Details for: RAB32

Gene ID: 10981

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RAB32

Ensembl ID: ENSG00000118508

Description: RAB32, member RAS oncogene family

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • granulocyte monocyte progenitor cell CL0000557
    CSI 43.53
    rCSI 37.69%
    PRS 88.77
  • promyelocyte CL0000836
    CSI 31.21
    rCSI 45.02%
    PRS 89.66
  • common myeloid progenitor CL0000049
    CSI 30.17
    rCSI 24.4%
    PRS 87.59
  • melanocyte CL0000148
    CSI 26.98
    rCSI 19.98%
    PRS 80.66
  • myeloid leukocyte CL0000766
    CSI 24.19
    rCSI 22.32%
    PRS 86.94
  • promonocyte CL0000559
    CSI 18.34
    rCSI 31.42%
    PRS 89.68
  • conventional dendritic cell CL0000990
    CSI 16.78
    rCSI 14.01%
    PRS 82.86
  • Hofbauer cell CL3000001
    CSI 14.21
    rCSI 26.82%
    PRS 91.97
  • pancreatic ductal cell CL0002079
    CSI 12.92
    rCSI 25.13%
    PRS 88.29
  • Langerhans cell CL0000453
    CSI 12.45
    rCSI 19.01%
    PRS 93.93
  • colonocyte CL1000347
    CSI 8.49
    rCSI 12.17%
    PRS 85.06
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 7.34
    rCSI 9.61%
    PRS 93.7
  • megakaryocyte CL0000556
    CSI 6.8
    rCSI 29.48%
    PRS 88.87
  • group 3 innate lymphoid cell CL0001071
    CSI 6.13
    rCSI 4.61%
    PRS 90.29
  • platelet CL0000233
    CSI 5.97
    rCSI 24.78%
    PRS 82.55
  • elicited macrophage CL0000861
    CSI 5.86
    rCSI 5.38%
    PRS 91.86
  • non-classical monocyte CL0000875
    CSI 5.31
    rCSI 8.51%
    PRS 92.52
  • pancreatic acinar cell CL0002064
    CSI 4.8
    rCSI 6.38%
    PRS 89.96
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 4.76
    rCSI 3.67%
    PRS 88.99
  • endothelial cell of lymphatic vessel CL0002138
    CSI 4.73
    rCSI 9.37%
    PRS 88.78
  • respiratory basal cell CL0002633
    CSI 4.7
    rCSI 4.87%
    PRS 88.56
  • epithelial cell of lower respiratory tract CL0002632
    CSI 4.66
    rCSI 3.61%
    PRS 89.06
  • pancreatic stellate cell CL0002410
    CSI 4.54
    rCSI 26.42%
    PRS 88.13
  • hepatocyte CL0000182
    CSI 4.43
    rCSI 7.93%
    PRS 84.91
  • macrophage CL0000235
    CSI 4.36
    rCSI 7.93%
    PRS 88.79
  • colon epithelial cell CL0011108
    CSI 4.2
    rCSI 4.4%
    PRS 83.26
  • mesenchymal cell CL0008019
    CSI 4.09
    rCSI 10.38%
    PRS 79.68
  • enteroendocrine cell CL0000164
    CSI 3.92
    rCSI 5.36%
    PRS 84.77
  • CD14-positive monocyte CL0001054
    CSI 3.92
    rCSI 4.88%
    PRS 92.86
  • acinar cell CL0000622
    CSI 3.74
    rCSI 5.49%
    PRS 92.86
  • dendritic cell CL0000451
    CSI 3.67
    rCSI 4.52%
    PRS 86.96
  • granulocyte CL0000094
    CSI 3.58
    rCSI 5.47%
    PRS 91.26
  • alveolar macrophage CL0000583
    CSI 3.56
    rCSI 5.86%
    PRS 88.84
  • myoepithelial cell CL0000185
    CSI 3.53
    rCSI 8.94%
    PRS 89.27
  • pancreatic D cell CL0000173
    CSI 3.52
    rCSI 3.46%
    PRS 87.65
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 3.51
    rCSI 3.17%
    PRS 84.31
  • glioblast CL0000030
    CSI 3.5
    rCSI 5.58%
    PRS 77.79
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.45
    rCSI 6.52%
    PRS 92.83
  • mononuclear phagocyte CL0000113
    CSI 3.39
    rCSI 7.46%
    PRS 88.75
  • radial glial cell CL0000681
    CSI 3.36
    rCSI 4.67%
    PRS 84.15
  • neural crest cell CL0011012
    CSI 3.35
    rCSI 2.65%
    PRS 76.64
  • enterocyte CL0000584
    CSI 3.31
    rCSI 5.34%
    PRS 83.5
  • monocyte CL0000576
    CSI 3.31
    rCSI 5.98%
    PRS 88.54
  • inflammatory macrophage CL0000863
    CSI 3.29
    rCSI 5.63%
    PRS 95.78
  • hematopoietic stem cell CL0000037
    CSI 3.29
    rCSI 2.19%
    PRS 87.67
  • bronchus fibroblast of lung CL2000093
    CSI 3.17
    rCSI 2.58%
    PRS 85.23
  • perivascular cell CL4033054
    CSI 3.16
    rCSI 4.32%
    PRS 89.59
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 3.12
    rCSI 18.87%
    PRS 93.5
  • intrahepatic cholangiocyte CL0002538
    CSI 3.1
    rCSI 7.44%
    PRS 87.77
