ACOT2 | ENSG00000119673 | NCBI 10965

Details for: ACOT2

Gene ID: 10965

Symbol: ACOT2

Ensembl ID: ENSG00000119673

Description: acyl-CoA thioesterase 2

Associated with

Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial fatty acid beta-oxidation
(R-HSA-77289)
Mitochondrial protein degradation
(R-HSA-9837999)
Peroxisomal protein import
(R-HSA-9033241)
Protein localization
(R-HSA-9609507)
Acyl-coa metabolic process
(GO:0006637)
Carboxylic ester hydrolase activity
(GO:0052689)
Cytosol
(GO:0005829)
Fatty acid metabolic process
(GO:0006631)
Fatty acyl-coa hydrolase activity
(GO:0047617)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acyl-coa hydrolase activity
(GO:0052816)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Peroxisomal matrix
(GO:0005782)
Protein binding
(GO:0005515)
Very long-chain fatty acid metabolic process
(GO:0000038)

Other Information

Proteins

Acyl-coenzyme A thioesterase 2, mitochondrial

Genular Protein ID: 2638538941

Symbol: ACOT2_HUMAN

Name: Acyl-coenzyme A thioesterase 2, mitochondrial

UniProtKB Accession Codes:

P49753 Q3I5F8 Q53EK4 Q9NUX4

Database IDs:

Citations:

PubMed ID: 7596406

Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

PubMed ID: 7596406

DOI: 10.1038/375754a0

PubMed ID: 16940157

Title: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.

PubMed ID: 16940157

DOI: 10.1096/fj.06-6042com

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10944470

Title: Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.

PubMed ID: 10944470

DOI: 10.1006/bbrc.2000.3285

PubMed ID: 19497300

Title: Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2).

PubMed ID: 19497300

DOI: 10.1016/j.bbrc.2009.05.122

Sequence Information:

Length: 483
Mass: 53218
Checksum: FAEDD42BBBD935E4
Sequence:

MSNKLLSPHP HSVVLRSEFK MASSPAVLRA SRLYQWSLKS SAQFLGSPQL RQVGQIIRVP 
ARMAATLILE PAGRCCWDEP VRIAVRGLAP EQPVTLRASL RDEKGALFQA HARYRADTLG 
ELDLERAPAL GGSFAGLEPM GLLWALEPEK PLVRLVKRDV RTPLAVELEV LDGHDPDPGR 
LLCQTRHERY FLPPGVRREP VRVGRVRGTL FLPPEPGPFP GIVDMFGTGG GLLEYRASLL 
AGKGFAVMAL AYYNYEDLPK TMETLHLEYF EEAMNYLLSH PEVKGPGVGL LGISKGGELC 
LSMASFLKGI TAAVVINGSV ANVGGTLHYK GETLPPVGVN RNRIKVTKDG YADIVDVLNS 
PLEGPDQKSF IPVERAESTF LFLVGQDDHN WKSEFYANEA CKRLQAHGRR KPQIICYPET 
GHYIEPPYFP LCRASLHALV GSPIIWGGEP RAHAMAQVDA WKQLQTFFHK HLGGHEGTIP 
SKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACOT2

Associated with

Other Information

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. PubMed ID: 7596406

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. PubMed ID: 16940157

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. PubMed ID: 10944470