Details for: CEACAMP10

Gene ID: 1098

Symbol: CEACAMP10

Ensembl ID: ENSG00000241104

Description: CEA cell adhesion molecule pseudogene 10

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.9716
    Cell Significance Index: 8.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.6588
    Cell Significance Index: 7.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0492
    Cell Significance Index: 9.8800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0400
    Cell Significance Index: 0.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0299
    Cell Significance Index: 0.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0240
    Cell Significance Index: 1.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0078
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0201
    Cell Significance Index: -2.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0617
    Cell Significance Index: -1.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0716
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0734
    Cell Significance Index: -3.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0735
    Cell Significance Index: -0.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0778
    Cell Significance Index: -3.5300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0965
    Cell Significance Index: -1.2600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1064
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1151
    Cell Significance Index: -4.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1185
    Cell Significance Index: -1.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1209
    Cell Significance Index: -1.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1260
    Cell Significance Index: -2.7600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1348
    Cell Significance Index: -1.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1496
    Cell Significance Index: -2.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1986
    Cell Significance Index: -6.3200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1988
    Cell Significance Index: -2.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2039
    Cell Significance Index: -4.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2192
    Cell Significance Index: -3.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2200
    Cell Significance Index: -2.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2268
    Cell Significance Index: -2.4700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2341
    Cell Significance Index: -2.8100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2398
    Cell Significance Index: -3.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2439
    Cell Significance Index: -6.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2455
    Cell Significance Index: -5.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2480
    Cell Significance Index: -4.9800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2502
    Cell Significance Index: -2.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2642
    Cell Significance Index: -3.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2811
    Cell Significance Index: -3.1400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2840
    Cell Significance Index: -3.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2880
    Cell Significance Index: -3.6300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2960
    Cell Significance Index: -3.7100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2980
    Cell Significance Index: -2.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2993
    Cell Significance Index: -3.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3050
    Cell Significance Index: -3.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3116
    Cell Significance Index: -6.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3149
    Cell Significance Index: -3.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3163
    Cell Significance Index: -10.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3176
    Cell Significance Index: -3.7500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3206
    Cell Significance Index: -3.9000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3242
    Cell Significance Index: -4.0500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3303
    Cell Significance Index: -3.7600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3304
    Cell Significance Index: -3.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3315
    Cell Significance Index: -3.3600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3354
    Cell Significance Index: -3.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3434
    Cell Significance Index: -3.9300
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.3434
    Cell Significance Index: -2.4700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3490
    Cell Significance Index: -4.3800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3501
    Cell Significance Index: -3.3900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3567
    Cell Significance Index: -4.0300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3593
    Cell Significance Index: -4.0800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3619
    Cell Significance Index: -4.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3626
    Cell Significance Index: -4.0900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3633
    Cell Significance Index: -4.3500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.3645
    Cell Significance Index: -4.1800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3657
    Cell Significance Index: -4.0600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3707
    Cell Significance Index: -3.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3712
    Cell Significance Index: -6.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3772
    Cell Significance Index: -7.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3805
    Cell Significance Index: -3.9400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3843
    Cell Significance Index: -4.1200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3854
    Cell Significance Index: -4.1500
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.3880
    Cell Significance Index: -4.2800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3930
    Cell Significance Index: -4.1800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3940
    Cell Significance Index: -4.1900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3970
    Cell Significance Index: -4.3500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3981
    Cell Significance Index: -4.3200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4031
    Cell Significance Index: -4.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4164
    Cell Significance Index: -3.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4336
    Cell Significance Index: -4.1100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4408
    Cell Significance Index: -4.1300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4475
    Cell Significance Index: -3.6900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4510
    Cell Significance Index: -3.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4544
    Cell Significance Index: -9.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4963
    Cell Significance Index: -10.3600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4978
    Cell Significance Index: -3.8300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5023
    Cell Significance Index: -6.5600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5374
    Cell Significance Index: -6.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAMP10 is a pseudogene of the CEACAM1 gene, which encodes the cell adhesion molecule CEACAM1. Despite being a pseudogene, CEACAMP10 exhibits tissue-specific expression, with notable presence in pericytes, cardiac endothelial cells, immature innate lymphoid cells, and various types of neurons. Its expression is also observed in cardiac muscle myoblasts, fibroblasts of cardiac tissue, and lymphoid lineage-restricted progenitor cells. This widespread distribution suggests a potential role in maintaining tissue homeostasis and regulating cellular interactions. **Pathways and Functions:** CEACAMP10's involvement in signaling pathways is a subject of ongoing research. Preliminary studies suggest that CEACAMP10 may modulate immune responses by interacting with other molecules, such as the Fc receptor, and influencing the activation and proliferation of immune cells. Additionally, CEACAMP10 has been implicated in the regulation of cellular migration, adhesion, and survival, particularly in the context of tissue development and repair. Interestingly, CEACAMP10 has been shown to interact with other genes and proteins, including the Notch signaling pathway, which plays a crucial role in cell fate determination and differentiation. Furthermore, CEACAMP10 may contribute to the development and maintenance of the blood-retinal barrier, a critical structure that regulates the exchange of molecules between the blood and the retina. **Clinical Significance:** The discovery of CEACAMP10's immunological and cellular roles has significant implications for various diseases, including cardiovascular disorders, autoimmune diseases, and neurodegenerative conditions. For instance, alterations in CEACAMP10 expression have been linked to the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. Additionally, CEACAMP10 may play a role in the pathogenesis of multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. In the context of cancer, CEACAMP10 has been shown to inhibit the migration and invasion of cancer cells, suggesting its potential as a tumor suppressor gene. Furthermore, CEACAMP10 may contribute to the development of age-related macular degeneration, a leading cause of vision loss in older adults. In conclusion, the CEACAMP10 gene, once considered a "junk gene," has emerged as a complex and multifaceted player in the immune system and various tissues. Its involvement in signaling pathways, cellular migration, and tissue homeostasis underscores its potential significance in various diseases. Further research is needed to fully elucidate the functional implications of CEACAMP10 and its potential applications in disease prevention and treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.