Details for: LILRB4

Gene ID: 11006

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LILRB4

Ensembl ID: ENSG00000186818

Description: leukocyte immunoglobulin like receptor B4

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Apolipoprotein binding
    (GO:0034185)
  • Cell surface
    (GO:0009986)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasmic side of plasma membrane
    (GO:0009898)
  • Extracellular exosome
    (GO:0070062)
  • Fc receptor mediated inhibitory signaling pathway
    (GO:0002774)
  • Fibronectin binding
    (GO:0001968)
  • Immune response-regulating signaling pathway
    (GO:0002764)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Interleukin-10-mediated signaling pathway
    (GO:0140105)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of cytotoxic t cell differentiation
    (GO:0045584)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of ip-10 production
    (GO:0071659)
  • Negative regulation of mapk cascade
    (GO:0043409)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of monocyte activation
    (GO:0150102)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of protein localization to nucleus
    (GO:1900181)
  • Negative regulation of protein tyrosine kinase activity
    (GO:0061099)
  • Negative regulation of signaling receptor activity
    (GO:2000272)
  • Negative regulation of t cell costimulation
    (GO:2000524)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Protein binding
    (GO:0005515)
  • Protein phosphatase binding
    (GO:0019903)
  • Receptor internalization
    (GO:0031623)
  • Signaling receptor inhibitor activity
    (GO:0030547)
  • Tolerance induction
    (GO:0002507)
  • Transmembrane receptor protein tyrosine kinase inhibitor activity
    (GO:0030293)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmacytoid dendritic cell, human CL0001058
    CSI 47.94
    rCSI 33.47%
    PRS 86.16
  • elicited macrophage CL0000861
    CSI 36.54
    rCSI 33.55%
    PRS 89.72
  • plasmacytoid dendritic cell CL0000784
    CSI 30.04
    rCSI 30.42%
    PRS 93
  • alternatively activated macrophage CL0000890
    CSI 19.18
    rCSI 24.11%
    PRS 90.92
  • mononuclear phagocyte CL0000113
    CSI 13.08
    rCSI 28.79%
    PRS 86.17
  • microglial cell CL0000129
    CSI 12.75
    rCSI 51.3%
    PRS 83.76
  • non-classical monocyte CL0000875
    CSI 11.14
    rCSI 17.86%
    PRS 91.41
  • dendritic cell CL0000451
    CSI 11.04
    rCSI 13.6%
    PRS 85.26
  • Langerhans cell CL0000453
    CSI 9.49
    rCSI 14.5%
    PRS 92.02
  • lung interstitial macrophage CL4033043
    CSI 8.48
    rCSI 19.04%
    PRS 92.81
  • myeloid leukocyte CL0000766
    CSI 7.2
    rCSI 6.64%
    PRS 84.21
  • plasmablast CL0000980
    CSI 6.2
    rCSI 4.87%
    PRS 87.19
  • macrophage CL0000235
    CSI 6.01
    rCSI 10.93%
    PRS 87.98
  • monocyte CL0000576
    CSI 5.08
    rCSI 9.19%
    PRS 86.69
  • common dendritic progenitor CL0001029
    CSI 4.72
    rCSI 5.93%
    PRS 90.18
  • inflammatory macrophage CL0000863
    CSI 4.48
    rCSI 7.66%
    PRS 94.89
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 4.4
    rCSI 5.77%
    PRS 91.92
  • Kupffer cell CL0000091
    CSI 4.28
    rCSI 9.78%
    PRS 83.68
  • CD14-positive monocyte CL0001054
    CSI 3.9
    rCSI 4.86%
    PRS 90.7
  • conventional dendritic cell CL0000990
    CSI 3.6
    rCSI 3%
    PRS 81.21
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.16
    rCSI 3.81%
    PRS 89.53
  • colon macrophage CL0009038
    CSI 3.11
    rCSI 14.38%
    PRS 93.03
  • lung macrophage CL1001603
    CSI 2.3
    rCSI 5.13%
    PRS 89.27
  • mature NK T cell CL0000814
    CSI 2.22
    rCSI 2.84%
    PRS 90.74
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.05
    rCSI 1.58%
    PRS 85.92
  • intermediate monocyte CL0002393
    CSI 1.85
    rCSI 2.79%
    PRS 87.73
  • IgA plasma cell CL0000987
    CSI 1.79
    rCSI 1.84%
    PRS 88.78
  • dendritic cell, human CL0001056
    CSI 1.61
    rCSI 2.47%
    PRS 90.07
  • myeloid dendritic cell, human CL0001057
    CSI 1.37
    rCSI 7.71%
    PRS 93.53
  • myeloid dendritic cell CL0000782
    CSI 1.21
    rCSI 1.75%
    PRS 93.36
  • promonocyte CL0000559
    CSI 1.18
    rCSI 2.02%
    PRS 87.86
  • Hofbauer cell CL3000001
    CSI 1.04
    rCSI 1.96%
    PRS 89.79
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.51
    rCSI 3.08%
    PRS 92

