Details for: COPS6

Gene ID: 10980

Symbol: COPS6

Ensembl ID: ENSG00000168090

Description: COP9 signalosome subunit 6

Associated with

Other Information

Genular Protein ID: 665223412

Symbol: CSN6_HUMAN

Name: COP9 signalosome complex subunit 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9341143

Title: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.

PubMed ID: 9341143

DOI: 10.1074/jbc.272.43.27042

PubMed ID: 9535219

Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

PubMed ID: 9535219

DOI: 10.1096/fasebj.12.6.469

PubMed ID: 8195203

Title: Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.

PubMed ID: 8195203

DOI: 10.1016/s0021-9258(17)40719-8

PubMed ID: 9520381

Title: HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.

PubMed ID: 9520381

DOI: 10.1073/pnas.95.7.3419

PubMed ID: 11285227

Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.

PubMed ID: 11285227

DOI: 10.1093/emboj/20.7.1630

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12220626

Title: Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.

PubMed ID: 12220626

DOI: 10.1016/s0014-5793(02)03147-2

PubMed ID: 12237292

Title: Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling.

PubMed ID: 12237292

DOI: 10.1074/jbc.m203905200

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12628923

Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

PubMed ID: 12628923

DOI: 10.1093/emboj/cdg127

PubMed ID: 18850735

Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

PubMed ID: 18850735

DOI: 10.1021/pr800574c

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21625211

Title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma.

PubMed ID: 21625211

DOI: 10.1038/onc.2011.192

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26456823

Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.

PubMed ID: 26456823

DOI: 10.1016/j.celrep.2015.09.021

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

Sequence Information:

  • Length: 327
  • Mass: 36163
  • Checksum: E33CAC6ADF799A8D
  • Sequence:
  • MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS 
    QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE 
    FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT 
    MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE 
    YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN 
    TMNQFVNKFN VLYDRQGIGR RMRGLFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.