Details for: SLC27A4

Gene ID: 10999

Symbol: SLC27A4

Ensembl ID: ENSG00000167114

Description: solute carrier family 27 member 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,709
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.44
    Marker Score: 14,875
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2,089
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.33
    Marker Score: 48,927
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.29
    Marker Score: 5,237
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.23
    Marker Score: 75,619
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.2
    Marker Score: 432
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.15
    Marker Score: 9,840
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.12
    Marker Score: 10,541
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10,509
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4,579
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.06
    Marker Score: 5,074
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.02
    Marker Score: 38,575
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1
    Marker Score: 3,859
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.91
    Marker Score: 383
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.9
    Marker Score: 17,859
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.9
    Marker Score: 7,734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.88
    Marker Score: 6,724
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,272
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.87
    Marker Score: 12,953
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.83
    Marker Score: 1,205
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12,903
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.8
    Marker Score: 1,240
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.77
    Marker Score: 3,565
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.76
    Marker Score: 209
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 702
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.71
    Marker Score: 5,526
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,933
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.67
    Marker Score: 1,132
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1,345
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.64
    Marker Score: 535
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.63
    Marker Score: 154
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.63
    Marker Score: 21,111
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.62
    Marker Score: 161
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.62
    Marker Score: 408
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.61
    Marker Score: 9,848
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.61
    Marker Score: 155
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.58
    Marker Score: 12,440
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.58
    Marker Score: 857
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,350
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.56
    Marker Score: 922
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1,361
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.55
    Marker Score: 1,738
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.54
    Marker Score: 283
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.54
    Marker Score: 1,283
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.53
    Marker Score: 371
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.53
    Marker Score: 1,428
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.53
    Marker Score: 582
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.51
    Marker Score: 543
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.51
    Marker Score: 506
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.5
    Marker Score: 332
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 332
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.5
    Marker Score: 1,294
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.5
    Marker Score: 100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.49
    Marker Score: 185
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2,926
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.46
    Marker Score: 395
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 458
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.45
    Marker Score: 243
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.44
    Marker Score: 624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.44
    Marker Score: 839
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.43
    Marker Score: 500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.43
    Marker Score: 1,095
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 910
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.43
    Marker Score: 942
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.43
    Marker Score: 459
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.42
    Marker Score: 1,211
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.42
    Marker Score: 472
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.41
    Marker Score: 319
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.41
    Marker Score: 2,639
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.41
    Marker Score: 119
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 247
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 511
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.41
    Marker Score: 146
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 237
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.38
    Marker Score: 367
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.38
    Marker Score: 287
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 537
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.37
    Marker Score: 1,604

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC27A4 gene is a member of the solute carrier family 27, which consists of several transmembrane proteins involved in the transport of various molecules across cell membranes. The SLC27A4 protein is specifically characterized by its ability to transport long-chain fatty acids, which are essential for energy production, cell growth, and development. The protein is also involved in the regulation of insulin signaling pathways and the establishment of localization in cells. **Pathways and Functions** The SLC27A4 protein is involved in several cellular pathways, including: 1. **Fatty acid metabolism**: The SLC27A4 protein is responsible for the transport of long-chain fatty acids across cell membranes, which is essential for energy production, cell growth, and development. 2. **Insulin signaling**: The SLC27A4 protein is involved in the regulation of insulin signaling pathways, which are critical for glucose uptake and energy metabolism. 3. **Cell localization**: The SLC27A4 protein is involved in the establishment of localization in cells, which is essential for proper cell function and development. 4. **Blood-brain barrier transport**: The SLC27A4 protein is also involved in the transport of fatty acids across the blood-brain barrier, which is essential for proper brain function and development. **Clinical Significance** Mutations in the SLC27A4 gene have been associated with Ichthyosis Prematurity Syndrome (IPS), a rare disorder characterized by premature birth and skin abnormalities. IPS is caused by mutations in the SLC27A4 gene, which disrupt the normal function of the SLC27A4 protein and lead to impaired fatty acid metabolism, insulin signaling, and cell localization. In addition to IPS, mutations in the SLC27A4 gene have also been associated with other disorders, including: 1. **Disorders of transmembrane transporters**: Mutations in the SLC27A4 gene can lead to disorders of transmembrane transporters, which can result in impaired transport of essential molecules across cell membranes. 2. **Skin development**: Mutations in the SLC27A4 gene can also lead to impaired skin development, which can result in skin abnormalities and premature aging. 3. **Neurological disorders**: Mutations in the SLC27A4 gene have also been associated with neurological disorders, including Parkinson's disease and other neurodegenerative disorders. In conclusion, the SLC27A4 gene plays a critical role in various cellular processes, including fatty acid metabolism, insulin signaling, and cell localization. Mutations in the SLC27A4 gene have been associated with Ichthyosis Prematurity Syndrome and other disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 2583779138

Symbol: S27A4_HUMAN

Name: Solute carrier family 27 member 4

UniProtKB Accession Codes:

Q6P1M0 A8K2F7 O95186 Q96G53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 47 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 18 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878842

Title: Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4).

PubMed ID: 9878842

DOI: 10.1016/s0167-4781(98)00231-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10518211

Title: Identification of the major intestinal fatty acid transport protein.

PubMed ID: 10518211

DOI: 10.1016/s1097-2765(00)80332-9

PubMed ID: 12556534

Title: Characterization of a heart-specific fatty acid transport protein.

PubMed ID: 12556534

DOI: 10.1074/jbc.m211412200

PubMed ID: 20448275

Title: Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

PubMed ID: 20448275

DOI: 10.1177/1087057110369700

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22022213

Title: Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.

PubMed ID: 22022213

DOI: 10.7150/ijms.8.599

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

PubMed ID: 14715877

Title: Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome.

PubMed ID: 14715877

DOI: 10.1210/jc.2003-030682

PubMed ID: 19631310

Title: Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.

PubMed ID: 19631310

DOI: 10.1016/j.ajhg.2009.06.021

PubMed ID: 20815031

Title: A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis.

PubMed ID: 20815031

DOI: 10.1002/ajmg.a.33648

Sequence Information:

  • Length: 643
  • Mass: 72064
  • Checksum: 95E677DB3CEB9A14
  • Sequence:
    • MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR RDIFGGLVLL 
KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 
RGLASGDVAA IFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALLHCLT TSRARALVFG 
SEMASAICEV HASLDPSLSL FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK 
LFYIYTSGTT GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ 
CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE NQHQVRMALG 
NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV GACGFNSRIL SFVYPIRLVR 
VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR IIQKDPLRRF DGYLNQGANN KKIAKDVFKK 
GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE 
VPGTEGRAGM AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE 
LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.