Details for: COPS5
Associated with
Other Information
Genular Protein ID: 19542204
Symbol: CSN5_HUMAN
Name: COP9 signalosome complex subunit 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8837781
Title: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
PubMed ID: 8837781
DOI: 10.1038/383453a0
PubMed ID: 9341143
Title: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.
PubMed ID: 9341143
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 9535219
Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.
PubMed ID: 9535219
PubMed ID: 10362352
Title: The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
PubMed ID: 10362352
PubMed ID: 10722692
Title: JAB1 interacts with both the progesterone receptor and SRC-1.
PubMed ID: 10722692
PubMed ID: 11089976
Title: Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.
PubMed ID: 11089976
DOI: 10.1038/35041591
PubMed ID: 10766246
Title: Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.
PubMed ID: 10766246
DOI: 10.1038/35007098
PubMed ID: 11285227
Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
PubMed ID: 11285227
PubMed ID: 11337588
Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.
PubMed ID: 11337588
PubMed ID: 11818334
Title: Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation.
PubMed ID: 11818334
PubMed ID: 11709497
Title: Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway.
PubMed ID: 11709497
PubMed ID: 12082530
Title: Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
PubMed ID: 12082530
PubMed ID: 12732143
Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
PubMed ID: 12732143
PubMed ID: 12628923
Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
PubMed ID: 12628923
DOI: 10.1093/emboj/cdg127
PubMed ID: 14500717
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
PubMed ID: 14500717
PubMed ID: 15126503
Title: Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.
PubMed ID: 15126503
PubMed ID: 14993265
Title: Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation.
PubMed ID: 14993265
PubMed ID: 16300740
Title: Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.
PubMed ID: 16300740
PubMed ID: 17123647
Title: Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1.
PubMed ID: 17123647
PubMed ID: 17050680
Title: RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins.
PubMed ID: 17050680
PubMed ID: 18850735
Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
PubMed ID: 18850735
DOI: 10.1021/pr800574c
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19214193
Title: K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.
PubMed ID: 19214193
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 20978819
Title: Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.
PubMed ID: 20978819
PubMed ID: 21102408
Title: CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
PubMed ID: 21102408
PubMed ID: 21499297
Title: C10ORF97 is a novel tumor-suppressor gene of non-small-cell lung cancer and a functional variant of this gene increases the risk of non-small-cell lung cancer.
PubMed ID: 21499297
DOI: 10.1038/onc.2011.116
PubMed ID: 22609399
Title: Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.
PubMed ID: 22609399
PubMed ID: 23776465
Title: Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
PubMed ID: 23776465
PubMed ID: 26456823
Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.
PubMed ID: 26456823
Sequence Information:
- Length: 334
- Mass: 37579
- Checksum: B5742F4AAD03A1CF
- Sequence:
MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.