er to cytosol
(GO:1904153)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein retention in er lumen
(GO:0006621)
Protein targeting
(GO:0006605)
Protein ubiquitination
(GO:0016567)
Response to endoplasmic reticulum stress
(GO:0034976)
Retrograde protein transport, er to cytosol
(GO:0030970)
Ubiquitin-dependent protein catabolic process
(GO:0006511)

Other Information

Proteins

Protein OS-9

Genular Protein ID: 3444928569

Symbol: OS9_HUMAN

Name: Protein OS-9

UniProtKB Accession Codes:

Q13438 A6NDD1 A6NFR7 A6NLB2 A8K5Q9 B4DE28 B4DPX1 B4E1I6 E7ENT8 E7EW91 F8VUH2 G3XA88 O00579 Q6IBL2 Q8IZ58 Q9BW99

Database IDs:

Citations:

PubMed ID: 8634085

Title: Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas.

PubMed ID: 8634085

DOI: 10.1002/(sici)1098-2744(199604)15:4<270::aid-mc4>3.0.co;2-k

PubMed ID: 9498564

Title: Genomic organization of the OS-9 gene amplified in human sarcomas.

PubMed ID: 9498564

DOI: 10.1093/oxfordjournals.jbchem.a021880

PubMed ID: 9562620

Title: Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines.

PubMed ID: 9562620

DOI: 10.1093/oxfordjournals.jbchem.a022019

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192850

Title: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

PubMed ID: 9192850

DOI: 10.1006/geno.1997.4727

PubMed ID: 10403379

Title: Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma.

PubMed ID: 10403379

DOI: 10.1016/s0014-5793(99)00700-0

PubMed ID: 17932042

Title: OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.

PubMed ID: 17932042

DOI: 10.1074/jbc.m703903200

PubMed ID: 18417469

Title: A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.

PubMed ID: 18417469

DOI: 10.1074/jbc.m802272200

PubMed ID: 18502753

Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

PubMed ID: 18502753

DOI: 10.1074/jbc.m709336200

PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 19346256

Title: Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.

PubMed ID: 19346256

DOI: 10.1074/jbc.m809725200

PubMed ID: 19084021

Title: Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins.

PubMed ID: 19084021

DOI: 10.1016/j.jmb.2008.11.045

PubMed ID: 20546900

Title: DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.

PubMed ID: 20546900

DOI: 10.1016/j.molimm.2010.04.019

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28827405

Title: Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

PubMed ID: 28827405

DOI: 10.1242/jcs.206847

PubMed ID: 21172656

Title: Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation.

PubMed ID: 21172656

DOI: 10.1016/j.molcel.2010.11.017

Sequence Information:

Length: 667
Mass: 75562
Checksum: 65BA3F66CEC58756
Sequence:

MAAETLLSSL LGLLLLGLLL PASLTGGVGS LNLEELSEMR YGIEILPLPV MGGQSQSSDV 
VIVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE LLSPMRDAPC LLKTKDWWTY 
EFCYGRHIQQ YHMEDSEIKG EVLYLGYYQS AFDWDDETAK ASKQHRLKRY HSQTYGNGSK 
CDLNGRPREA EVRFLCDEGA GISGDYIDRV DEPLSCSYVL TIRTPRLCPH PLLRPPPSAA 
PQAILCHPSL QPEEYMAYVQ RQADSKQYGD KIIEELQDLG PQVWSETKSG VAPQKMAGAS 
PTKDDSKDSD FWKMLNEPED QAPGGEEVPA EEQDPSPEAA DSASGAPNDF QNNVQVKVIR 
SPADLIRFIE ELKGGTKKGK PNIGQEQPVD DAAEVPQREP EKERGDPERQ REMEEEEDED 
EDEDEDEDER QLLGEFEKEL EGILLPSDRD RLRSEVKAGM ERELENIIQE TEKELDPDGL 
KKESERDRAM LALTSTLNKL IKRLEEKQSP ELVKKHKKKR VVPKKPPPSP QPTEEDPEHR 
VRVRVTKLRL GGPNQDLTVL EMKRENPQLK QIEGLVKELL EREGLTAAGK IEIKIVRPWA 
EGTEEGARWL TDEDTRNLKE IFFNILVPGA EEAQKERQRQ KELESNYRRV WGSPGGEGTG 
DLDEFDF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OS9

Associated with

Other Information

Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. PubMed ID: 8634085

Genomic organization of the OS-9 gene amplified in human sarcomas. PubMed ID: 9498564

Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. PubMed ID: 9562620

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. PubMed ID: 9192850

Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. PubMed ID: 10403379

OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. PubMed ID: 17932042

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. PubMed ID: 18417469

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. PubMed ID: 18502753

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. PubMed ID: 18264092

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. PubMed ID: 19346256

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. PubMed ID: 19084021

DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. PubMed ID: 20546900

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). PubMed ID: 28827405

Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. PubMed ID: 21172656