Details for: LILRB4

Gene ID: 11006

Symbol: LILRB4

Ensembl ID: ENSG00000186818

Description: leukocyte immunoglobulin like receptor B4

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Apolipoprotein binding
    (GO:0034185)
  • Cell surface
    (GO:0009986)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasmic side of plasma membrane
    (GO:0009898)
  • Extracellular exosome
    (GO:0070062)
  • Fc receptor mediated inhibitory signaling pathway
    (GO:0002774)
  • Fibronectin binding
    (GO:0001968)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Interleukin-10-mediated signaling pathway
    (GO:0140105)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of cytotoxic t cell differentiation
    (GO:0045584)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of ip-10 production
    (GO:0071659)
  • Negative regulation of mapk cascade
    (GO:0043409)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of monocyte activation
    (GO:0150102)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of protein localization to nucleus
    (GO:1900181)
  • Negative regulation of protein tyrosine kinase activity
    (GO:0061099)
  • Negative regulation of signaling receptor activity
    (GO:2000272)
  • Negative regulation of t cell costimulation
    (GO:2000524)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Protein binding
    (GO:0005515)
  • Protein phosphatase binding
    (GO:0019903)
  • Receptor internalization
    (GO:0031623)
  • Signaling receptor inhibitor activity
    (GO:0030547)
  • Tolerance induction
    (GO:0002507)
  • Transmembrane receptor protein tyrosine kinase inhibitor activity
    (GO:0030293)

Other Information

Genular Protein ID: 3558230216

Symbol: LIRB4_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily B member 4

UniProtKB Accession Codes:

Q8NHJ6 A8MVL8 O15468 O75021 Q6FGQ9 Q8N1C7 Q8NHL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9278324

Title: Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor.

PubMed ID: 9278324

PubMed ID: 9548455

Title: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

PubMed ID: 9548455

PubMed ID: 10941837

Title: Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.

PubMed ID: 10941837

DOI: 10.1007/s002510000183

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9151699

Title: A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.

PubMed ID: 9151699

DOI: 10.1084/jem.185.10.1743

PubMed ID: 11875462

Title: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.

PubMed ID: 11875462

DOI: 10.1038/ni760

PubMed ID: 16493035

Title: Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells.

PubMed ID: 16493035

DOI: 10.4049/jimmunol.176.5.2790

PubMed ID: 19860908

Title: The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

PubMed ID: 19860908

DOI: 10.1186/1471-2172-10-56

PubMed ID: 19833736

Title: Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases.

PubMed ID: 19833736

DOI: 10.1074/jbc.m109.035683

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29263213

Title: ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.

PubMed ID: 29263213

DOI: 10.4049/jimmunol.1700553

PubMed ID: 30333625

Title: LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.

PubMed ID: 30333625

DOI: 10.1038/s41586-018-0615-z

PubMed ID: 34089617

Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.

PubMed ID: 34089617

DOI: 10.1093/intimm/dxab028

PubMed ID: 21454581

Title: Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.

PubMed ID: 21454581

DOI: 10.1074/jbc.m111.221028

Sequence Information:

  • Length: 448
  • Mass: 49356
  • Checksum: C18C21694F283FBB
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY 
AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYAQLHSFTL 
RQKATEPPPS QEGASPAEPS VYATLAIH

Genular Protein ID: 3203344391

Symbol: A0A0A0MSZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSZ8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 447
  • Mass: 49198
  • Checksum: 60368274B7C6F63D
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRSPH DEDPQAVTYA 
KVKHSRPRRE MASPPSPLSG EFLDTKDRQA EEDRQMDTEA AASEAPQDVT YARLHSFTLR 
QKATEPPPSQ EGASPAEPSV YATLAIH

Genular Protein ID: 3964452018

Symbol: A0A8Q3SHR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SHR1

Database IDs:

ARBA 1 CDD 1 CTD 1 EMBL 2 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 KEGG 1 MANE-Select 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 448
  • Mass: 49326
  • Checksum: 76D1E0B7AD3A1399
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY 
AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYARLHSFTL 
RQKATEPPPS QEGASPAEPS VYATLAIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.