Details for: CLP1

Gene ID: 10978

Symbol: CLP1

Ensembl ID: ENSG00000172409

Description: cleavage factor polyribonucleotide kinase subunit 1

Associated with

Other Information

Genular Protein ID: 3061014629

Symbol: CLP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92989 B2R7J6 B4DTI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8896421

Title: AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).

PubMed ID: 8896421

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11060040

Title: Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.

PubMed ID: 11060040

DOI: 10.1093/emboj/19.21.5895

PubMed ID: 15109492

Title: Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.

PubMed ID: 15109492

DOI: 10.1016/s0092-8674(04)00342-3

PubMed ID: 17495927

Title: The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.

PubMed ID: 17495927

DOI: 10.1038/nature05777

PubMed ID: 18648070

Title: Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo.

PubMed ID: 18648070

DOI: 10.1261/rna.1142908

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24766809

Title: Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

PubMed ID: 24766809

DOI: 10.1016/j.cell.2014.02.058

PubMed ID: 24766810

Title: CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.

PubMed ID: 24766810

DOI: 10.1016/j.cell.2014.03.049

Sequence Information:

  • Length: 425
  • Mass: 47646
  • Checksum: 640AF4768994CFE6
  • Sequence:
    • MGEEANDDKK PTTKFELERE TELRFEVEAS QSVQLELLTG MAEIFGTELT RNKKFTFDAG 
AKVAVFTWHG CSVQLSGRTE VAYVSKDTPM LLYLNTHTAL EQMRRQAEKE EERGPRVMVV 
GPTDVGKSTV CRLLLNYAVR LGRRPTYVEL DVGQGSVSIP GTMGALYIER PADVEEGFSI 
QAPLVYHFGS TTPGTNIKLY NKITSRLADV FNQRCEVNRR ASVSGCVINT CGWVKGSGYQ 
ALVHAASAFE VDVVVVLDQE RLYNELKRDL PHFVRTVLLP KSGGVVERSK DFRRECRDER 
IREYFYGFRG CFYPHAFNVK FSDVKIYKVG APTIPDSCLP LGMSQEDNQL KLVPVTPGRD 
MVHHLLSVST AEGTEENLSE TSVAGFIVVT SVDLEHQVFT VLSPAPRPLP KNFLLIMDIR 
FMDLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.