Details for: SPINK5
Associated with
Other Information
Genular Protein ID: 776900364
Symbol: ISK5_HUMAN
Name: Serine protease inhibitor Kazal-type 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10419450
Title: LEKTI, a novel 15-domain type of human serine proteinase inhibitor.
PubMed ID: 10419450
PubMed ID: 10835624
Title: Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.
PubMed ID: 10835624
DOI: 10.1038/75977
PubMed ID: 16374478
Title: SPINK5, the defective gene in netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing.
PubMed ID: 16374478
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 11511292
Title: The spectrum of pathogenic mutations in SPINK5 in 19 families with Netherton syndrome: implications for mutation detection and first case of prenatal diagnosis.
PubMed ID: 11511292
PubMed ID: 11594460
Title: Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium.
PubMed ID: 11594460
PubMed ID: 17596512
Title: LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction.
PubMed ID: 17596512
PubMed ID: 20533828
Title: New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.
PubMed ID: 20533828
DOI: 10.1021/pr1003467
PubMed ID: 12684009
Title: Homologous proteins with different folds: the three-dimensional structures of domains 1 and 6 of the multiple Kazal-type inhibitor LEKTI.
PubMed ID: 12684009
PubMed ID: 15366933
Title: The solution structure of a chimeric LEKTI domain reveals a chameleon sequence.
PubMed ID: 15366933
DOI: 10.1021/bi0492399
PubMed ID: 11544479
Title: Gene polymorphism in Netherton and common atopic disease.
PubMed ID: 11544479
DOI: 10.1038/ng728
Sequence Information:
- Length: 1064
- Mass: 120714
- Checksum: 6CBEF39BB9E6D75D
- Sequence:
MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF FQSLDGIMFI NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF KKGERDGDFI CPDYYEAVCG TDGKTYDNRC ALCAENAKTG SQIGVKSEGE CKSSNPEQDV CSAFRPFVRD GRLGCTREND PVLGPDGKTH GNKCAMCAEL FLKEAENAKR EGETRIRRNA EKDFCKEYEK QVRNGRLFCT RESDPVRGPD GRMHGNKCAL CAEIFKQRFS EENSKTDQNL GKAEEKTKVK REIVKLCSQY QNQAKNGILF CTRENDPIRG PDGKMHGNLC SMCQAYFQAE NEEKKKAEAR ARNKRESGKA TSYAELCSEY RKLVRNGKLA CTRENDPIQG PDGKVHGNTC SMCEVFFQAE EEEKKKKEGK SRNKRQSKST ASFEELCSEY RKSRKNGRLF CTRENDPIQG PDGKMHGNTC SMCEAFFQQE ERARAKAKRE AAKEICSEFR DQVRNGTLIC TREHNPVRGP DGKMHGNKCA MCASVFKLEE EEKKNDKEEK GKVEAEKVKR EAVQELCSEY RHYVRNGRLP CTRENDPIEG LDGKIHGNTC SMCEAFFQQE AKEKERAEPR AKVKREAEKE TCDEFRRLLQ NGKLFCTREN DPVRGPDGKT HGNKCAMCKA VFQKENEERK RKEEEDQRNA AGHGSSGGGG GNTQDECAEY REQMKNGRLS CTRESDPVRD ADGKSYNNQC TMCKAKLERE AERKNEYSRS RSNGTGSESG KDTCDEFRSQ MKNGKLICTR ESDPVRGPDG KTHGNKCTMC KEKLEREAAE KKKKEDEDRS NTGERSNTGE RSNDKEDLCR EFRSMQRNGK LICTRENNPV RGPYGKMHIN KCAMCQSIFD REANERKKKD EEKSSSKPSN NAKDECSEFR NYIRNNELIC PRENDPVHGA DGKFYTNKCY MCRAVFLTEA LERAKLQEKP SHVRASQEED SPDSFSSLDS EMCKDYRVLP RIGYLCPKDL KPVCGDDGQT YNNPCMLCHE NLIRQTNTHI RSTGKCEESS TPGTTAASMP PSDE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.