  • alveolar adventitial fibroblast CL4028006
    CSI 3.08
    rCSI 4.86%
    PRS 86.91
  • mast cell CL0000097
    CSI 3.08
    rCSI 6.64%
    PRS 86.94
  • M cell of gut CL0000682
    CSI 2.94
    rCSI 3.13%
    PRS 88.99
  • lung ciliated cell CL1000271
    CSI 2.88
    rCSI 3.33%
    PRS 79.25
  • stem cell CL0000034
    CSI 2.85
    rCSI 2.75%
    PRS 80.64
  • alternatively activated macrophage CL0000890
    CSI 2.81
    rCSI 3.53%
    PRS 92.73
  • Kupffer cell CL0000091
    CSI 2.78
    rCSI 6.36%
    PRS 86.74
  • blood vessel endothelial cell CL0000071
    CSI 2.77
    rCSI 5.75%
    PRS 83.24
  • skin fibroblast CL0002620
    CSI 2.68
    rCSI 2.31%
    PRS 85.45
  • interstitial cell of Cajal CL0002088
    CSI 2.65
    rCSI 3.37%
    PRS 89.98
  • early lymphoid progenitor CL0000936
    CSI 2.54
    rCSI 2.23%
    PRS 89.68
  • intestine goblet cell CL0019031
    CSI 2.48
    rCSI 2.2%
    PRS 83.28
  • club cell CL0000158
    CSI 2.44
    rCSI 3.58%
    PRS 80.82
  • basal cell CL0000646
    CSI 2.43
    rCSI 3.24%
    PRS 83.48
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.42
    rCSI 2.65%
    PRS 87.45
  • intestinal epithelial cell CL0002563
    CSI 2.4
    rCSI 2.51%
    PRS 83.21
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 2.34
    rCSI 2.83%
    PRS 91.98
  • mesodermal cell CL0000222
    CSI 2.33
    rCSI 2.79%
    PRS 84.02
  • adventitial cell CL0002503
    CSI 2.31
    rCSI 5.51%
    PRS 88.62
  • intermediate monocyte CL0002393
    CSI 2.3
    rCSI 3.47%
    PRS 90.41
  • epithelial cell of lung CL0000082
    CSI 2.3
    rCSI 1.9%
    PRS 86.79
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.25
    rCSI 2.16%
    PRS 84.89
  • common dendritic progenitor CL0001029
    CSI 2.19
    rCSI 2.75%
    PRS 92.22
  • lung macrophage CL1001603
    CSI 2.09
    rCSI 4.66%
    PRS 91.46
  • lung secretory cell CL1000272
    CSI 2.07
    rCSI 5.12%
    PRS 86.19
  • cerebral cortex endothelial cell CL1001602
    CSI 2.07
    rCSI 3.57%
    PRS 78.84
  • BEST4+ enteroycte CL4030026
    CSI 2.05
    rCSI 2.54%
    PRS 86.06
  • enteric smooth muscle cell CL0002504
    CSI 2.02
    rCSI 2.88%
    PRS 86.29
  • eosinophil CL0000771
    CSI 1.98
    rCSI 13%
    PRS 95.88
  • myeloid dendritic cell CL0000782
    CSI 1.89
    rCSI 2.74%
    PRS 95.16
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.86
    rCSI 3.38%
    PRS 92.79
  • transit amplifying cell of colon CL0009011
    CSI 1.82
    rCSI 2.14%
    PRS 86.7
  • transit amplifying cell CL0009010
    CSI 1.81
    rCSI 2.76%
    PRS 90.99
  • mucous neck cell CL0000651
    CSI 1.77
    rCSI 2.55%
    PRS 90.18
  • colon macrophage CL0009038
    CSI 1.76
    rCSI 8.14%
    PRS 94.5
  • kidney epithelial cell CL0002518
    CSI 1.74
    rCSI 3.32%
    PRS 94.99
  • dendritic cell, human CL0001056
    CSI 1.63
    rCSI 2.51%
    PRS 92.39
  • intestinal crypt stem cell of colon CL0009043
    CSI 1.62
    rCSI 12.14%
    PRS 92.36
  • respiratory suprabasal cell CL4033048
    CSI 1.57
    rCSI 2.02%
    PRS 88.28
  • basophil CL0000767
    CSI 1.39
    rCSI 2.93%
    PRS 93.29
  • basal cell of prostate epithelium CL0002341
    CSI 1.35
    rCSI 3.92%
    PRS 90.02
  • mammary gland epithelial cell CL0002327
    CSI 1.13
    rCSI 3.96%
    PRS 91.34
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.08
    rCSI 2.59%
    PRS 94.89
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 1.07
    rCSI 5.51%
    PRS 95.8
  • myeloid dendritic cell, human CL0001057
    CSI 1.06
    rCSI 5.94%
    PRS 95.1
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.94
    rCSI 4.96%
    PRS 88.96
  • respiratory goblet cell CL0002370
    CSI 0.72
    rCSI 7.85%
    PRS 90.73
  • pre-conventional dendritic cell CL0002010
    CSI 0.72
    rCSI 9.54%
    PRS 96.16
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.69
    rCSI 2.01%
    PRS 84.94
  • myelocyte CL0002193
    CSI 0.5
    rCSI 3.28%
    PRS 94.5
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.41
    rCSI 6.1%
    PRS 91.57