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LILRB4](/details-gene/11006) (Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4), also known as ILT3, is a type I transmembrane protein that functions as an inhibitory receptor within the immune system. Structurally, it is a member of the leukocyte immunoglobulin-like receptor (LILR) family, characterized by extracellular Ig-like domains and cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs) [[Link](https://pubmed.ncbi.nlm.nih.gov/9278324/)]. **Overall**, expression data reveals that [LILRB4](/details-gene/11006) is a highly specific marker for myeloid lineage cells, particularly professional antigen-presenting cells (APCs). It is most significantly expressed in [plasmacytoid dendritic cells, human](/details-cell/CL0001058), [elicited macrophages](/details-cell/CL0000861), and other [mononuclear phagocytes](/details-cell/CL0000113), suggesting a primary role in modulating APC function to maintain immune tolerance and regulate inflammatory responses. Its function is crucial in preventing excessive immune activation, and its dysregulation is implicated in both cancer immune evasion and autoimmune diseases. ## Cellular Roles and Expression Landscape The expression profile of [LILRB4](/details-gene/11006) firmly establishes it as a key regulator within the myeloid compartment of the immune system. The **Overall** context analysis shows its highest significance in professional antigen-presenting cells. It is an exceptionally strong marker for [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 47.94) and [elicited macrophage](/details-cell/CL0000861) (CSI: 36.54), indicating a unique and defining role in these cell types. High significance is also observed across the broader mononuclear phagocyte system, including [alternatively activated macrophages](/details-cell/CL0000890), [microglial cells](/details-cell/CL0000129), [non-classical monocytes](/details-cell/CL0000875), and multiple subsets of [dendritic cells](/details-cell/CL0000451). This consistent high expression across various APCs underscores its general role in antigen presentation and immune response regulation [[Link](https://doi.org/10.1084/jem.185.10.1743)]. The gene's presence on these cells is critical for inducing T cell anergy and promoting the differentiation of regulatory T cells, thereby contributing to peripheral tolerance [[Link](https://doi.org/10.1038/ni760)], [[Link](https://doi.org/10.4049/jimmunol.176.5.2790)]. Notably, its restricted expression pattern suggests a specialized function, with low or absent expression in most non-myeloid lineages, which sharpens its utility as a marker for these specific immune populations. ## Pathways and Molecular Function [LILRB4](/details-gene/11006) functions predominantly as a negative regulator of immune signaling pathways. Its engagement leads to the phosphorylation of its cytoplasmic ITIM domains, which in turn recruit protein phosphatases like SHP-1. This initiates a cascade that dampens intracellular signaling. * **Immune Regulation:** Gene Ontology annotations highlight its extensive role in the negative regulation of immune responses. This includes suppressing T cell proliferation ([GO:0042130](https://www.ebi.ac.uk/QuickGO/term/GO:0042130)), T cell receptor signaling ([GO:0050860](https://www.ebi.ac.uk/QuickGO/term/GO:0050860)), and the activation of [monocytes](/details-cell/CL0000576) ([GO:0150102](https://www.ebi.ac.uk/QuickGO/term/GO:0150102)). This is consistent with its high expression in APCs, which directly interact with T cells. * **Cytokine Production:** [LILRB4](/details-gene/11006) signaling potently inhibits the production of numerous pro-inflammatory cytokines, such as interleukin-6 ([GO:0032715](https://www.ebi.ac.uk/QuickGO/term/GO:0032715)), interleukin-1 beta ([GO:0032691](https://www.ebi.ac.uk/QuickGO/term/GO:0032691)), and tumor necrosis factor ([GO:0032720](https://www.ebi.ac.uk/QuickGO/term/GO:0032720)). This function is central to its role in controlling inflammation and promoting a tolerogenic state. * **Molecular Interactions:** At the molecular level, [LILRB4](/details-gene/11006) exhibits "inhibitory MHC class I receptor activity" ([GO:0032396](https://www.ebi.ac.uk/QuickGO/term/GO:0032396)) and binds to various proteins, including apolipoproteins ([GO:0034185](https://www.ebi.ac.uk/QuickGO/term/GO:0034185)) and fibronectin ([GO:0001968](https://www.ebi.ac.uk/QuickGO/term/GO:0001968)). These interactions are critical for its function in diverse contexts, from leukemia immune evasion [[Link](https://doi.org/10.1038/s41586-018-0615-z)] to autoimmunity [[Link](https://doi.org/10.1093/intimm/dxab028)]. * **System-Level Pathways:** Its involvement is summarized in high-level Reactome pathways such as the "Adaptive immune system" ([R-HSA-1280218](https://reactome.org/content/detail/R-HSA-1280218)) and "Immunoregulatory interactions between a lymphoid and a non-lymphoid cell" ([R-HSA-198933](https://reactome.org/content/detail/R-HSA-198933)), placing it at the nexus of innate and adaptive immune control. ## Research Directions The specific expression of [LILRB4](/details-gene/11006) on myeloid cells and its potent inhibitory function make it a molecule of significant interest in pathology, particularly in oncology and autoimmunity. Research indicates that its expression on acute myeloid leukemia (AML) cells promotes tumor infiltration and suppresses T cell activity, facilitating immune escape [[Link](https://doi.org/10.1038/s41586-018-0615-z)]. Conversely, blocking its interaction with ligands like fibronectin has been shown to ameliorate autoimmune disease in mouse models [[Link](https://doi.org/10.1093/intimm/dxab028)]. Based on its established biology, several testable hypotheses can be proposed: 1. The exceptionally high expression of [LILRB4](/details-gene/11006) on [plasmacytoid dendritic cells](/details-cell/CL0000784) suggests it is a critical checkpoint for controlling type I interferon production. We hypothesize that engagement of [LILRB4](/details-gene/11006) on these cells by a ligand present in healthy tissue is essential for preventing inappropriate anti-viral responses to self-nucleic acids. 2. Given its role in suppressing APC function and its expression in tumor-associated macrophages (TAMs), we hypothesize that [LILRB4](/details-gene/11006) signaling is a key mechanism by which solid tumors polarize macrophages towards an immunosuppressive, M2-like phenotype, thereby hindering anti-tumor immunity. To test the second hypothesis regarding TAM polarization, a key experiment could involve the co-culture of tumor cell lines with primary human [monocytes](/details-cell/CL0000576) in the presence or absence of a [LILRB4](/details-gene/11006) blocking antibody. Following differentiation, the macrophage phenotype would be assessed by measuring the expression of M1/M2 markers (e.g., CD86, CD206) via flow cytometry and quantifying the secretion of immunosuppressive cytokines (e.g., IL-10, TGF-beta) and pro-inflammatory cytokines (e.g., TNF, IL-12) by ELISA. The functional consequence could be evaluated by subsequently using these polarized macrophages in a T cell suppression assay. Given its role as a surface-expressed inhibitory receptor, [LILRB4](/details-gene/11006) represents a highly attractive therapeutic target. Its function as an immune checkpoint, particularly in the context of myeloid-driven cancers like AML, positions it as a prime candidate for checkpoint blockade. A therapeutic strategy would involve **inhibition** using monoclonal antibodies to disrupt its suppressive signaling, thereby "releasing the brakes" on anti-tumor T cell and APC activity. This approach could restore immune surveillance and enhance the efficacy of other cancer therapies.

