Details for: SLC27A5

Gene ID: 10998

Symbol: SLC27A5

Ensembl ID: ENSG00000083807

Description: solute carrier family 27 member 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.72
    Marker Score: 9,258
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.55
    Marker Score: 9,986
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.55
    Marker Score: 6,698
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.5
    Marker Score: 1,018
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.16
    Marker Score: 1,131
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.03
    Marker Score: 1,072
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,753
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 629
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.91
    Marker Score: 7,966
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,179
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2,132
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,967
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1,569
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.79
    Marker Score: 1,380
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.73
    Marker Score: 44,998
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.73
    Marker Score: 780
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.71
    Marker Score: 531
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7
    Marker Score: 1,432
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.7
    Marker Score: 645
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.69
    Marker Score: 1,069
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.69
    Marker Score: 6,491
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.68
    Marker Score: 6,494
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.68
    Marker Score: 339
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5,816
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,835
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.67
    Marker Score: 4,314
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 214
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.63
    Marker Score: 1,589
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.63
    Marker Score: 235
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.63
    Marker Score: 1,327
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 22,893
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.62
    Marker Score: 6,403
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 912
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.62
    Marker Score: 23,433
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.61
    Marker Score: 1,400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.61
    Marker Score: 1,017
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.61
    Marker Score: 2,271
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.61
    Marker Score: 647
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.6
    Marker Score: 1,067
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2,290
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.59
    Marker Score: 950
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.59
    Marker Score: 309
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.58
    Marker Score: 11,587
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1,183
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.58
    Marker Score: 4,422
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 381
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 615
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.56
    Marker Score: 8,417
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.56
    Marker Score: 2,275
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.55
    Marker Score: 1,465
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.55
    Marker Score: 237
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.54
    Marker Score: 162
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 321
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 378
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.51
    Marker Score: 254
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.51
    Marker Score: 1,822
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.51
    Marker Score: 833
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5
    Marker Score: 336
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.5
    Marker Score: 2,035
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 500
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.49
    Marker Score: 1,024
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 313
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.49
    Marker Score: 141
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.48
    Marker Score: 346
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.47
    Marker Score: 111
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.47
    Marker Score: 16,386
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.47
    Marker Score: 1,113
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.47
    Marker Score: 190
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.46
    Marker Score: 131
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 210
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.45
    Marker Score: 1,022
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.45
    Marker Score: 359
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.44
    Marker Score: 1,822
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.44
    Marker Score: 86
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.44
    Marker Score: 136

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SLC27A5 is widely expressed in various tissues, including periportal region hepatocyte, centrilobular region hepatocyte, midzonal region hepatocyte, proerythroblast, pancreatic A cell, erythroid progenitor cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, and intestinal crypt stem cell of colon. 2. **Protein Structure:** The protein encoded by SLC27A5 is a member of the solute carrier family 27 and consists of 12 transmembrane domains with a large N-terminal domain. 3. **Function:** SLC27A5 is involved in the transport of long-chain fatty acids and bile acids across cell membranes, playing a crucial role in fatty acid and bile acid metabolism. **Pathways and Functions:** 1. **Fatty Acid Metabolism:** SLC27A5 is involved in the biosynthesis of very long-chain fatty acids, which are essential for energy production, cell membrane synthesis, and signaling pathways. 2. **Bile Acid Metabolism:** SLC27A5 is also involved in the transport of bile acids across cell membranes, playing a crucial role in the regulation of bile acid homeostasis. 3. **Long-Chain Fatty Acid-CoA Ligase Activity:** SLC27A5 encodes a fatty-acid-coenzyme A ligase enzyme that catalyzes the formation of covalent bonds between long-chain fatty acids and coenzyme A, a key step in fatty acid metabolism. 4. **Bile Acid Biosynthesis and Metabolic Process:** SLC27A5 is involved in the synthesis of bile acids from cholesterol, which is essential for the regulation of lipid metabolism and energy production. **Clinical Significance:** 1. **Fatty Liver Disease:** Alterations in SLC27A5 expression have been linked to fatty liver disease, a condition characterized by excessive fat accumulation in the liver. 2. **Bile Acid Dysregulation:** Dysregulation of SLC27A5 has been implicated in bile acid dysregulation, which can lead to liver disease, obesity, and metabolic disorders. 3. **Cancer:** Overexpression of SLC27A5 has been observed in certain types of cancer, including pancreatic cancer, suggesting a potential role in cancer development and progression. 4. **Neurological Disorders:** SLC27A5 has been implicated in neurological disorders, including epilepsy and schizophrenia, suggesting a potential role in neural function and development. In conclusion, SLC27A5 plays a crucial role in fatty acid and bile acid metabolism, and its dysregulation has been implicated in various diseases, including fatty liver disease, bile acid dysregulation, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms underlying SLC27A5 function and its clinical significance.

Genular Protein ID: 1973316476

Symbol: S27A5_HUMAN

Name: Fatty-acid-coenzyme A ligase, very long-chain 3

UniProtKB Accession Codes:

Q9Y2P5 B3KVP6 B4DPQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 68 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 23 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10479480

Title: Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein.

PubMed ID: 10479480

DOI: 10.1006/mgme.1999.2883

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 10749848

Title: The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase.

PubMed ID: 10749848

DOI: 10.1074/jbc.c000015200

PubMed ID: 11980911

Title: Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.

PubMed ID: 11980911

DOI: 10.1074/jbc.m203295200

PubMed ID: 20448275

Title: Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

PubMed ID: 20448275

DOI: 10.1177/1087057110369700

PubMed ID: 20530735

Title: FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.

PubMed ID: 20530735

DOI: 10.1152/ajpendo.00226.2010

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 690
  • Mass: 75385
  • Checksum: 011313424D794546
  • Sequence:
    • MGVRQQLALL LLLLLLLWGL GQPVWPVAVA LTLRWLLGDP TCCVLLGLAM LARPWLGPWV 
PHGLSLAAAA LALTLLPARL PPGLRWLPAD VIFLAKILHL GLKIRGCLSR QPPDTFVDAF 
ERRARAQPGR ALLVWTGPGA GSVTFGELDA RACQAAWALK AELGDPASLC AGEPTALLVL 
ASQAVPALCM WLGLAKLGCP TAWINPHGRG MPLAHSVLSS GARVLVVDPD LRESLEEILP 
KLQAENIRCF YLSHTSPTPG VGALGAALDA APSHPVPADL RAGITWRSPA LFIYTSGTTG 
LPKPAILTHE RVLQMSKMLS LSGATADDVV YTVLPLYHVM GLVVGILGCL DLGATCVLAP 
KFSTSCFWDD CRQHGVTVIL YVGELLRYLC NIPQQPEDRT HTVRLAMGNG LRADVWETFQ 
QRFGPIRIWE VYGSTEGNMG LVNYVGRCGA LGKMSCLLRM LSPFELVQFD MEAAEPVRDN 
QGFCIPVGLG EPGLLLTKVV SQQPFVGYRG PRELSERKLV RNVRQSGDVY YNTGDVLAMD 
REGFLYFRDR LGDTFRWKGE NVSTHEVEGV LSQVDFLQQV NVYGVCVPGC EGKVGMAAVQ 
LAPGQTFDGE KLYQHVRAWL PAYATPHFIR IQDAMEVTST FKLMKTRLVR EGFNVGIVVD 
PLFVLDNRAQ SFRPLTAEMY QAVCEGTWRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.