SLC27A4 | ENSG00000167114 | NCBI 10999

Details for: SLC27A4

Gene ID: 10999

Symbol: SLC27A4

Ensembl ID: ENSG00000167114

Description: solute carrier family 27 member 4

Associated with

Defective slc27a4 causes ichthyosis prematurity syndrome (ips)
(R-HSA-5619108)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Slc-mediated transmembrane transport
(R-HSA-425407)
Slc transporter disorders
(R-HSA-5619102)
Transport of fatty acids
(R-HSA-804914)
Transport of small molecules
(R-HSA-382551)
Transport of vitamins, nucleosides, and related molecules
(R-HSA-425397)
Activation of gtpase activity
(GO:0090630)
Arachidonate-coa ligase activity
(GO:0047676)
Brush border membrane
(GO:0031526)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Establishment of localization in cell
(GO:0051649)
Fatty acid metabolic process
(GO:0006631)
Fatty acid transmembrane transporter activity
(GO:0015245)
Fatty acid transport
(GO:0015908)
Glucose import in response to insulin stimulus
(GO:0044381)
Lipid transport across blood-brain barrier
(GO:1990379)
Long-chain fatty acid-coa ligase activity
(GO:0004467)
Long-chain fatty acid import into cell
(GO:0044539)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid transport
(GO:0015909)
Long-chain fatty acid transporter activity
(GO:0005324)
Medium-chain fatty acid transport
(GO:0001579)
Membrane
(GO:0016020)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Nucleotide binding
(GO:0000166)
Oleate transmembrane transporter activity
(GO:1901480)
Oleoyl-coa ligase activity
(GO:0090434)
Palmitoyl-coa ligase activity
(GO:0090433)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Skin development
(GO:0043588)
Transport across blood-brain barrier
(GO:0150104)
Very long-chain fatty acid-coa ligase activity
(GO:0031957)

Other Information

Proteins

Solute carrier family 27 member 4

Genular Protein ID: 2583779138

Symbol: S27A4_HUMAN

Name: Solute carrier family 27 member 4

UniProtKB Accession Codes:

Q6P1M0 A8K2F7 O95186 Q96G53

Database IDs:

Citations:

PubMed ID: 9878842

Title: Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4).

PubMed ID: 9878842

DOI: 10.1016/s0167-4781(98)00231-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10518211

Title: Identification of the major intestinal fatty acid transport protein.

PubMed ID: 10518211

DOI: 10.1016/s1097-2765(00)80332-9

PubMed ID: 12556534

Title: Characterization of a heart-specific fatty acid transport protein.

PubMed ID: 12556534

DOI: 10.1074/jbc.m211412200

PubMed ID: 20448275

Title: Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

PubMed ID: 20448275

DOI: 10.1177/1087057110369700

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22022213

Title: Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.

PubMed ID: 22022213

DOI: 10.7150/ijms.8.599

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

PubMed ID: 14715877

Title: Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome.

PubMed ID: 14715877

DOI: 10.1210/jc.2003-030682

PubMed ID: 19631310

Title: Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.

PubMed ID: 19631310

DOI: 10.1016/j.ajhg.2009.06.021

PubMed ID: 20815031

Title: A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis.

PubMed ID: 20815031

DOI: 10.1002/ajmg.a.33648

Sequence Information:

Length: 643
Mass: 72064
Checksum: 95E677DB3CEB9A14
Sequence:

MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR RDIFGGLVLL 
KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 
RGLASGDVAA IFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALLHCLT TSRARALVFG 
SEMASAICEV HASLDPSLSL FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK 
LFYIYTSGTT GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ 
CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE NQHQVRMALG 
NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV GACGFNSRIL SFVYPIRLVR 
VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR IIQKDPLRRF DGYLNQGANN KKIAKDVFKK 
GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE 
VPGTEGRAGM AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE 
LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC27A4

Associated with

Other Information

Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). PubMed ID: 9878842

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the major intestinal fatty acid transport protein. PubMed ID: 10518211

Characterization of a heart-specific fatty acid transport protein. PubMed ID: 12556534

Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. PubMed ID: 20448275

Initial characterization of the human central proteome. PubMed ID: 21269460

Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. PubMed ID: 21395585

Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. PubMed ID: 22022213

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. PubMed ID: 24269233

Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. PubMed ID: 14715877

Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. PubMed ID: 19631310

A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis. PubMed ID: 20815031