Details for: SLC27A3

Gene ID: 11000

Symbol: SLC27A3

Ensembl ID: ENSG00000143554

Description: solute carrier family 27 member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.79
    Marker Score: 10,593
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6
    Marker Score: 1,128
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.46
    Marker Score: 884
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.45
    Marker Score: 2,096
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.33
    Marker Score: 754
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.33
    Marker Score: 1,420
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.17
    Marker Score: 29,997
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.12
    Marker Score: 1,963
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.08
    Marker Score: 262
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.07
    Marker Score: 6,949
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.04
    Marker Score: 295
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,762
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.99
    Marker Score: 10,050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.96
    Marker Score: 432
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.95
    Marker Score: 851
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.94
    Marker Score: 52,627
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.92
    Marker Score: 5,599
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,716
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.89
    Marker Score: 834
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,972
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,258
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,395
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.86
    Marker Score: 3,554
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.85
    Marker Score: 3,670
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.79
    Marker Score: 343
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.76
    Marker Score: 177
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.75
    Marker Score: 937
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.74
    Marker Score: 1,893
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2,807
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.7
    Marker Score: 710
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,878
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.68
    Marker Score: 332
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.68
    Marker Score: 1,326
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6,794
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.67
    Marker Score: 1,070
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.64
    Marker Score: 355
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.64
    Marker Score: 140
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 408
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.62
    Marker Score: 709
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.62
    Marker Score: 181
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.61
    Marker Score: 142
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.6
    Marker Score: 647
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.59
    Marker Score: 178
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.57
    Marker Score: 3,003
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.54
    Marker Score: 133
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.53
    Marker Score: 1,332
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.53
    Marker Score: 201
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.53
    Marker Score: 475
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.52
    Marker Score: 325
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.51
    Marker Score: 609
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5
    Marker Score: 116
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.5
    Marker Score: 1,471
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.5
    Marker Score: 144
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 156
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.49
    Marker Score: 265
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.49
    Marker Score: 128
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.49
    Marker Score: 210
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.48
    Marker Score: 221
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.48
    Marker Score: 771
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.46
    Marker Score: 1,260
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.46
    Marker Score: 327
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.46
    Marker Score: 137
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.46
    Marker Score: 308
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.45
    Marker Score: 434
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.45
    Marker Score: 105
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.45
    Marker Score: 180
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.45
    Marker Score: 114
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.45
    Marker Score: 1,409
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.44
    Marker Score: 154
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.44
    Marker Score: 521
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.44
    Marker Score: 721
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.44
    Marker Score: 739
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.43
    Marker Score: 1,605
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.43
    Marker Score: 122
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.43
    Marker Score: 196
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.43
    Marker Score: 149
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.43
    Marker Score: 235
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.42
    Marker Score: 1,087
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.41
    Marker Score: 395
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.41
    Marker Score: 4,661
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.41
    Marker Score: 439
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 369
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.41
    Marker Score: 134
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.41
    Marker Score: 457

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** SLC27A3 is a long-chain fatty acid-CoA ligase, responsible for the transport of long-chain fatty acids across cellular membranes and their subsequent incorporation into acyl-CoA derivatives. 2. **Cellular localization:** The protein is primarily localized to the plasma membrane and the endoplasmic reticulum, where it participates in fatty acid metabolism. 3. **Expression pattern:** SLC27A3 is significantly expressed in various cell types, including Sertoli cells, monocytes, dendritic cells, endothelial cells, and germ cells. 4. **Pathway involvement:** SLC27A3 is involved in several metabolic pathways, including fatty acid metabolism, long-chain fatty acid transport, and very long-chain fatty acid-CoA biosynthesis. **Pathways and Functions:** 1. **Fatty acid metabolism:** SLC27A3 participates in the metabolism of long-chain fatty acids, converting them into acyl-CoA derivatives that can be used for energy production, lipid synthesis, or storage. 2. **Long-chain fatty acid transport:** The protein facilitates the transport of long-chain fatty acids across cellular membranes, allowing them to be incorporated into acyl-CoA derivatives. 3. **Very long-chain fatty acid-CoA biosynthesis:** SLC27A3 is involved in the biosynthesis of very long-chain fatty acyl-CoAs, which are essential for the production of cholesterol and other biomolecules. 4. **Atp binding:** The protein interacts with ATP, which is necessary for the transport of long-chain fatty acids across cellular membranes. **Clinical Significance:** 1. **Metabolic disorders:** Alterations in SLC27A3 expression or function have been implicated in various metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. 2. **Inflammation:** SLC27A3 has been shown to regulate inflammatory responses, particularly in the context of fatty acid metabolism. 3. **Cardiovascular disease:** The protein's involvement in fatty acid metabolism and inflammation has significant implications for the development of cardiovascular disease. 4. **Cancer:** SLC27A3 has been implicated in the regulation of fatty acid metabolism in cancer cells, which can contribute to cancer progression and metastasis. In conclusion, the SLC27A3 gene plays a crucial role in the regulation of fatty acid metabolism, and its dysregulation has significant implications for human health. Further research is necessary to fully understand the mechanisms by which SLC27A3 influences metabolic processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1450153873

Symbol: S27A3_HUMAN

Name: Long-chain-fatty-acid--CoA ligase

UniProtKB Accession Codes:

Q5K4L6 Q5VUQ7 Q5VUQ8 Q5VUR3 Q6ZV16 Q8N2X7 Q8TEJ0 Q96SW5 Q9BTJ5 Q9BTY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 ChEBI 49 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 15 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23936004

Title: Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.

