FERMT2 | ENSG00000073712 | NCBI 10979

Details for: FERMT2

Gene ID: 10979

Symbol: FERMT2

Ensembl ID: ENSG00000073712

Description: FERM domain containing kindlin 2

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell-extracellular matrix interactions
(R-HSA-446353)
Cell junction organization
(R-HSA-446728)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac3 gtpase cycle
(R-HSA-9013423)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin binding
(GO:0003779)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Adherens junction maintenance
(GO:0034334)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell cortex
(GO:0005938)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Focal adhesion
(GO:0005925)
Focal adhesion assembly
(GO:0048041)
I band
(GO:0031674)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin activation
(GO:0033622)
Integrin binding
(GO:0005178)
Lamellipodium membrane
(GO:0031258)
Limb development
(GO:0060173)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of vascular permeability
(GO:0043116)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of integrin activation
(GO:0033625)
Positive regulation of mesenchymal stem cell proliferation
(GO:1902462)
Positive regulation of myosin light chain kinase activity
(GO:0035505)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Positive regulation of wound healing, spreading of epidermal cells
(GO:1903691)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to cell junction
(GO:1902414)
Protein localization to membrane
(GO:0072657)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of cell shape
(GO:0008360)
Smad binding
(GO:0046332)
Stress fiber
(GO:0001725)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Fermitin family homolog 2

Genular Protein ID: 3632927190

Symbol: FERM2_HUMAN

Name: Fermitin family homolog 2

UniProtKB Accession Codes:

Q96AC1 B5TJY2 Q14840 Q86TY7

Database IDs:

Citations:

PubMed ID: 8175911

Title: Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression.

PubMed ID: 8175911

DOI: 10.1242/jcs.107.1.227

PubMed ID: 12697302

Title: URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.

PubMed ID: 12697302

DOI: 10.1016/s0925-4439(03)00035-8

PubMed ID: 12679033

Title: Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.

PubMed ID: 12679033

DOI: 10.1016/s0092-8674(03)00163-6

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18458155

Title: Kindlin-2 (Mig-2): a co-activator of beta3 integrins.

PubMed ID: 18458155

DOI: 10.1083/jcb.200710196

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21768292

Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.

PubMed ID: 21768292

DOI: 10.1083/jcb.201007108

PubMed ID: 21325030

Title: Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins.

PubMed ID: 21325030

DOI: 10.1242/jcs.076976

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22699938

Title: Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling.

PubMed ID: 22699938

DOI: 10.1038/embor.2012.88

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22030399

Title: Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.

PubMed ID: 22030399

DOI: 10.1074/jbc.m111.295352

PubMed ID: 22078565

Title: Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation.

PubMed ID: 22078565

DOI: 10.1016/j.str.2011.08.012

PubMed ID: 22653426

Title: Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation.

PubMed ID: 22653426

DOI: 10.1007/s13238-012-2046-1

Sequence Information:

Length: 680
Mass: 77861
Checksum: BAFF5AF2CD91C43C
Sequence:

MALDGIRMPD GCYADGTWEL SVHVTDLNRD VTLRVTGEVH IGGVMLKLVE KLDVKKDWSD 
HALWWEKKRT WLLKTHWTLD KYGIQADAKL QFTPQHKLLR LQLPNMKYVK VKVNFSDRVF 
KAVSDICKTF NIRHPEELSL LKKPRDPTKK KKKKLDDQSE DEALELEGPL ITPGSGSIYS 
SPGLYSKTMT PTYDAHDGSP LSPTSAWFGD SALSEGNPGI LAVSQPITSP EILAKMFKPQ 
ALLDKAKINQ GWLDSSRSLM EQDVKENEAL LLRFKYYSFF DLNPKYDAIR INQLYEQAKW 
AILLEEIECT EEEMMMFAAL QYHINKLSIM TSENHLNNSD KEVDEVDAAL SDLEITLEGG 
KTSTILGDIT SIPELADYIK VFKPKKLTLK GYKQYWCTFK DTSISCYKSK EESSGTPAHQ 
MNLRGCEVTP DVNISGQKFN IKLLIPVAEG MNEIWLRCDN EKQYAHWMAA CRLASKGKTM 
ADSSYNLEVQ NILSFLKMQH LNPDPQLIPE QITTDITPEC LVSPRYLKKY KNKQITARIL 
EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG KKEELIGIAY NRLIRMDAST 
GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE VDCKVVHEFI GGYIFLSTRA 
KDQNESLDEE MFYKLTSGWV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FERMT2

Associated with

Other Information

Identification of serum-inducible genes: different patterns of gene regulation during G0-&gt;S and G1-&gt;S progression. PubMed ID: 8175911

URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. PubMed ID: 12697302

Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. PubMed ID: 12679033

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Kindlin-2 (Mig-2): a co-activator of beta3 integrins. PubMed ID: 18458155

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. PubMed ID: 21768292

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. PubMed ID: 21325030

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling. PubMed ID: 22699938

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. PubMed ID: 22030399

Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation. PubMed ID: 22078565

Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation. PubMed ID: 22653426