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [RAB32](/details-gene/10981) is a protein-coding gene located on chromosome 6q24.3 that encodes a member of the Ras superfamily of small GTPases. As a key regulator of intracellular trafficking, [RAB32](/details-gene/10981) is involved in vesicle-mediated transport, particularly related to melanosome biogenesis, phagosome maturation, and mitochondrial dynamics. Expression data reveals its significant role primarily within the myeloid lineage, showing high specificity in progenitor populations such as [granulocyte monocyte progenitor cell](/details-cell/CL0000557) and [common myeloid progenitor](/details-cell/CL0000049). It is also a key marker for [melanocyte](/details-cell/CL0000148), which is consistent with its established function in pigmentation pathways. ## Cellular Roles and Expression Landscape The expression profile of [RAB32](/details-gene/10981) highlights its central role in hematopoiesis, specifically in the development and function of the myeloid arm of the immune system. **Overall**, the gene shows the highest significance in myeloid precursors, including [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 43.53), [promyelocyte](/details-cell/CL0000836) (CSI: 31.21), and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 30.17). This pattern continues in more differentiated myeloid cells such as [myeloid leukocyte](/details-cell/CL0000766), [promonocyte](/details-cell/CL0000559), and [conventional dendritic cell](/details-cell/CL0000990), suggesting a sustained requirement for [RAB32](/details-gene/10981) function throughout myeloid maturation and in professional antigen-presenting cells. A second, highly distinct cellular context for [RAB32](/details-gene/10981) is in pigment-producing cells, where it is a significant marker for [melanocyte](/details-cell/CL0000148) (CSI: 26.98). This expression is strongly supported by its functional involvement in the formation and transport of melanosomes. The gene also shows notable expression in specialized phagocytic cells like the placental [Hofbauer cell](/details-cell/CL3000001) and the skin-resident [Langerhans cell](/details-cell/CL0000453), further underscoring its role in innate immunity. Modest significance in epithelial cells such as [pancreatic ductal cell](/details-cell/CL0002079) and [colonocyte](/details-cell/CL1000347) may indicate broader, but less prominent, roles in organ-specific transport processes. ## Pathways and Molecular Function [RAB32](/details-gene/10981) functions as a canonical small GTPase, cycling between an active GTP-bound and an inactive GDP-bound state to regulate intracellular membrane trafficking. Its involvement is annotated in several key transport pathways, including '[Vesicle-mediated transport](/details-cell/R-HSA-5653656)' and '[Rab regulation of trafficking](/details-cell/R-HSA-9007101)'. The gene's specific biological roles align closely with its cellular expression pattern. Its high expression in [myeloid leukocyte](/details-cell/CL0000766) and dendritic cells is consistent with its function in '[Phagosome maturation](/details-cell/GO:0090382)' and '[Antigen processing and presentation](/details-cell/GO:0019882)'. Research suggests that [RAB32](/details-gene/10981) is recruited to phagosomes and plays a role in controlling infections by intracellular pathogens like mycobacteria ([Link](https://doi.org/10.1111/j.1600-0854.2011.01165.x)). In [melanocyte](/details-cell/CL0000148), [RAB32](/details-gene/10981) is a critical component of pigmentation machinery. It is functionally linked to '[Endosome to melanosome transport](/details-cell/GO:0035646)' and '[Melanosome organization](/details-cell/GO:0032438)'. This role is mediated in part by its interaction with the BLOC-3 complex, which acts as a guanine nucleotide exchange factor for [RAB32](/details-gene/10981) and is mutated in Hermansky-Pudlak syndrome, a genetic disorder characterized by oculocutaneous albinism ([Link](https://doi.org/10.1016/j.cub.2012.09.020)). Furthermore, [RAB32](/details-gene/10981) has been identified as an A-kinase anchoring protein (AKAP) that localizes to the mitochondrial outer membrane and participates in '[Mitochondrion organization](/details-cell/GO:0007005)' and dynamics, thereby linking cellular signaling pathways to mitochondrial function ([Link](https://doi.org/10.1083/jcb.200204081)). ## Research Directions Given the dual roles of [RAB32](/details-gene/10981) in immunity and organelle biology, several research avenues are compelling. A key area is understanding how its function in myeloid cells is modulated during infection and inflammation, as its role in phagosome maturation makes it a potential host factor in controlling intracellular pathogens. Based on the available data, the following hypotheses can be proposed: 1. [RAB32](/details-gene/10981) is a critical regulator of antimicrobial effector functions in macrophages. Its depletion would not only impair phagosome maturation but also disrupt the mitochondria-endoplasmic reticulum contacts necessary for mounting an effective innate immune response to pathogens. 2. In melanoma, the misregulation of [RAB32](/details-gene/10981) contributes to disease progression by altering melanosome trafficking, which could affect antigen presentation, and by modulating mitochondrial dynamics, which could provide a metabolic advantage to cancer cells. **Experimental Approach to Test Hypothesis 1:** To test the role of [RAB32](/details-gene/10981) in macrophage antimicrobial function, a CRISPR-Cas9 knockout could be generated in a human monocyte cell line (e.g., THP-1). These cells would be differentiated into macrophages and subsequently infected with an intracellular bacterium like *Salmonella enterica* serovar Typhimurium or *Mycobacterium tuberculosis*. The impact of [RAB32](/details-gene/10981) deletion would be assessed by quantifying bacterial survival using colony-forming unit (CFU) assays. Furthermore, confocal microscopy could be used to analyze phagosome maturation (by tracking recruitment of markers like LAMP1) and to visualize mitochondria-ER contact sites (by co-staining for mitochondrial and ER markers) in infected knockout versus wild-type cells. **Therapeutic Potential:** As an intracellular GTPase, [RAB32](/details-gene/10981) presents a challenging therapeutic target for direct inhibition. However, modulating its activity could have therapeutic benefits. For instance, strategies to enhance [RAB32](/details-gene/10981) function or its downstream pathways could be explored as a host-directed therapy to improve bacterial clearance in infectious diseases. Conversely, in the context of melanoma where altered trafficking and metabolism are hallmarks, inhibition of [RAB32](/details-gene/10981) or its specific effectors might be a viable strategy. Targeting its regulatory proteins, such as its specific GEFs or GAPs, may offer a more tractable approach than directly targeting the GTP-binding pocket.

