TMED2 | ENSG00000086598 | NCBI 10959

Details for: TMED2

Gene ID: 10959

Symbol: TMED2

Ensembl ID: ENSG00000086598

Description: transmembrane p24 trafficking protein 2

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch processing in golgi
(R-HSA-1912420)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Allantois development
(GO:1905069)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Cargo receptor activity
(GO:0038024)
Chorion development
(GO:0060717)
Copi-coated vesicle
(GO:0030137)
Copi-coated vesicle membrane
(GO:0030663)
Copi coating of golgi vesicle
(GO:0048205)
Copii-coated er to golgi transport vesicle
(GO:0030134)
Copii vesicle coating
(GO:0048208)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum membrane organization
(GO:0090158)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Er to golgi transport vesicle membrane
(GO:0012507)
Frizzled binding
(GO:0005109)
Golgi apparatus
(GO:0005794)
Golgi cisterna membrane
(GO:0032580)
Golgi membrane
(GO:0000139)
Golgi organization
(GO:0007030)
Heart looping
(GO:0001947)
Inflammatory response
(GO:0006954)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular protein transport
(GO:0006886)
Labyrinthine layer blood vessel development
(GO:0060716)
Maintenance of protein localization in organelle
(GO:0072595)
Maternal placenta development
(GO:0001893)
Membrane
(GO:0016020)
Multicellular organism growth
(GO:0035264)
Negative regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation
(GO:1903912)
Negative regulation of gtpase activity
(GO:0034260)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Neural tube closure
(GO:0001843)
Perk-mediated unfolded protein response
(GO:0036499)
Positive regulation of gene expression
(GO:0010628)
Post-anal tail morphogenesis
(GO:0036342)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein secretion
(GO:0009306)
Regulation of srebp signaling pathway
(GO:2000638)
Smoothened binding
(GO:0005119)
Somite rostral/caudal axis specification
(GO:0032525)
Transport vesicle
(GO:0030133)
Vesicle cargo loading
(GO:0035459)
Zymogen granule membrane
(GO:0042589)

Other Information

Proteins

Transmembrane emp24 domain-containing protein 2

Genular Protein ID: 2281080397

Symbol: TMED2_HUMAN

Name: Transmembrane emp24 domain-containing protein 2

UniProtKB Accession Codes:

Q15363

Database IDs:

Citations:

PubMed ID: 8663407

Title: Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.

PubMed ID: 8663407

DOI: 10.1074/jbc.271.29.17183

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9472029

Title: gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.

PubMed ID: 9472029

DOI: 10.1083/jcb.140.4.751

PubMed ID: 10359607

Title: Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.

PubMed ID: 10359607

DOI: 10.1091/mbc.10.6.1939

PubMed ID: 10761932

Title: Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex.

PubMed ID: 10761932

DOI: 10.1016/s0092-8674(00)80703-5

PubMed ID: 10852829

Title: Coupled transport of p24 family members.

PubMed ID: 10852829

DOI: 10.1242/jcs.113.13.2507

PubMed ID: 12237308

Title: Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.

PubMed ID: 12237308

DOI: 10.1074/jbc.m206989200

PubMed ID: 16940185

Title: Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.

PubMed ID: 16940185

DOI: 10.1128/mcb.01055-06

PubMed ID: 17693410

Title: p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.

PubMed ID: 17693410

DOI: 10.1074/jbc.m703205200

PubMed ID: 17321752

Title: Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis.

PubMed ID: 17321752

DOI: 10.1016/j.mcn.2007.01.012

PubMed ID: 18287528

Title: The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.

PubMed ID: 18287528

DOI: 10.1091/mbc.e07-10-0989

PubMed ID: 20361938

Title: The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway.

PubMed ID: 20361938

DOI: 10.1016/j.bbrc.2010.03.156

PubMed ID: 20427317

Title: Selective export of human GPI-anchored proteins from the endoplasmic reticulum.

PubMed ID: 20427317

DOI: 10.1242/jcs.062950

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21219331

Title: Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

PubMed ID: 21219331

DOI: 10.1111/j.1471-4159.2011.07173.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27569046

Title: 3D structure and interaction of p24beta and p24delta golgi dynamics domains: implication for p24 complex formation and cargo transport.

PubMed ID: 27569046

DOI: 10.1016/j.jmb.2016.08.023

Sequence Information:

Length: 201
Mass: 22761
Checksum: C452370E459DC894
Sequence:

MVTLAELLVL LAALLATVSG YFVSIDAHAE ECFFERVTSG TKMGLIFEVA EGGFLDIDVE 
ITGPDNKGIY KGDRESSGKY TFAAHMDGTY KFCFSNRMST MTPKIVMFTI DIGEAPKGQD 
METEAHQNKL EEMINELAVA MTAVKHEQEY MEVRERIHRA INDNTNSRVV LWSFFEALVL 
VAMTLGQIYY LKRFFEVRRV V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TMED2

Associated with

Other Information

Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. PubMed ID: 8663407

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. PubMed ID: 9472029

Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. PubMed ID: 10359607

Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. PubMed ID: 10761932

Coupled transport of p24 family members. PubMed ID: 10852829

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. PubMed ID: 12237308

Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. PubMed ID: 16940185

p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. PubMed ID: 17693410

Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis. PubMed ID: 17321752

The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. PubMed ID: 18287528

The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway. PubMed ID: 20361938

Selective export of human GPI-anchored proteins from the endoplasmic reticulum. PubMed ID: 20427317

Initial characterization of the human central proteome. PubMed ID: 21269460

Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. PubMed ID: 21219331

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

3D structure and interaction of p24beta and p24delta golgi dynamics domains: implication for p24 complex formation and cargo transport. PubMed ID: 27569046