Genular Protein ID: 3558230216

Symbol: LIRB4_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily B member 4

UniProtKB Accession Codes:

Q8NHJ6 A8MVL8 O15468 O75021 Q6FGQ9 Q8N1C7 Q8NHL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9278324

Title: Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor.

PubMed ID: 9278324

PubMed ID: 9548455

Title: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

PubMed ID: 9548455

PubMed ID: 10941837

Title: Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.

PubMed ID: 10941837

DOI: 10.1007/s002510000183

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9151699

Title: A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.

PubMed ID: 9151699

DOI: 10.1084/jem.185.10.1743

PubMed ID: 11875462

Title: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.

PubMed ID: 11875462

DOI: 10.1038/ni760

PubMed ID: 16493035

Title: Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells.

PubMed ID: 16493035

DOI: 10.4049/jimmunol.176.5.2790

PubMed ID: 19860908

Title: The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

PubMed ID: 19860908

DOI: 10.1186/1471-2172-10-56

PubMed ID: 19833736

Title: Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases.

PubMed ID: 19833736

DOI: 10.1074/jbc.m109.035683

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29263213

Title: ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.

PubMed ID: 29263213

DOI: 10.4049/jimmunol.1700553

PubMed ID: 30333625

Title: LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.

PubMed ID: 30333625

DOI: 10.1038/s41586-018-0615-z

PubMed ID: 34089617

Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.

PubMed ID: 34089617

DOI: 10.1093/intimm/dxab028

PubMed ID: 21454581

Title: Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.

PubMed ID: 21454581

DOI: 10.1074/jbc.m111.221028

Sequence Information:

  • Length: 448
  • Mass: 49356
  • Checksum: C18C21694F283FBB
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY 
AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYAQLHSFTL 
RQKATEPPPS QEGASPAEPS VYATLAIH

Genular Protein ID: 3964452018

Symbol: A0A8Q3SHR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SHR1

Database IDs:

ARBA 1 CDD 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 448
  • Mass: 49326
  • Checksum: 76D1E0B7AD3A1399
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY 
AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYARLHSFTL 
RQKATEPPPS QEGASPAEPS VYATLAIH

Genular Protein ID: 3203344391

Symbol: A0A0A0MSZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSZ8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 447
  • Mass: 49198
  • Checksum: 60368274B7C6F63D
  • Sequence:
    • MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL 
DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA 
YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF 
PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED 
QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRSPH DEDPQAVTYA 
KVKHSRPRRE MASPPSPLSG EFLDTKDRQA EEDRQMDTEA AASEAPQDVT YARLHSFTLR 
QKATEPPPSQ EGASPAEPSV YATLAIH