Details for: METAP2

Gene ID: 10988

Symbol: METAP2

Ensembl ID: ENSG00000111142

Description: methionyl aminopeptidase 2

Associated with

Other Information

Genular Protein ID: 3880865115

Symbol: MAP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7644482

Title: Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.

PubMed ID: 7644482

DOI: 10.1073/pnas.92.17.7714

PubMed ID: 7873610

Title: Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67).

PubMed ID: 7873610

DOI: 10.1016/0167-4781(94)00227-t

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2511207

Title: Glycosylation of eukaryotic peptide chain initiation factor 2 (eIF-2)-associated 67-kDa polypeptide (p67) and its possible role in the inhibition of eIF-2 kinase-catalyzed phosphorylation of the eIF-2 alpha-subunit.

PubMed ID: 2511207

DOI: 10.1016/s0021-9258(19)47108-1

PubMed ID: 12718546

Title: Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese.

PubMed ID: 12718546

DOI: 10.1021/bi020670c

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20521764

Title: Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.

PubMed ID: 20521764

DOI: 10.1021/bi1005464

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21537465

Title: Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein.

PubMed ID: 21537465

DOI: 10.4331/wjbc.v1.i10.313

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9812898

Title: Structure of human methionine aminopeptidase-2 complexed with fumagillin.

PubMed ID: 9812898

DOI: 10.1126/science.282.5392.1324

PubMed ID: 14534293

Title: Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.

PubMed ID: 14534293

DOI: 10.1074/jbc.m309039200

PubMed ID: 15012983

Title: 3-amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.

PubMed ID: 15012983

DOI: 10.1016/j.bmcl.2003.12.031

PubMed ID: 16134930

Title: 4-aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

PubMed ID: 16134930

DOI: 10.1021/jm050408c

PubMed ID: 16540317

Title: Human methionine aminopeptidase type 2 in complex with L- and D-methionine.

PubMed ID: 16540317

DOI: 10.1016/j.bmcl.2006.02.047

PubMed ID: 17350258

Title: Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids.

PubMed ID: 17350258

DOI: 10.1016/j.bmcl.2007.02.062

PubMed ID: 17636946

Title: Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

PubMed ID: 17636946

DOI: 10.1021/jm061182w

Sequence Information:

  • Length: 478
  • Mass: 52892
  • Checksum: 5788E4BB83E48F9A
  • Sequence:
  • MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES 
    GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI 
    CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR 
    KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT 
    VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDTLLKAV KDATNTGIKC AGIDVRLCDV 
    GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGQYRIHA GKTVPIVKGG EATRMEEGEV 
    YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL 
    DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY

Genular Protein ID: 2735267263

Symbol: F8VQZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 477
  • Mass: 52820
  • Checksum: 2ABB853D47E76249
  • Sequence:
  • MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA GEQEPDKESG 
    ASVDEVARQL ERSALEDKER DEDDEDGDGD GDGATGKKKK KKKKKRGPKV QTDPPSVPIC 
    DLYPNGVFPK GQECEYPPTQ DGRTAAWRTT SEEKKALDQA SEEIWNDFRE AAEAHRQVRK 
    YVMSWIKPGM TMIEICEKLE DCSRKLIKEN GLNAGLAFPT GCSLNNCAAH YTPNAGDTTV 
    LQYDDICKID FGTHISGRII DCAFTVTFNP KYDTLLKAVK DATNTGIKCA GIDVRLCDVG 
    EAIQEVMESY EVEIDGKTYQ VKPIRNLNGH SIGQYRIHAG KTVPIVKGGE ATRMEEGEVY 
    AIETFGSTGK GVVHDDMECS HYMKNFDVGH VPIRLPRTKH LLNVINENFG TLAFCRRWLD 
    RLGESKYLMA LKNLCDLGIV DPYPPLCDIK GSYTAQFEHT ILLRPTCKEV VSRGDDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.