PubMed ID: 23936004

DOI: 10.1371/journal.pone.0069392

Sequence Information:

  • Length: 683
  • Mass: 73550
  • Checksum: 1B18B85D5FF17A94
  • Sequence:
    • MAALLLLPLL LLLPLLLLKL HLWPQLRWLP ADLAFAVRAL CCKRALRARA LAAAAADPEG 
PEGGCSLAWR LAELAQQRAA HTFLIHGSRR FSYSEAERES NRAARAFLRA LGWDWGPDGG 
DSGEGSAGEG ERAAPGAGDA AAGSGAEFAG GDGAARGGGA AAPLSPGATV ALLLPAGPEF 
LWLWFGLAKA GLRTAFVPTA LRRGPLLHCL RSCGARALVL APEFLESLEP DLPALRAMGL 
HLWAAGPGTH PAGISDLLAE VSAEVDGPVP GYLSSPQSIT DTCLYIFTSG TTGLPKAARI 
SHLKILQCQG FYQLCGVHQE DVIYLALPLY HMSGSLLGIV GCMGIGATVV LKSKFSAGQF 
WEDCQQHRVT VFQYIGELCR YLVNQPPSKA ERGHKVRLAV GSGLRPDTWE RFVRRFGPLQ 
VLETYGLTEG NVATINYTGQ RGAVGRASWL YKHIFPFSLI RYDVTTGEPI RDPQGHCMAT 
SPGEPGLLVA PVSQQSPFLG YAGGPELAQG KLLKDVFRPG DVFFNTGDLL VCDDQGFLRF 
HDRTGDTFRW KGENVATTEV AEVFEALDFL QEVNVYGVTV PGHEGRAGMA ALVLRPPHAL 
DLMQLYTHVS ENLPPYARPR FLRLQESLAT TETFKQQKVR MANEGFDPST LSDPLYVLDQ 
AVGAYLPLTT ARYSALLAGN LRI

Genular Protein ID: 2027466500

Symbol: X6R3N0_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6R3N0

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChEBI 18 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 3 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 4 Proteomes 2 RefSeq 1 Rhea 6 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 811
  • Mass: 87324
  • Checksum: 272764D785C7AC31
  • Sequence:
    • MPKPPKPRNN LEDRHNPGIQ GRREHRPGPG RVRAASSPGG SAPRAERRLW GEGWESGAAP 
HPHSSRVSAL RPCGVVGAWV GMGVCQRTRA PWKEKSQLER AALGFRKGGS GMFASGWNQT 
VPIEEAGSMA ALLLLPLLLL LPLLLLKLHL WPQLRWLPAD LAFAVRALCC KRALRARALA 
AAAADPEGPE GGCSLAWRLA ELAQQRAAHT FLIHGSRRFS YSEAERESNR AARAFLRALG 
WDWGPDGGDS GEGSAGEGER AAPGAGDAAA GSGAEFAGGD GAARGGGAAA PLSPGATVAL 
LLPAGPEFLW LWFGLAKAGL RTAFVPTALR RGPLLHCLRS CGARALVLAP EFLESLEPDL 
PALRAMGLHL WAAGPGTHPA GISDLLAEVS AEVDGPVPGY LSSPQSITDT CLYIFTSGTT 
GLPKAARISH LKILQCQGFY QLCGVHQEDV IYLALPLYHM SGSLLGIVGC MGIGATVVLK 
SKFSAGQFWE DCQQHRVTVF QYIGELCRYL VNQPPSKAER GHKVRLAVGS GLRPDTWERF 
VRRFGPLQVL ETYGLTEGNV ATINYTGQRG AVGRASWLYK HIFPFSLIRY DVTTGEPIRD 
PQGHCMATSP GEPGLLVAPV SQQSPFLGYA GGPELAQGKL LKDVFRPGDV FFNTGDLLVC 
DDQGFLRFHD RTGDTFRWKG ENVATTEVAE VFEALDFLQE VNVYGVTVPG HEGRAGMAAL 
VLRPPHALDL MQLYTHVSEN LPPYARPRFL RLQESLATTE TFKQQKVRMA NEGFDPSTLS 
DPLYVLDQAV GAYLPLTTAR YSALLAGNLR I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.