Details for: SLC27A2

Gene ID: 11001

Symbol: SLC27A2

Ensembl ID: ENSG00000140284

Description: solute carrier family 27 member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 4.5
    Marker Score: 2,952
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.08
    Marker Score: 8,178
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2
    Marker Score: 17,334
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.79
    Marker Score: 6,366
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.72
    Marker Score: 5,927
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.55
    Marker Score: 1,275
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3,356
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8,951
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.37
    Marker Score: 2,600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.34
    Marker Score: 7,187
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.33
    Marker Score: 5,739
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.24
    Marker Score: 341
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.12
    Marker Score: 551
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.1
    Marker Score: 738
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.09
    Marker Score: 3,559
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Marker Score: 6,523
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.03
    Marker Score: 300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Marker Score: 656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.92
    Marker Score: 6,816
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,162
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.85
    Marker Score: 244
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.82
    Marker Score: 264
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.81
    Marker Score: 3,880
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1,286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.78
    Marker Score: 529
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.77
    Marker Score: 365
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.73
    Marker Score: 1,744
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 655
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,985
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.68
    Marker Score: 1,045
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 935
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.62
    Marker Score: 235
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.58
    Marker Score: 270
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.57
    Marker Score: 21,636
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.57
    Marker Score: 260
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.56
    Marker Score: 1,747
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.55
    Marker Score: 157
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.53
    Marker Score: 998
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.52
    Marker Score: 246
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.5
    Marker Score: 287
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.5
    Marker Score: 188
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.49
    Marker Score: 525
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.48
    Marker Score: 4,595
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.46
    Marker Score: 497
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 27,287
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.42
    Marker Score: 1,641
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.42
    Marker Score: 1,215
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.42
    Marker Score: 440
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.42
    Marker Score: 302
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.42
    Marker Score: 758
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.41
    Marker Score: 15,205
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.41
    Marker Score: 3,136
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 187
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4
    Marker Score: 2,578
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 242
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.39
    Marker Score: 95
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 788
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 256
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.38
    Marker Score: 301
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.38
    Marker Score: 134
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.36
    Marker Score: 1,035
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1,463
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 213
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5,537
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.34
    Marker Score: 2,923
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.33
    Marker Score: 121
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.33
    Marker Score: 78
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.33
    Marker Score: 699
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.33
    Marker Score: 343
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.32
    Marker Score: 374
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.31
    Marker Score: 209
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.3
    Marker Score: 112
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.3
    Marker Score: 82
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3
    Marker Score: 156
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 288

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC27A2 is a transmembrane protein with 12 transmembrane domains, which are essential for its function as a fatty acid-CoA ligase. The protein is highly expressed in various tissues, including the immune system, and has been implicated in the regulation of lipid metabolism and immune responses. SLC27A2 is also involved in the synthesis of bile acids and bile salts, which are essential for the maintenance of lipid homeostasis and immune function. **Pathways and Functions:** SLC27A2 is involved in several key pathways, including: 1. **Fatty Acid Metabolism:** SLC27A2 facilitates the incorporation of long-chain fatty acids into acyl-CoA esters, which are then utilized in various cellular processes, including energy production, membrane synthesis, and lipid storage. 2. **Immune System:** SLC27A2 plays a crucial role in the regulation of immune responses, particularly in the context of Th17 cell differentiation and function. Th17 cells are a subset of T cells that are involved in the defense against pathogens and are also implicated in autoimmune diseases. 3. **Bile Acid and Bile Salt Metabolism:** SLC27A2 is involved in the synthesis of bile acids and bile salts, which are essential for the maintenance of lipid homeostasis and immune function. 4. **Peroxisomal Lipid Metabolism:** SLC27A2 is also involved in the regulation of peroxisomal lipid metabolism, which is essential for the breakdown of fatty acids and the production of energy. **Clinical Significance:** Dysregulation of SLC27A2 has been implicated in various diseases, including: 1. **Autoimmune Diseases:** Mutations in SLC27A2 have been associated with an increased risk of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Metabolic Disorders:** SLC27A2 dysfunction has been implicated in metabolic disorders, such as obesity and insulin resistance. 3. **Cancer:** SLC27A2 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer, and has been implicated in the regulation of tumor growth and metastasis. In conclusion, SLC27A2 plays a critical role in the regulation of immune responses and lipid metabolism. Further research is needed to fully understand the mechanisms by which SLC27A2 regulates these processes and to explore the potential therapeutic applications of this gene in the treatment of various diseases.

Genular Protein ID: 1721208352

Symbol: S27A2_HUMAN

Name: Arachidonate--CoA ligase

UniProtKB Accession Codes:

O14975 A8K2J7 Q53FY6 Q6PF09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 29 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 3 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10198260

Title: Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.

PubMed ID: 10198260

DOI: 10.1006/bbrc.1999.0510

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10640429

Title: Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy.

PubMed ID: 10640429

DOI: 10.1006/excr.1999.4757

PubMed ID: 10749848

Title: The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase.

PubMed ID: 10749848

DOI: 10.1074/jbc.c000015200

PubMed ID: 11980911

Title: Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.

PubMed ID: 11980911

DOI: 10.1074/jbc.m203295200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20530735

Title: FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.

PubMed ID: 20530735

DOI: 10.1152/ajpendo.00226.2010

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22022213

Title: Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.

PubMed ID: 22022213

DOI: 10.7150/ijms.8.599

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21768100

Title: Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.

PubMed ID: 21768100

DOI: 10.1074/jbc.m111.226316

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 620
  • Mass: 70312
  • Checksum: 752E2FFBB2E47C26
  • Sequence:
    • MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR PARTILRAFL 
EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 
WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 
YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 
RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 
FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 
EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 
VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 
KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
MYVPMTEDIY NAISAKTLKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.