Genular Protein ID: 3198287051

Symbol: RAB32_HUMAN

Name: Ras-related protein Rab-32

UniProtKB Accession Codes:

Q13637

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11784320

Title: Molecular cloning, bacterial expression and properties of Rab31 and Rab32.

PubMed ID: 11784320

DOI: 10.1046/j.0014-2956.2001.02645.x

PubMed ID: 12186851

Title: Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics.

PubMed ID: 12186851

DOI: 10.1083/jcb.200204081

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21808068

Title: RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

PubMed ID: 21808068

DOI: 10.1074/jbc.m111.261115

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 23084991

Title: BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.

PubMed ID: 23084991

DOI: 10.1016/j.cub.2012.09.020

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24856514

Title: VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

PubMed ID: 24856514

DOI: 10.1016/j.devcel.2014.04.010

Sequence Information:

  • Length: 225
  • Mass: 24997
  • Checksum: 91D41BAC1E3434CA
  • Sequence:
    • MAGGGAGDPG LGAAAAPAPE TREHLFKVLV IGELGVGKTS IIKRYVHQLF SQHYRATIGV 
DFALKVLNWD SRTLVRLQLW DIAGQERFGN MTRVYYKEAV GAFVVFDISR SSTFEAVLKW 
KSDLDSKVHL PNGSPIPAVL LANKCDQNKD SSQSPSQVDQ FCKEHGFAGW FETSAKDNIN 
IEEAARFLVE KILVNHQSFP NEENDVDKIK LDQETLRAEN KSQCC