Details for: RAB32

Gene ID: 10981

Symbol: RAB32

Ensembl ID: ENSG00000118508

Description: RAB32, member RAS oncogene family

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.55
    Marker Score: 3,639
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.46
    Marker Score: 618
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.95
    Marker Score: 1,076
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9
    Marker Score: 106,284
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.84
    Marker Score: 1,842
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.83
    Marker Score: 747
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.63
    Marker Score: 4,071
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.63
    Marker Score: 704
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.59
    Marker Score: 6,864
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.59
    Marker Score: 754
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.58
    Marker Score: 563
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.5
    Marker Score: 1,717
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.47
    Marker Score: 925
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,058
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.46
    Marker Score: 1,754
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.39
    Marker Score: 47,327
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.38
    Marker Score: 6,789
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.35
    Marker Score: 3,496
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.31
    Marker Score: 4,854
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.3
    Marker Score: 634
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.27
    Marker Score: 3,977
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.25
    Marker Score: 1,273
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.18
    Marker Score: 4,533
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.17
    Marker Score: 377
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.16
    Marker Score: 1,234
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.14
    Marker Score: 788
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.13
    Marker Score: 28,840
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.12
    Marker Score: 1,646
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.11
    Marker Score: 549
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.07
    Marker Score: 515
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.07
    Marker Score: 403
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.06
    Marker Score: 442
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.03
    Marker Score: 1,074
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.02
    Marker Score: 458
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.02
    Marker Score: 6,199
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 606
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1
    Marker Score: 11,254
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 978
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.98
    Marker Score: 2,565
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.96
    Marker Score: 221
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.96
    Marker Score: 545
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.95
    Marker Score: 1,846
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.95
    Marker Score: 1,301
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.94
    Marker Score: 263
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 262
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,242
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.92
    Marker Score: 2,499
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.92
    Marker Score: 206
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.91
    Marker Score: 969
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.9
    Marker Score: 850
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9
    Marker Score: 2,205
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1,821
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.87
    Marker Score: 3,624
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,254
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.86
    Marker Score: 623
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.85
    Marker Score: 292
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.82
    Marker Score: 233
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1,713
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.82
    Marker Score: 2,907
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.81
    Marker Score: 402
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.8
    Marker Score: 505
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 862
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.8
    Marker Score: 986
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.79
    Marker Score: 1,301
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1,346
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.79
    Marker Score: 1,398
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.77
    Marker Score: 470
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.76
    Marker Score: 601
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 442
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.76
    Marker Score: 4,863
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1,318
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.75
    Marker Score: 3,589
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.74
    Marker Score: 865
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 236
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.73
    Marker Score: 392
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.73
    Marker Score: 769
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.72
    Marker Score: 327
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.72
    Marker Score: 479
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.72
    Marker Score: 261
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1,131
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,955
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7
    Marker Score: 1,597
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7
    Marker Score: 1,399
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.7
    Marker Score: 1,647
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.7
    Marker Score: 347

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB32 is a small GTPase that belongs to the RAS oncogene family, which includes other well-known oncogenes such as RAS, RHO, and RAB. These proteins are characterized by their small size, GTP-binding domains, and ability to regulate downstream effector proteins through GTPase activity. RAB32 is specifically localized to the endoplasmic reticulum (ER) and early endosomes, where it regulates the trafficking of proteins and lipids within the endomembrane system. RAB32 is also involved in the regulation of melanosome assembly and transport, which is essential for the development and function of melanocytes. The gene is highly expressed in cells of the immune system, particularly in classical monocytes and macrophages, where it plays a critical role in the regulation of antigen processing and presentation. **Pathways and Functions** RAB32 is involved in several cellular pathways, including: 1. **Antigen processing and presentation**: RAB32 regulates the trafficking of proteins and lipids within the endomembrane system, which is essential for the processing and presentation of antigens to T-cells. 2. **Endosome-to-melanosome transport**: RAB32 regulates the transport of melanosome components from the endosome to the melanosome, which is essential for the development and function of melanocytes. 3. **Protein trafficking**: RAB32 regulates the trafficking of proteins within the endomembrane system, which is essential for various cellular processes, including protein secretion and cell signaling. 4. **GTP-dependent protein binding**: RAB32 regulates the binding of GTP-dependent proteins to its effector proteins, which is essential for the regulation of downstream signaling pathways. **Clinical Significance** Dysregulation of RAB32 has been implicated in several diseases, including: 1. **Cancer**: RAB32 is overexpressed in several types of cancer, including melanoma, where it is involved in the regulation of tumor cell migration and invasion. 2. **Autoimmune disorders**: RAB32 is involved in the regulation of antigen processing and presentation, which is essential for the development of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative disorders**: RAB32 is involved in the regulation of protein trafficking and endosomal function, which is essential for the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RAB32 is a critical regulator of cellular processes, including endomembrane system organization, protein trafficking, and melanosome assembly and transport. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3198287051

Symbol: RAB32_HUMAN

Name: Ras-related protein Rab-32

UniProtKB Accession Codes:

Q13637

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11784320

Title: Molecular cloning, bacterial expression and properties of Rab31 and Rab32.

PubMed ID: 11784320

DOI: 10.1046/j.0014-2956.2001.02645.x

PubMed ID: 12186851

Title: Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics.

PubMed ID: 12186851

DOI: 10.1083/jcb.200204081

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21808068

Title: RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

PubMed ID: 21808068

DOI: 10.1074/jbc.m111.261115

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 23084991

Title: BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.

PubMed ID: 23084991

DOI: 10.1016/j.cub.2012.09.020

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24856514

Title: VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

PubMed ID: 24856514

DOI: 10.1016/j.devcel.2014.04.010

Sequence Information:

  • Length: 225
  • Mass: 24997
  • Checksum: 91D41BAC1E3434CA
  • Sequence:
    • MAGGGAGDPG LGAAAAPAPE TREHLFKVLV IGELGVGKTS IIKRYVHQLF SQHYRATIGV 
DFALKVLNWD SRTLVRLQLW DIAGQERFGN MTRVYYKEAV GAFVVFDISR SSTFEAVLKW 
KSDLDSKVHL PNGSPIPAVL LANKCDQNKD SSQSPSQVDQ FCKEHGFAGW FETSAKDNIN 
IEEAARFLVE KILVNHQSFP NEENDVDKIK LDQETLRAEN KSQCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.